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Name: anidulafungin
PubChem Compound ID: 166548
Molecular formula: C58H73N7O17
Molecular weight: 1140.24 g/mol
Echinocandin B, 1-((4R,5R)-4,5-dihydroxy-N2-((4-(pentyloxy)(1,1':4',1-terphenyl)-4-yl)carbonyl)-L-ornithine); Anidulafungin [USAN:INN]; V-Echinocandin; Anidulafungin; 166663-25-8; VER-002; LY-303366; Eraxis
Name: anidulafungin
Name (isomeric): DB00362
Drug Type: small molecule
Brand: Eraxis
Category: Antibiotics, Antifungal
CAS number: 166663-25-8
Indication: For use in the treatment of the following fungal infections: Candidemia and other forms of <i>Candida</i> infections (intra-abdominal abscess, and peritonitis), Aspergillus infections, and esophageal candidiasis. Also considered an alternative treatment for oropharyngeal canaidiasis.
Anidulafungin is a semi-synthetic lipopeptide synthesized from a fermentation product of Aspergillus nidulans. Anidulafungin is an echinocandin, a class of antifungal drugs that inhibits the synthesis of 1,3-β-D-glucan, an essential component of fungal cell walls. Anidulafungin is active in vitro against many Candida, as well as ...
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Mechanism of Action: Anidulafungin is a semi-synthetic echinocandin with antifungal activity. Anidulafungin inhibits glucan synthase, an enzyme present in fungal, but not mammalian cells. This results in inhibition of the formation of 1,3-β-D-glucan, an essential component of the fungal cell wall, ultimately leading to osmotic instability and cell death.
Protein binding: 84%
Biotransformation: Hepatic metabolism of anidulafungin has not been observed. Anidulafungin is not a clinically relevant substrate, inducer, or inhibitor of cytochrome P450 (CYP450) isoenzymes. Anidulafungin undergoes slow chemical degradation at physiologic temperature and pH to a ring-opened peptide that lacks antifungal activity.
Route of elimination: Less than 1% of the administered radioactive dose was excreted in the urine. Anidulafungin is not hepatically metabolized.
Half Life: 40-50 hours
Clearance: 1 L/h
Toxicity: During clinical trials a single 400 mg dose of anidulafungin was inadvertently administered as a loading dose. No clinical adverse events were reported. The maximum non-lethal dose of anidulafungin in rats was 50 mg/kg, a dose which is equivalent to 10 times the recommended daily dose for esophageal candidiasis (50mg/day).
Affected organisms: Aspergillis, Candida and other fungi