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QuickView for Tetracycline (compound)


PubChem
Name: Tetracycline
PubChem Compound ID: 1548931
Description: A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.
Molecular formula: C22H25N2O8+
Molecular weight: 445.443 g/mol
Synonyms:
ZINC01530482
DrugBank
Identification
Name: Tetracycline
Name (isomeric): DB00759
Drug Type: small molecule
Description: A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.
Synonyms:
Tetracycline HCl; Anhydrotetracycline; TC
Brand: Deschlorobiomycin, Panmycin, Dumocyclin, Roviciclina, Lexacycline, Tetramed, Abramycin, Tetrex, Tetrachel, Criseociclina, Ambramycin, Tetra-CO, Tetraverine, Tetrafil, Tetradecin, Mericycline, Achromycin, Micycline, Ciclibion, Purocyclina, Cefracycline, Tetracycl, Topicycline, Enterocycline, Copharlan, Retet, SK-Tetracycline, Biocycline, Medocycline, Orlycycline, Bristaciclina, Tsiklomitsin, Bio-Tetra, Oletetrin, TAC, Amycin, Abricycline, Achromycin V, Cyclopar, Tetracycline II, Cytome, Polyotic, Resteclin, Vetacyclinum, Limecycline, Neocycline, Ambramicina, Polycycline, Robitet, Tetrabon, Tsiklomistsin, Solvocin, Democracin, Omegamycin, Liquamycin, Bristaciclin, Bristacycline, Sumycin, Hostacyclin, Veracin, Actisite, Agromicina, Tetracyn
Brand name mixture:
Helidac(Metronidazole + Bismuth subsalicylate + tetracycline hydrochloride), Neotetramed PWR(Neomycin sulfate + Tetracycline hydrochloride), Delta-Albaplex tablets(Novobiocin sodium + Prednisolone + Tetracycline hydrochloride), Neo-Chlor(Neomycin sulfate + Tetracycline hydrochloride), Neo Chlor PWR(Neomycin sulfate + Tetracycline hydrochloride),...
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Category: Protein Synthesis Inhibitors, Anti-Bacterial Agents, Antiprotozoals, Tetracyclines
CAS number: 60-54-8
Pharmacology
Indication: Used to treat bacterial infections such as Rocky Mountain spotted fever, typhus fever, tick fevers, Q fever, rickettsialpox and Brill-Zinsser disease. May be used to treat infections caused by Chlamydiae spp., B. burgdorferi (Lyme disease), and upper respiratory infections caused by typical (S. pneumoniae, H. influenzae, and M. catarrhalis) and atypical organisms (C. pneumoniae, M. pneumoniae, L. pneumophila). May also be used to treat acne. Tetracycline may be an alternative drug for people who are allergic to penicillin.
Pharmacology:
Tetracycline is a short-acting antibiotic that inhibits bacterial growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. It also binds to some extent to the 50S ribosomal subunit. This binding is reversible in nature. Additionally tetracycline may alter t...
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Mechanism of Action: Tetracycline passively diffuses through porin channels in the bacterial membrane and reversibly binds to the 30S ribosomal subunit, preventing binding of tRNA to the mRNA-ribosome complex, and thus interfering with protein synthesis.
Absorption: Bioavailability is less than 40% when administered via intramuscular injection, 100% intravenously, and 60-80% orally (fasting adults). Food and/or milk reduce GI absorption of oral preparations of tetracycline by 50% or more.
Protein binding: 20 - 67% protein bound
Biotransformation: Not metabolized
Route of elimination: They are concentrated by the liver in the bile and excreted in the urine and feces at high concentrations in a biologically active form.
Half Life: 6-12 hours
Toxicity: LD50=808mg/kg (orally in mice)
Affected organisms: Enteric bacteria and other eubacteria
Interactions
Food interaction:
Avoid milk, calcium containing dairy products, iron, antacids, or aluminium salts 2 hours before or 6 hours after using antacids while on this medication.
Take on empty stomach: 1 hour before or 2 hours after meals.
Take with a full glass of water.
Drug interaction:
Bismuth SubsalicylateFormation of non-absorbable complexes
TazobactamPossible antagonism of action
IsotretinoinIncreased risk of intracranial hypertension
DicumarolTetracycline may increase the anticoagulant effect of dicumarol.
AcenocoumarolTetracycline may increase the anticoagulant effect of acenocoumarol.
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