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QuickView for SNCA (gene)


Gene Symbol:
SNCA Homo sapiens Homo sapiens
Full name:
synuclein, alpha (non A4 component of amyloid precursor)
Synonyms:
synuclein alpha-140, synuclein, alpha (non A4 component of amyloid precursor), alpha-synuclein, alpha-synuclein, isoform NACP140, OTTHUMP00000161559, OTTHUMP00000161561, NACP, non A-beta component of AD amyloid, PARK1, PARK4, PD1, MGC110988
Genomic Location:
Chr 4: 90865728-90977156
Description:
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis ...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Gallus gallus Pan troglodytes Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 4
4q21





GO Molecular Function

fatty acid binding | endopeptidase inhibitor activity | cysteine-type endopeptidase inhibitor activity involved in apoptotic process | cation binding | alpha-tubulin binding | dynein binding | magnesium ion binding | carboxylic acid binding | ferrous iron binding | lipid binding | iron ion binding | enzyme inhibitor activity | binding | catalytic activity | Hsp70 protein binding | endopeptidase regulator activity | cytoskeletal protein binding | kinesin binding | tau protein binding | monocarboxylic acid binding | lipase inhibitor activity | identical protein binding | phospholipase D inhibitor activity | ion binding | copper ion binding | phosphoprotein binding | protein binding | zinc ion binding | peptidase regulator activity | histone binding | transition metal ion binding | calcium ion binding | phospholipase inhibitor activity | cysteine-type endopeptidase regulator activity involved in apoptotic process | tubulin binding | peptidase inhibitor activity | enzyme regulator activity | heat shock protein binding | metal ion binding | oxidoreductase activity | cysteine-type endopeptidase inhibitor activity

