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QuickView for Talbutal (compound)


PubChem
Name: talbutal
PubChem Compound ID: 606974
Molecular formula: C13H20N2O3
Molecular weight: 252.31 g/mol
Synonyms:
Talbutal-permethylated
DrugBank
Identification
Name: talbutal
Name (isomeric): DB00306
Drug Type: small molecule
Synonyms:
5-Allyl-5-sec-butylbarbituric acid; sec-Butyl allyl barbituric acid
Brand: Profundol, Latusate, Lotusate
Category: Analgesics
CAS number: 115-44-6
Pharmacology
Indication: For use as a sedative and hypnotic.
Pharmacology: Talbutal is a short to intermediate-acting barbiturate. Barbiturates act as nonselective depressants of the central nervous system (CNS), capable of producing all levels of CNS mood alteration from excitation to mild sedation, hypnosis, and deep coma. In sufficiently high therapeutic doses, barbiturates induce anesthesia.
Mechanism of Action: Talbutal binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
Toxicity: Symptoms of acute barbiturate poisoning include drowsiness, confusion, coma, respiratory depression, hypotension, and shock.
Affected organisms: Humans and other mammals
Interactions
Drug interaction:
MedroxyprogesteroneThe enzyme inducer, talbutal, decreases the effect of the hormone agent, medroxyprogesterone.
TriamcinoloneThe barbiturate, talbutal, may decrease the effect of the corticosteroid, triamcinolone.
Ethinyl EstradiolThis product may cause a slight decrease of contraceptive effect
PrednisoneThe barbiturate, talbutal, may decrease the effect of the corticosteroid, prednisone.
FludrocortisoneThe barbiturate, talbutal, may decrease the effect of the corticosteroid, fludrocortisone.
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Targets