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PubChem
Name: Progesterone
PubChem Compound ID: 10686837
Description: The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.
Molecular formula: C21H30O2
Molecular weight: 315.454 g/mol
DrugBank
Identification
Name: Progesterone
Name (isomeric): DB00396
Drug Type: small molecule
Description: The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.
Synonyms:
Corpus Luteum Hormone; Progesteronum; Progesterona [INN-Spanish]; Progesteronum [INN-Latin]
Brand: Syngestrets, Fologenon, Progestasert, Lutogyl, Progestosol, Piaponon, Lutidon, Progestogel, Prochieve, Proluton, Prolidon, Luteogan, Hormoflaveine, Membrettes, Lutromone, Prolutone, Prolets, Progekan, Progestron, Luteostab, Lutocyclin M, Gesterol, Corluvite, Thiuram E, Cyclogesterin, Progestol, Luteosan, Progeston, Lutocylol, Corlutina, Luteocrin Normale, Lingusorbs, Gestormone, Hormoluton, Syngesterone, Corporin, Lipo-Lutin, Delalutin, Lucorteum, Luteol, Pranone, Cycrin, Luteovis, Percutacrine Luteinique, Luteohormone, Lutocuclin M, Luteal Hormone, Prolutin, Protormone, Luteinique, Gestone, Projestaject, Progestone, Pregnenedione, Luteodyn, Gynlutin, Gesterol 50, Prometrium, Colprosterone, Agolutin, Gesterol 100, Progestin, Nalutron, Gynolutone, Thiuranide, Flavolutan, Lucorteum Sol, Curretab, Lutin, Syntolutan, Luteopur, Utrogestan, Bio-Luton, Percutacrine, Progesterol, Gestron, Lutoform, Methylpregnone, Lutren, Lutex, Lutociclina, Progestronol, Amen, Lutocylin, Glanducorpin, Crinone, Gynoluton, Cyclogest, Gestiron, Corlutin, Lutocyclin, Primolut
Brand name mixture:
Component E-C Implants(Estradiol Benzoate + Progesterone), Component E-S Implants with Tylan(Estradiol Benzoate + Progesterone + Tylosin Tartrate), Calf-Oid Implant(Estradiol Benzoate + Progesterone), Synovex C(Estradiol Benzoate + Progesterone), Synovex S(Estradiol Benzoate + Progesterone), Component E-S Implants(Estradiol Benzoate + Progestero...
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Category: Progestins, Contraceptives
CAS number: 57-83-0
Pharmacology
Indication: For progesterone supplementation or replacement as part of an Assisted Reproductive Technology (ART) treatment for infertile women with progesterone deficiency and for the treatment of secondary amenorrhea. Also used for the reduction of the incidence of endometrial hyperplasia and the attendant risk of endometrial carcinoma in postmenopausal women receiving estrogen replacement therapy, as well as treatment of abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology such as fibroids or uterine cancer.
Pharmacology:
Progesterone is a naturally occuring progestin or a synthetic form of the naturally occurring female sex hormone, progesterone. In a woman's normal menstrual cycle, an egg matures and is released from the ovaries (ovulation). The ovary then produces progesterone, preventing the release of further eggs and priming the lining of the womb for a possib...
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Mechanism of Action:
Progesterone shares the pharmacological actions of the progestins. Progesterone binds to the progesterone and estrogen receptors. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like Progesterone will slow the frequency of release of gonadotropin rele...
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Absorption: Progesterone absorption is prolonged with an absorption half-life of approximately 25-50 hours.
Protein binding: 96%-99%
Biotransformation: Progesterone is metabolized primarily by the liver largely to pregnanediols and pregnanolones.
Route of elimination: The glucuronide and sulfate conjugates of pregnanediol and pregnanolone are excreted in the urine and bile. Progesterone metabolites which are excreted in the bile may undergo enterohepatic recycling or may be excreted in the feces. Progesterone metabolites are excreted mainly by the kidneys.
Half Life: 34.8-55.13 hours
Clearance: 2510 +/- 135 L/day [cycling women]
Affected organisms: Humans and other mammals
Interactions
Food interaction:
Avoid alcohol.
Increase dietary intake of magnesium, folate, vitamin B6, B12, and/or consider taking a multivitamin.
Avoid excessive quantities of coffee or tea (Caffeine).
Take with food.
Take at the same time everyday.
Drug interaction:
TopotecanThe p-glycoprotein inhibitor, Progesterone, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.

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