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PubChem
Name: Aspirin
PubChem Compound ID: 21975
Description: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
Molecular formula: C19H18CaN2O9
Molecular weight: 458.432 g/mol
Synonyms:
CARBASPIRIN CALCIUM; 52080-78-1; Salicylic acid acetate calcium salt, compound with urea (1:1) complex; Carbasalate calcium; EINECS 227-273-0; Carbasalatum calcicum [INN-Latin]; D03385; Carbasalato calcico [INN-Spanish]; Carbaspirin calcium [USAN]; Carbaspirin calcium (USAN).
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DrugBank
Identification
Name: Aspirin
Name (isomeric): DB00945
Drug Type: small molecule
Description: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
Synonyms:
Acide acetylsalicylique (FRENCH); Acetilum acidulatum; Acido O-acetil-benzoico; o-Carboxyphenyl acetate; O-Acetylsalicylic acid; O-accetylsalicylic acid; Kyselina acetylsalicylova; Acetoxybenzoic acid; o-Acetoxybenzoic acid; 2-Acetoxybenzenecarboxylic acid.
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Brand: Bufferin, Delgesic, Levius, Rhodine, Caprin, Enterosarein, Acetonyl, Acetosal, Solprin, Tasprin, Persistin, Dolean pH 8, Solprin acid, Salacetin, Entrophen, 8-hour Bayer, Acetylin, Bialpirina, Endydol, Asteric, Enterosarine, Aspirine, Ecolen, Triaminicin, Helicon, Globentyl, Acetosalin, Saletin, Acetylsal, Adiro, Decaten, Triple-sal, Aspirdrops, Acetal, Coricidin, Idragin, Spira-Dine, Rhonal, Asatard, Benaspir, Vanquish, Salcetogen, Polopiryna, Extren, Crystar, Acenterine, Acetisal, Acisal, Bialpirinia, Empirin, Aceticyl, Aspec, Measurin, Yasta, Xaxa, Rheumintabletten, Acimetten, Pharmacin, Bayer Extra Strength Aspirin For Migraine Pain, Aspirin, Clariprin, Acetophen, Nu-seals aspirin, Acetol, Easprin, Entericin, Colfarit, Supac, St. Joseph Aspirin for Adults, Solfrin, Pirseal, Acesal, ECM, Aspalon, Premaspin, Claradin, Enterophen, Micristin, A.S.A. Empirin, Ecotrin, Globoid, Temperal, Aspergum, Nu-seals, Cemirit, Contrheuma retard, Novid, Ascoden-30, Asagran, Solpyron, Aspro, St. Joseph, Acylpyrin, Duramax, Bi-prin, Neuronika
Brand name mixture:
Aspirin Plus Stomach Guard Extra Strength(Acetylsalicylic Acid + Calcium Carbonate + Magnesium Carbonate + Magnesium Oxide), Aspirin with Stomach Guard(Acetylsalicylic Acid + Calcium Carbonate + Magnesium Carbonate + Magnesium Oxide), Extra Strength Aspirin Backache(Acetylsalicylic Acid + Methocarbamol), Aspirin Plus Stomach Guard Ext.Stgth.Capl...
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Category: Anticoagulants, Cyclooxygenase Inhibitors, Salicylates, Fibrinolytic Agents, Platelet Aggregation Inhibitors
CAS number: 50-78-2
Pharmacology
Indication: For use in the temporary relief of various forms of pain, inflammation associated with various conditions (including rheumatoid arthritis, juvenile rheumatoid arthritis, systemic lupus erythematosus, osteoarthritis, and ankylosing spondylitis), and is also used to reduce the risk of death and/or nonfatal myocardial infarction in patients with a previous infarction or unstable angina pectoris.
Pharmacology:
Acetylsalicylic acid is an analgesic, antipyretic, antirheumatic, and anti-inflammatory agent. Acetylsalicylic acid's mode of action as an antiinflammatory and antirheumatic agent may be due to inhibition of synthesis and release of prostaglandins. Acetylsalicylic acid appears to produce analgesia by virtue of both a peripheral and CNS effect. Peri...
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Mechanism of Action:
The analgesic, antipyretic, and anti-inflammatory effects of acetylsalicylic acid are due to actions by both the acetyl and the salicylate portions of the intact molecule as well as by the active salicylate metabolite. Acetylsalicylic acid directly and irreversibly inhibits the activity of both types of cyclooxygenase (COX-1 and COX-2) to decrease ...
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Absorption: Absorption is generally rapid and complete following oral administration but may vary according to specific salicylate used, dosage form, and other factors such as tablet dissolution rate and gastric or intraluminal pH.
Protein binding: High (99.5%) to albumin. Decreases as plasma salicylate concentration increases, with reduced plasma albumin concentration or renal dysfunction, and during pregnancy.
Biotransformation: Acetylsalicylic acid is rapidly hydrolyzed primarily in the liver to salicylic acid, which is conjugated with glycine (forming salicyluric acid) and glucuronic acid and excreted largely in the urine.
Half Life: The plasma half-life is approximately 15 minutes; that for salicylate lengthens as the dose increases: doses of 300 to 650 mg have a half-life of 3.1 to 3.2 hours; with doses of 1 gram, the half-life is increased to 5 hours and with 2 grams it is increased to about 9 hours.
Toxicity: Oral, mouse: LD50 = 250 mg/kg; Oral, rabbit: LD50 = 1010 mg/kg; Oral, rat: LD50 = 200 mg/kg. Effects of overdose include: tinnitus, abdominal pain, hypokalemia, hypoglycemia, pyrexia, hyperventilation, dysrhythmia, hypotension, hallucination, renal failure, confusion, seizure, coma, and death.
Affected organisms: Humans and other mammals
Interactions
Food interaction:
Take with food to reduce gastric irritation.
Avoid alcohol, alcohol appears to cause a 50 to 100% increases in ASA serum levels.
Take with a full glass of water.
Drug interaction:
MethazolamideAcetylsalicylic acid at high dose increases the effect of the carbonic anhydrase inhibitor, methazolamide.
Tiaprofenic acidIncreased risk of gastrointestinal bleeding.
MethotrexateAcetylsalicylic acid increases the effect and toxicity of methotrexate.
GlipizideAcetylsalicylic acid increases the effect of the sulfonylurea, glipizide.
ParamethasoneThe corticosteroid, paramethasone, may decrease the effect of the salicylate, acetylsalicylic acid.
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