GO Biological Process

small molecule biosynthetic process | positive regulation of release of sequestered calcium ion into cytosol | negative regulation of G-protein coupled receptor protein signaling pathway | negative regulation of thrombin receptor signaling pathway | regulation of biological process | regulation of cysteine-type endopeptidase activity | endopeptidase inhibitor activity | regulation of microtubule polymerization or depolymerization | regulation of transmission of nerve impulse | extracellular structure organization | response to cytokine stimulus | response to interleukin-1 | positive regulation of cellular component organization | response to lipopolysaccharide | regulation of cellular localization | dopamine uptake involved in synaptic transmission | regulation of localization | catechol-containing compound metabolic process | regulation of biosynthetic process | positive regulation of cell communication | regulation of carbohydrate metabolic process | regulation of programmed cell death | cysteine-type endopeptidase inhibitor activity involved in apoptotic process | negative regulation of cysteine-type endopeptidase activity | establishment of localization | regulation of immune system process | negative regulation of neuron death | regulation of biological quality | negative regulation of cellular process | positive regulation of neurotransmitter secretion | response to metal ion | regulation of excitatory postsynaptic membrane potential | positive regulation of receptor recycling | cellular macromolecule metabolic process | defense response | response to drug | generation of precursor metabolites and energy | regulation of inositol phosphate biosynthetic process | cellular chemical homeostasis | positive regulation of phosphate metabolic process | regulation of protein modification process | regulation of organelle organization | cellular response to epinephrine stimulus | membrane organization | phospholipid metabolic process | dopamine transport | phenol-containing compound metabolic process | multicellular organismal signaling | regulation of response to stimulus | regulation of neuron death | positive regulation of neurological system process | positive regulation of cellular biosynthetic process | cellular process | regulation of catecholamine secretion | death | response to magnesium ion | localization | cellular homeostasis | negative regulation of cellular component organization | positive regulation of synaptic transmission | negative regulation of signaling | synaptic transmission | positive regulation of peptidyl-serine phosphorylation | regulation of neuronal synaptic plasticity | ATP synthesis coupled electron transport | anti-apoptosis | cellular respiration | negative regulation of microtubule polymerization or depolymerization | positive regulation of protein kinase activity | regulation of histone modification | negative regulation of apoptotic process | negative regulation of secretion | positive regulation of catalytic activity | cellular response to chemical stimulus | negative regulation of peptidyl-lysine acetylation | response to inorganic substance | negative regulation of cellular metabolic process | regulation of neurological system process | regulation of system process | negative regulation of neurotransmitter transport | positive regulation of cellular carbohydrate metabolic process | regulation of cellular process | cellular component organization or biogenesis | leukocyte activation | regulation of apoptotic process | regulation of metabolic process | regulation of protein complex assembly | positive regulation of cellular protein metabolic process | cellular response to organic nitrogen | cellular aromatic compound metabolic process | cellular component organization | cellular lipid metabolic process | calcium ion homeostasis | cellular response to metal ion | negative regulation of protein modification process | response to stimulus | enzyme inhibitor activity | negative regulation of catecholamine uptake involved in synaptic transmission | negative regulation of cell communication | oxoacid metabolic process | monocarboxylic acid metabolic process | response to chemical stimulus | transport | positive regulation of protein metabolic process | positive regulation of peptidase activity | regulation of leukocyte activation | response to stress | posttranscriptional regulation of gene expression | electron transport chain | positive regulation of cysteine-type endopeptidase activity | programmed cell death | protein destabilization | fibril organization | negative regulation of transporter activity | cellular response to inorganic substance | organic hydroxy compound transport | regulation of metal ion transport | regulation of cofactor metabolic process | regulation of neurotransmitter uptake | response to molecule of bacterial origin | extracellular matrix organization | negative regulation of transport | catecholamine biosynthetic process | response to endogenous stimulus | negative regulation of metabolic process | positive regulation of protein serine/threonine kinase activity | regulation of synaptic transmission | mitochondrion organization | response to iron ion | cell-cell signaling | synaptic transmission, dopaminergic | dopamine metabolic process | catalytic activity | metal ion homeostasis | regulation of membrane potential | regulation of neurotransmitter levels | negative regulation of neuron apoptotic process | regulation of long-term neuronal synaptic plasticity | apoptotic process | regulation of calcium ion transport into cytosol | regulation of signal transduction | regulation of protein stability | endopeptidase regulator activity | negative regulation of catalytic activity | regulation of peptidase activity | phosphorus metabolic process | positive regulation of multicellular organismal process | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | lipid metabolic process | cellular response to oxidative stress | regulation of phosphorylation | negative regulation of peptidase activity | cellular membrane organization | regulation of gene expression | regulation of postsynaptic membrane potential | positive regulation of secretion | organic substance transport | cellular response to stress | neurological system process | positive regulation of neurotransmitter transport | diol metabolic process | response to epinephrine stimulus | organophosphate metabolic process | regulation of protein polymerization | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | cellular ion homeostasis | adult locomotory behavior | regulation of macromolecule metabolic process | regulation of dopamine uptake involved in synaptic transmission | regulation of transferase activity | regulation of platelet-derived growth factor receptor signaling pathway | single-organism process | regulation of cysteine-type endopeptidase activity involved in apoptotic process | small molecule metabolic process | regulation of cellular carbohydrate metabolic process | lipase inhibitor activity | vesicle-mediated transport | dopamine biosynthetic process | response to oxidative stress | multi-organism process | synapse organization | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | regulation of synaptic transmission, dopaminergic | positive regulation of hydrolase activity | regulation of fatty acid metabolic process | phospholipase D inhibitor activity | catecholamine transport | regulation of release of sequestered calcium ion into cytosol | myeloid leukocyte activation | response to iron(II) ion | biological regulation | cellular ketone metabolic process | biosynthetic process | locomotory behavior | diol biosynthetic process | regulation of primary metabolic process | nitrogen compound transport | regulation of cellular protein metabolic process | regulation of amine transport | phosphorylation | negative regulation of histone modification | positive regulation of endopeptidase activity | negative regulation of norepinephrine uptake | cellular response to monoamine stimulus | regulation of phospholipase activity | positive regulation of macromolecule metabolic process | regulation of glutamate secretion | regulation of