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QuickView for Zuclopenthixol (compound)


DrugBank
Identification
Name: Zuclopenthixol
Name (isomeric): DB01624
Drug Type: small molecule
Synonyms:
Clopenthixol; zuclopenthixol acetate; Zuclopenthixolum [latin]; zuclopenthixol dihydrochloride; zuclopenthixol decanoate; Zuclopentixol [spanish]
Brand: Clopixol, Acuphase
Category: Dopamine Antagonists, Antipsychotic Agents
CAS number: 53772-83-1
Pharmacology
Indication: For the management of the manifestations of schizophrenia.
Pharmacology: Zuclopenthixol is a thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors.
Mechanism of Action:
Zuclopenthixol is a typical antipsychotic neuroleptic drug of the thioxanthene group. It mainly acts by antagonism of D1 and D2 dopamine receptors. Zuclopenthixol also has high affinity for alpha1-adrenergic and 5-HT2 receptors. It has weaker histamine H1 receptor blocking activity, and even lower affinity for muscarinic cholinergic and alpha2-adre...
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Protein binding: Approximately 98%.
Biotransformation: The metabolism of zuclopenthixol is mainly by sulphoxidation, side chain N-dealkylation and glucuronic acid conjugation. The metabolites are devoid of pharmacological activity.
Half Life: 20 hours (range 12-28 hours) for the tablet form, 19 days for the depot form.
Toxicity: Although there have not been any cases of overdosage reported, the symptoms are likely to be somnolence, coma, extrapyramidal symptoms, convulsions, hypotension, shock, or hyper- or hypothermia.
Affected organisms: Humans and other mammals
Interactions
Drug interaction:
QuetiapineAdditive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
PimozideAdditive QTc-prolonging effects increases risk of cardiac arrhythmias. Concomitant therapy is contraindicated.
ProbucolAdditive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
ThiothixeneAdditive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
TrimipramineAdditive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
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Targets


Enzymes