Clear Search sequence regions
Bookmark Forward Export SNPs

QuickView for SLC12A1 (gene)


Gene Symbol:
SLC12A1 Homo sapiens Homo sapiens
Full name:
solute carrier family 12 (sodium/potassium/chloride transporters), member 1
Synonyms:
Na-K-2Cl cotransporter, NKCC2, NKCC2A variant A, MGC48843, kidney-specific Na-K-Cl symporter, BSC1, bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2, sodium potassium chloride cotransporter 2, solute carrier family 12 (sodium/potassium/chloride transporters), member 1, solute carrier family 12 member 1
Genomic Location:
Chr 15: 46285790-46383567
Description:
The sodium-potassium-chloride cotransporter isoform 2 is kidney-specific and is found on the apical membrane of the thick ascending limb of Henle's loop and the macula densa. It accounts for most of the NaCl resorption with the stoichiometry of 1Na:1K:2Cl and is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes r...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 15
15q15-q21.1


Transcripts Names
NM_000338
NM_001184832
Protein Names
B4DPF4
Q13621
E9PDW4
A8JYA2
Q8IUN5



GO Molecular Function

anion transmembrane transporter activity | anion:cation symporter activity | transmembrane transporter activity | inorganic anion transmembrane transporter activity | symporter activity | chloride transmembrane transporter activity | sodium:potassium:chloride symporter activity | cation transmembrane transporter activity | active transmembrane transporter activity | transporter activity | ion transmembrane transporter activity | solute:cation symporter activity | substrate-specific transmembrane transporter activity | secondary active transmembrane transporter activity | substrate-specific transporter activity | cation:chloride symporter activity

GO Biological Process

establishment of localization | anion transmembrane transporter activity | cellular process | localization | metal ion transport | anion transport | anion:cation symporter activity | transmembrane transporter activity | transport | chloride transport | inorganic anion transport | inorganic anion transmembrane transporter activity | symporter activity | chloride transmembrane transporter activity | sodium:potassium:chloride symporter activity | ion transmembrane transport | sodium ion transport | cation transmembrane transporter activity | monovalent inorganic cation transport | active transmembrane transporter activity | transporter activity | ion transmembrane transporter activity | potassium ion transport | solute:cation symporter activity | substrate-specific transmembrane transporter activity | secondary active transmembrane transporter activity | substrate-specific transporter activity | transmembrane transport | cation transport | cation:chloride symporter activity | ion transport

GO Cellular Component

integral to membrane | cell | intrinsic to membrane | plasma membrane | membrane part | cell part | cell periphery | membrane