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PubChem
Name: Ticarcillin
PubChem Compound ID: 104961
Description: An antibiotic derived from penicillin similar to CARBENICILLIN in action.
Molecular formula: C15H16N2O6S2
Molecular weight: 384.429 g/mol
Synonyms:
34787-01-4; Ticarcillin; C07139
DrugBank
Identification
Name: Ticarcillin
Name (isomeric): DB01607
Drug Type: small molecule
Description: An antibiotic derived from penicillin similar to CARBENICILLIN in action.
Synonyms:
Ticarcilina [inn-spanish]; Ticarcillin supplement; Ticarcillinum [inn-latin]; Ticarcilline [inn-french]
Brand name mixture: Timentin(Ticarcillin + Clavulanate)
Category: Anti-Bacterial Agents, Penicillins
CAS number: 34787-01-4
Pharmacology
Indication: For the treatment of bacterial infections.
Pharmacology: Ticarcillin is a semisynthetic antibiotic with a broad spectrum of bactericidal activity against many gram-positive and gram-negative aerobic and anaerobic bacteria. Ticarcillin is, however, susceptible to degradation by ß-lactamases, and therefore, the spectrum of activity does not normally include organisms which produce these enzymes.
Mechanism of Action: Ticarcillin's antibiotic properties arise from its ability to prevent cross-linking of peptidoglycan during cell wall synthesis when the bacteria tries to divide, causing death.
Protein binding: 45%
Half Life: 1.1 hours
Toxicity: As with other penicillins, neurotoxic reactions may arise when very high doses of ticarcillin are administered, especially in patients with impaired renal function.
Affected organisms: Enteric bacteria and other eubacteria
Interactions
Drug interaction:
Ethinyl EstradiolThis anti-infectious agent could decrease the effect of the oral contraceptive
Fusidic AcidFusidic acid may reduce the effect of Ticarcillin by inhibiting bacterial growth. Ticarcillin exerts its effects on actively growing bacteria. To achieve synergism, Ticarcillin should be administered at least 2 hours prior to using Fusidic acid.
StreptomycinTicarcillin may reduce the serum concentration of Streptomycin. Ticarcillin may inactivate Streptomycin in vitro and the two agents should not be administered simultaneously through the same IV line.
DemeclocyclineDemeclocycline may reduce the effect of Ticarcillin by inhibiting bacterial growth. Ticarcillin exerts its effects on actively growing bacteria. To achieve synergism, Ticarcillin should be administered at least 2 hours prior to using Demeclocycline.
AmikacinTicarcillin may reduce the serum concentration of Amikacin. Ticarcillin may inactivate Amikacin in vitro and the two agents should not be administered simultaneously through the same IV line.
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