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QuickView for SLC6A4 (gene)


Gene Symbol:
SLC6A4 Homo sapiens Homo sapiens
Full name:
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Synonyms:
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4, solute carrier family 6 member 4, sodium-dependent serotonin transporter, SERT, SERT1, Na+/Cl- dependent serotonin transporter, OTTHUMP00000163633, OCD1, HTT, hSERT, 5-HTT, 5-HTTLPR, 5-hydroxytryptamine transporter, 5HT transporter, 5HTT
Genomic Location:
Chr 17: 25549032-25586841
Description:
This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
CEBPB binding site geneset 2 FOXA2 binding site geneset 1 POU3F2 binding site geneset 1 ATF2 binding site geneset 2 TCF11 MAFG binding site geneset 1 NKX6-1 binding site geneset 1 Unknown transcription factor binding site geneset 57 Unknown transcription factor binding site geneset 58 Unknown transcription factor binding site geneset 60 E2F1 binding site geneset 2
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 17
17q11.2


Transcripts Names
NM_001045
Protein Names
P31645
B2R7Y7
Q5EE02



GO Molecular Function

actin binding | actin filament binding | GTPase binding | cation binding | neurotransmitter transporter activity | enzyme binding | syntaxin binding | transmembrane transporter activity | cocaine binding | myosin binding | serotonin transmembrane transporter activity | Ras GTPase binding | binding | symporter activity | cytoskeletal protein binding | cation transmembrane transporter activity | serotonin:sodium symporter activity | active transmembrane transporter activity | transporter activity | identical protein binding | ion transmembrane transporter activity | solute:cation symporter activity | substrate-specific transmembrane transporter activity | ion binding | organic cyclic compound binding | protein binding | protein homodimerization activity | metal ion transmembrane transporter activity | protein dimerization activity | nitric-oxide synthase binding | sodium ion transmembrane transporter activity | small GTPase binding | secondary active transmembrane transporter activity | Rab GTPase binding | substrate-specific transporter activity | monoamine transmembrane transporter activity | SNARE binding | neurotransmitter:sodium symporter activity | inorganic cation transmembrane transporter activity | monovalent inorganic cation transmembrane transporter activity | drug binding | syntaxin-1 binding | heterocyclic compound binding | solute:sodium symporter activity

GO Biological Process

response to extracellular stimulus | brain development | protein homooligomerization | regulation of biological process | negative regulation of multicellular organismal process | response to nutrient levels | serotonin uptake | regulation of transmission of nerve impulse | regulation of neurogenesis | response to cGMP | regulation of cell development | insemination | cellular response to external stimulus | establishment of localization | response to hormone stimulus | regulation of biological quality | negative regulation of cellular process | social behavior | cell differentiation | negative regulation of organ growth | nervous system development | cellular response to extracellular stimulus | response to drug | neurogenesis | generation of neurons | multicellular organismal signaling | cellular process | localization | negative regulation of signaling | metal ion transport | synaptic transmission | response to estradiol stimulus | neurotransmitter transporter activity | multicellular organismal reproductive process | response to hypoxia | macromolecular complex subunit organization | regulation of cell cycle | diencephalon development | cellular response to chemical stimulus | regulation of neurological system process | regulation of cell differentiation | regulation of system process | cellular response to retinoic acid | regulation of cellular process | cellular component organization or biogenesis | regulation of metabolic process | transmembrane transporter activity | negative regulation of synaptic transmission, dopaminergic | multi-multicellular organism process | cellular component organization | response to stimulus | negative regulation of cell communication | response to chemical stimulus | transport | protein complex assembly | regulation of blood vessel size | cellular response to vitamin A | negative regulation of neurological system process | response to stress | cellular response to vitamin | regulation of cell proliferation | circadian rhythm | regulation of anatomical structure size | serotonin transmembrane transporter activity | reproduction | rhythmic process | blood circulation | brain morphogenesis | response to endogenous stimulus | cellular component assembly | protein complex subunit organization | regulation of synaptic transmission | response to decreased oxygen levels | multi-organism behavior | cell-cell signaling | symporter activity | regulation of neurotransmitter levels | system development | cellular response to nutrient levels | response to oxygen levels | reproductive process | negative regulation of growth | multicellular organismal development | thalamus development | learning or memory | protein oligomerization | ion transmembrane transport | response to abiotic stimulus | positive regulation of cell cycle | regulation of neuron differentiation | regulation of gene expression | cellular component biogenesis | organic substance transport | neurological system process | copulation | sodium ion transport | cation transmembrane transporter activity | serotonin:sodium symporter activity | regulation of multicellular organismal development | monovalent inorganic cation transport | organ morphogenesis | regulation of macromolecule metabolic process | protein complex biogenesis | single-organism process | active transmembrane transporter activity | transporter activity | response to nutrient | multi-organism process | ion transmembrane transporter activity | regulation of synaptic transmission, dopaminergic | solute:cation symporter activity | cognition | biological regulation | nitrogen compound transport | vasoconstriction | response to vitamin A | positive regulation of macromolecule metabolic process | response to toxin | substrate-specific transmembrane transporter activity | positive regulation of biological process | negative regulation of developmental process | response to estrogen stimulus | cell communication | system process | serotonin transport | regulation of tube size | response to retinoic acid | sperm ejaculation | multicellular organism reproduction | macromolecular complex assembly | cellular response to nutrient | regulation of growth | response to organic substance | cellular developmental process | metal ion transmembrane transporter activity | anatomical structure development | regulation of multicellular organismal process | regulation of neural precursor cell proliferation | neurotransmitter uptake | circulatory system process | negative regulation of cerebellar granule cell precursor proliferation | behavior | cellular response to cGMP | cellular response to stimulus | single organism reproductive process | sodium ion transmembrane transport | mating | response to vitamin | organ development | forebrain development | negative regulation of neuron differentiation | sodium ion transmembrane transporter activity | negative regulation of biological process | secondary active transmembrane transporter activity | negative regulation of transmission of nerve impulse | memory | substrate-specific transporter activity | monoamine transmembrane transporter activity | neurotransmitter:sodium symporter activity | regulation of cell communication | transmembrane transport | signaling | inorganic cation transmembrane transporter activity | monovalent inorganic cation transmembrane transporter activity | single-organism behavior | anatomical structure morphogenesis | cation transport | regulation of organ growth | regulation of cerebellar granule cell precursor proliferation | regulation of nervous system development | regulation of developmental process | developmental process | response to external stimulus | multi-organism reproductive process | monoamine transport | positive regulation of cellular process | negative regulation of cell proliferation | negative regulation of neural precursor cell proliferation | neurotransmitter transport | single-multicellular organism process | single organism signaling | transmission of nerve impulse | negative regulation of synaptic transmission | central nervous system development | positive regulation of metabolic process | vascular process in circulatory system | ion transport | cellular response to organic substance | response to steroid hormone stimulus | negative regulation of cell differentiation | regulation of signaling | positive regulation of gene expression | solute:sodium symporter activity | multicellular organismal process

GO Cellular Component

integral to membrane | intracellular membrane-bounded organelle | plasma membrane part | endosomal part | organelle membrane | cell | intrinsic to membrane | cytoplasm | intracellular organelle | endosome membrane | endomembrane system | plasma membrane | organelle part | intracellular organelle part | membrane raft | membrane part | integral to plasma membrane | cell part | endosome | membrane-bounded organelle | organelle | cell periphery | cytoplasmic part | cytosol | intracellular part | intracellular | membrane | intrinsic to plasma membrane