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QuickView for Secobarbital (compound)


PubChem
Name: Secobarbital
PubChem Compound ID: 30019
Description: A barbiturate that is used as a sedative. Secobarbital is reported to have no anti-anxiety activity.
Molecular formula: C12H18N2O3
Molecular weight: 238.283 g/mol
Synonyms:
S(-)-5-Allyl-5-(1-methylbutyl)-barbituric acid; 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(1-methylbutyl)-5-(2-propenyl)-, (S)- (9CI); S(-)-Secobarbital; 20224-45-7; BARBITURIC ACID, 5-ALLYL-5-(1-METHYLBUTYL)-, (S)-(-)-
DrugBank
Identification
Name: Secobarbital
Name (isomeric): DB00418
Drug Type: small molecule
Description: A barbiturate that is used as a sedative. Secobarbital is reported to have no anti-anxiety activity.
Synonyms:
Secobarbital Sodium; Sodium Secobarbital; Sodium quinalbarbitone; (+/-)-Secobarbital; Secobarbitale [DCIT]; Secobarbitalum [INN-Latin]
Brand: Meballymal, Quinalbarbitone, Seconal, Evrronal, Barbosec, Meballymalum, Trisomnin, Bipinal sodium, Quinalbarbital, Secobarbitone, Novosecobarb, Evronal Sodium, Sedutain, Somosal, Hyptran, Imesonal, Immenoctal, Bipanal, Seco 8, Sebar, Seotal, Evronal, Pramil, Hypotrol, Quinalspan, Meballymal sodium, Immenox, Quinalbarbitone sodium, Synate
Category: Adjuvants, Anesthesia, GABA Modulators, Hypnotics and Sedatives, Barbiturates, Adjuvants
CAS number: 76-73-3
Pharmacology
Indication: For the Short-term treatment of intractable insomnia for patients habituated to barbiturates
Pharmacology:
Secobarbital, a barbiturate, is used for the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful stimuli. Little analgesia is conferred by barbiturates; their use in the presence of pain may result in exc...
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Mechanism of Action: Secobarbital binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
Route of elimination: Barbiturates are metabolized primarily by the hepatic microsomal enzyme system, and the metabolic products are excreted in the urine and, less commonly, in the feces.
Toxicity: Symptoms of an overdose typically include sluggishness, incoordination, difficulty in thinking, slowness of speech, faulty judgment, drowsiness or coma, shallow breathing, staggering, and in severe cases coma and death.
Affected organisms: Humans and other mammals
Interactions
Drug interaction:
NifedipineThe barbiturate, secobarbital, decreases the effect of the calcium channel blocker, nifedipine.
TrimipramineThe barbiturate, Secobarbital, may increase the metabolism and clearance of Trimipramine. Monitor for changes in the therapeutics and adverse effects of Trimipramine if Secobarbital is initiated, discontinued or dose changed. Dose adjustments of Trimipramine may be required.
Ethinyl EstradiolThis product may cause a slight decrease of contraceptive effect
Folic AcidFolic acid decreases the effect of anticonvulsant, secobarbital.
TheophyllineThe barbiturate, secobarbital, decreases the effect of theophylline.
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