thrombin receptor signaling pathway | microglial cell activation | cation homeostasis | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | positive regulation of biological process | phosphate-containing compound metabolic process | negative regulation of response to stimulus | regulation of macrophage activation | response to bacterium | mitochondrial membrane organization | positive regulation of phosphorus metabolic process | negative regulation of neurotransmitter uptake | negative regulation of microtubule polymerization | cell communication | positive regulation of transferase activity | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of neuron apoptotic process | receptor internalization | negative regulation of serotonin uptake | synaptic vesicle endocytosis | response to catecholamine stimulus | mitochondrial ATP synthesis coupled electron transport | positive regulation of inositol phosphate biosynthetic process | regulation of catecholamine uptake involved in synaptic transmission | regulation of protein metabolic process | system process | positive regulation of biosynthetic process | homeostatic process | regulation of carbohydrate biosynthetic process | regulation of protein phosphorylation | regulation of locomotion | positive regulation of transport | regulation of dopamine secretion | regulation of microtubule-based process | carboxylic acid metabolic process | positive regulation of molecular function | negative regulation of exocytosis | negative regulation of monooxygenase activity | cellular component organization at cellular level | response to monoamine stimulus | negative regulation of protein polymerization | positive regulation of protein modification process | response to organic substance | neutral lipid metabolic process | positive regulation of transmission of nerve impulse | regulation of cellular biosynthetic process | catecholamine metabolic process | regulation of ion homeostasis | regulation of kinase activity | peptidase regulator activity | regulation of coenzyme metabolic process | regulation of exocytosis | positive regulation of homeostatic process | regulation of multicellular organismal process | metabolic process | neurotransmitter uptake | regulation of microtubule polymerization | primary metabolic process | activation of cysteine-type endopeptidase activity involved in apoptotic process | regulation of homeostatic process | regulation of peptidyl-lysine acetylation | oxidation-reduction process | negative regulation of programmed cell death | negative regulation of cytoskeleton organization | negative regulation of dopamine uptake involved in synaptic transmission | negative regulation of histone acetylation | regulation of vesicle-mediated transport | chemical homeostasis | endocytosis | regulation of secretion | behavior | membrane depolarization | oxidative phosphorylation | negative regulation of amine transport | macrophage activation | immune response | cellular response to stimulus | negative regulation of protein complex assembly | organic substance metabolic process | response to copper ion | regulation of hydrolase activity | neuron-neuron synaptic transmission | cell death | negative regulation of organelle organization | positive regulation of ion transport | regulation of norepinephrine uptake | negative regulation of cellular protein metabolic process | regulation of cell activation | cellular response to endogenous stimulus | regulation of lipase activity | positive regulation of kinase activity | ion homeostasis | regulation of phosphate metabolic process | catechol-containing compound biosynthetic process | regulation of chromosome organization | negative regulation of biological process | fatty acid metabolic process | regulation of serotonin uptake | regulation of acyl-CoA biosynthetic process | response to interferon-gamma | cell activation | regulation of monooxygenase activity | regulation of peptidyl-serine phosphorylation | adult behavior | negative regulation of protein metabolic process | positive regulation of carbohydrate metabolic process | regulation of cell communication | phospholipase inhibitor activity | cysteine-type endopeptidase regulator activity involved in apoptotic process | negative regulation of chromosome organization | negative regulation of molecular function | negative regulation of signal transduction | signaling | regulation of oxidoreductase activity | negative regulation of macromolecule metabolic process | regulation of endocytosis | single-organism behavior | regulation of molecular function | organic acid metabolic process | cellular component organization or biogenesis at cellular level | positive regulation of phosphorylation | peptidase inhibitor activity | enzyme regulator activity | regulation of endopeptidase activity | positive regulation of calcium ion transport into cytosol | response to biotic stimulus | regulation of cellular ketone metabolic process | regulation of ion transport | receptor-mediated endocytosis | regulation of G-protein coupled receptor protein signaling pathway | energy derivation by oxidation of organic compounds | organelle organization | regulation of calcium ion transport | monoamine transport | regulation of histone acetylation | positive regulation of cellular process | regulation of transport | catecholamine uptake involved in synaptic transmission | regulation of cellular component biogenesis | regulation of receptor recycling | innate immune response | neurotransmitter transport | negative regulation of oxidoreductase activity | receptor metabolic process | response to organic nitrogen | single-multicellular organism process | single organism signaling | transmission of nerve impulse | negative regulation of hydrolase activity | regulation of transporter activity | regulation of lipid metabolic process | regulation of neurotransmitter transport | positive regulation of metabolic process | regulation of synaptic plasticity | immune system process | cellular metabolic process | negative regulation of platelet-derived growth factor receptor signaling pathway | long-term synaptic potentiation | synaptic vesicle transport | cellular response to organic substance | regulation of cell death | cellular response to copper ion | oxidoreductase activity | cysteine-type endopeptidase inhibitor activity | negative regulation of cell death | divalent inorganic cation homeostasis | positive regulation of endocytosis | activation of cysteine-type endopeptidase activity | regulation of microtubule cytoskeleton organization | regulation of cellular component organization | positive regulation of calcium ion transport | regulation of cytoskeleton organization | response to other organism | positive regulation of signaling | cellular response to catecholamine stimulus | regulation of signaling | negative regulation of endopeptidase activity | regulation of neurotransmitter secretion | macromolecule metabolic process | multicellular organismal process | respiratory electron transport chain | regulation of phosphorus metabolic process

GO Cellular Component

secretory granule | fibril | intracellular membrane-bounded organelle | synapse | neuron projection | extracellular matrix | proteinaceous extracellular matrix | organelle membrane | cytoplasmic vesicle | platelet alpha granule membrane | extracellular matrix part | cell | intracellular non-membrane-bounded organelle | cell projection part | cytoplasm | intracellular organelle | actin cytoskeleton | platelet alpha granule | secretory granule membrane | inclusion body | cell projection | endomembrane system | plasma membrane | organelle part | intracellular organelle part | vesicle | perinuclear region of cytoplasm | mitochondrion | site of polarized growth | cell part | extracellular region | cell cortex | membrane-bounded organelle | nucleus | organelle | vesicle membrane | cell periphery | extracellular region part | cytoplasmic part | axon | cytoplasmic membrane-bounded vesicle | cytoplasmic vesicle part | growth cone | membrane-bounded vesicle | non-membrane-bounded organelle | cytosol | cytoskeleton | intracellular part | intracellular | cell junction | membrane | cytoplasmic vesicle membrane