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QuickView for Vitamin E (compound)


PubChem
Name: Vitamin E
PubChem Compound ID: 10741418
Description: A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.
Molecular formula: C29H50O2
Molecular weight: 432.699 g/mol
DrugBank
Identification
Name: Vitamin E
Name (isomeric): DB00163
Drug Type: small molecule
Description: A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.
Synonyms:
alpha-Tocopherol; Tocopherol
Brand: Gordo-Vite E, E-Vitamin succinate, Vitamin Plus E Softgells, E-Ferol, Daltose, Vitec, E-200 I.U. Softgels, Aquasol E, E-Complex-600, Amino-Opti-E
Category: Vitamins/minerals, Micronutrient, Antioxidants, Vitamins, Dietary supplement
CAS number: 59-02-9
Pharmacology
Indication: Vitamin E, known for its antioxidant activities, is protective against cardiovascular disease and some forms of cancer and has also demonstrated immune-enhancing effects. It may be of limited benefit in some with asthma and rheumatoid arthritis. It may be helpful in some neurological diseases including Alzheimer's, some eye disorders including cataracts, and diabetes and premenstrual syndrome. It may also help protect skin from ultraviolet irradiation although claims that it reverses skin aging, enhances male fertility and exercise performance are poorly supported. It may help relieve some muscle cramps.
Pharmacology:
Vitamin E has antioxidant activity. It may also have anti-atherogenic, antithrombotic, anticoagulant, neuroprotective, antiviral, immunomodulatory, cell membrane-stabilizing and antiproliferative actions. Vitamin E is a collective term used to describe eight separate forms, the best-known form being alpha-tocopherol. Vitamin E is a fat-soluble vita...
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Mechanism of Action:
Although all forms of Vitamin E exhibit antioxidant activity, it is known that the antioxidant activity of vitamin E is not sufficient to explain the vitamin's biological activity.
Vitamin E's anti-atherogenic activity involves the inhibition of the oxidation of LDL and the accumulation of oxLDL in the arterial wall. It also appears to reduce ...
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Absorption: 50 to 80% absorbed from gastrointestinal tract.
Protein binding: Bound to beta-lipoproteins in blood.
Biotransformation: Hepatic.
Affected organisms: Humans and other mammals
Interactions
Drug interaction:
AmprenavirIncreased serum levels of vitamin E
OrlistatOrlistat may impair the absorption of vitamin E, a fat soluble vitamin. Oral vitamin E should be administered 2 hours prior to or post orlistat administration.

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