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QuickView for Triprolidine (compound)


PubChem
Name: Triprolidine
PubChem Compound ID: 5282443
Description: Histamine H1 antagonist used in allergic rhinitis; ASTHMA; and URTICARIA. It is a component of COUGH and COLD medicines. It may cause drowsiness.
Molecular formula: C19H22N2
Molecular weight: 278.391 g/mol
Synonyms:
BIM-0025383.P001; trans-2-(3-(1-Pyrrolidinyl)-1-p-tolylpropenyl)pyridine; Tripolidina [INN-Spanish]; Triprolidinum [INN-Latin]; trans-1-(4-Methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene; (E)-2-(1-(4-Methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)pyridine; 550-70-9; CCRIS 7212; Pyridine, 2-(1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)-, (E)-; Triprolidin.
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DrugBank
Identification
Name: Triprolidine
Name (isomeric): DB00427
Drug Type: small molecule
Description: Histamine H1 antagonist used in allergic rhinitis; ASTHMA; and URTICARIA. It is a component of COUGH and COLD medicines. It may cause drowsiness.
Brand: Triprolidine HCL, Venen (TN), Triprolidine Hydrochloride, Myidyl, Actidil
Brand name mixture:
Coactifed Syrup(codeine phosphate + pseudoephedrine hydrochloride + triprolidine hydrochloride), Actifed DM Syrup(dextromethorphan hydrobromide + pseudoephedrine hydrochloride + triprolidine hydrochloride), Actifed Plus Caplets(acetaminophen + pseudoephedrine hydrochloride + triprolidine hydrochloride), Actifed Syrup(pseudoephedrine hydrochlorid...
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Category: Histamine H1 Antagonists, Anti-Allergic Agents
CAS number: 486-12-4
Pharmacology
Indication: For the symptomatic relief of seasonal or perennial allergic rhinitis or nonallergic rhinitis; allergic conjunctivitis; and mild, uncomplicated allergic skin manifestations of urticaria and angioedema. Also used in combination with other agents for the symptomatic relief of symptoms associated with the common cold.
Pharmacology:
In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once rel...
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Mechanism of Action: Triprolidine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
Absorption: Rapidly absorbed in the intestinal tract.
Half Life: 4 to 6 hours.
Toxicity: Symptoms of overdose include drowsiness, weakness, inco-ordination, difficulty with micturition, respiratory depression, hypotension, agitation, irritability, convulsions, hypertension, palpitation and tachycardia.
Affected organisms: Humans and other mammals
Interactions
Drug interaction:
SertralineThe CNS depressants, Triprolidine and Sertraline, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
NortriptylineTriprolidine and Nortriptyline, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Additive CNS depressant effects may also occur. Monitor for enhanced anticholinergic and CNS depressant effects.
PentobarbitalThe CNS depressants, Triprolidine and Pentobarbital, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
MethylscopolamineTriprolidine and Methylscopolamine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
TrazodoneThe CNS depressants, Triprolidine and Trazodone, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
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