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PubChem
Name: Sotalol
PubChem Compound ID: 119259
Description: An adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.
Molecular formula: C12H20N2O3S
Molecular weight: 272.365 g/mol
Synonyms:
Methanesulfonamide, N-(4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)phenyl)-, (S)-; 30236-32-9; Dexsotalol
DrugBank
Identification
Name: Sotalol
Name (isomeric): DB00489
Drug Type: small molecule
Description: An adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.
Synonyms:
Sotalol HCL
Brand: Sorine, Betapace, Betapace AF
Category: Sympatholytics, Adrenergic beta-Antagonists, Anti-Arrhythmia Agents
CAS number: 3930-20-9
Pharmacology
Indication: For the maintenance of normal sinus rhythm [delay in time to recurrence of atrial fibrillation/atrial flutter (AFIB/AFL)] in patients with symptomatic AFIB/AFL who are currently in sinus rhythm. Also for the treatment of documented life-threatening ventricular arrhythmias.
Pharmacology:
Sotalol is an antiarrhythmic drug. It falls into the class of beta blockers (and class II antiarrhythmic agents) because of its primary action on the β-adrenergic receptors in the heart. In addition to its actions on the beta receptors in the heart, sotalol inhibits the inward potassium ion channels of the heart. In so doing, sotalol prolongs ...
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Mechanism of Action:
Sotalol has both beta-adrenoreceptor blocking (Vaughan Williams Class I) and cardiac action potential duration prolongation (Vaughan Williams Class I) antiarrhythmic properties. Sotalol is a racemic mixture of d- and l-sotalol. Both isomers have similar Class I antiarrhythmic effects, while the l-isomer is responsible for virtually all of the beta-...
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Absorption: In healthy subjects, the oral bioavailability of sotalol is 90-100%. Absorption is reduced by approximately 20% compared to fasting when administered with a standard meal.
Protein binding: Sotalol does not bind to plasma proteins.
Biotransformation: Sotalol is not metabolized.
Route of elimination: Excretion is predominantly via the kidney in the unchanged form. Sotalol is excreted in the milk of laboratory animals and has been reported to be present in human milk.
Half Life: Mean elimination half-life is 12 hours. Impaired renal function in geriatric patients can increase the terminal elimination half-life.
Toxicity: The most common signs to be expected are bradycardia, congestive heart failure, hypotension, bronchospasm and hypoglycemia. In cases of massive intentional overdosage (2-16 grams) of sotalol the following clinical findings were seen: hypotension, bradycardia, cardiac asystole, prolongation of QT interval, Torsade de Pointes, ventricular tachy-cardia, and premature ventricular complexes.
Affected organisms: Humans and other mammals
Interactions
Drug interaction:
IbuprofenRisk of inhibition of renal prostaglandins
GrepafloxacinIncreased risk of cardiotoxicity and arrhythmias
ErythromycinIncreased risk of cardiotoxicity and arrhythmias
MethyldopaPossible hypertensive crisis
TelithromycinAdditive QTc-prolongation may occur increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
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Targets