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QuickView for SIRT1 (gene)


Gene Symbol:
SIRT1 Homo sapiens Homo sapiens
Full name:
sirtuin 1
Synonyms:
NAD-dependent deacetylase sirtuin-1, NAD-dependent protein deacetylase sirtuin-1, OTTHUMP00000019691, OTTHUMP00000060745, hSIR2, hSIRT1, regulatory protein SIR2 homolog 1, RP11-57G10.3, sir2-like 1, SIR2-like protein 1, SIR2alpha, SIR2L1, sirtuin 1, sirtuin type 1
Genomic Location:
Chr 10: 69314433-69348149
Description:
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and su...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
MAX binding site geneset 1 Unknown transcription factor binding site geneset 22 Unknown transcription factor binding site geneset 23 Unknown transcription factor binding site geneset 27 Unknown transcription factor binding site geneset 31 GTF3A binding site geneset 1 Unknown transcription factor binding site geneset 39 SREBF1 binding site geneset 1 ARNT binding site geneset 1 EGR3 binding site geneset 1
miRNA binding sites
(Source: TargetScan):
Predicted Gene Targets for miR-128 Predicted Gene Targets for miR-132 Predicted Gene Targets for miR-135 Predicted Gene Targets for miR-138 Predicted Gene Targets for miR-153 Predicted Gene Targets for miR-181 Predicted Gene Targets for miR-186 Predicted Gene Targets for miR-199 Predicted Gene Targets for miR-141 Predicted Gene Targets for miR-204
Cytogenetic Map:
chr 10
10q21.3


Transcripts Names
NM_012238
NM_001142498



GO Molecular Function

transcription factor binding transcription factor activity | histone deacetylase activity (H3-K9 specific) | kinase binding | cofactor binding | NAD+ ADP-ribosyltransferase activity | cation binding | protein kinase binding | enzyme binding | mitogen-activated protein kinase binding | nucleotide binding | coenzyme binding | hydrolase activity | protein deacetylase activity | binding | NAD+ binding | catalytic activity | protein domain specific binding | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | NAD-dependent protein deacetylase activity | histone deacetylase activity | p53 binding | bHLH transcription factor binding | transcription corepressor activity | identical protein binding | transferase activity, transferring glycosyl groups | ion binding | organic cyclic compound binding | NAD-dependent histone deacetylase activity | nucleoside phosphate binding | protein binding | transcription factor binding | NAD binding | transferase activity, transferring pentosyl groups | transferase activity | histone binding | deacetylase activity | protein binding transcription factor activity | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | HLH domain binding | transcription cofactor activity | metal ion binding | heterocyclic compound binding | protein C-terminus binding | small molecule binding | NAD-dependent histone deacetylase activity (H3-K9 specific)

GO Biological Process

positive regulation of immune response | RNA metabolic process | negative regulation of TOR signaling cascade | response to extracellular stimulus | positive regulation of cellular catabolic process | negative regulation of phosphorylation | response to radiation | regulation of biological process | cellular response to decreased oxygen levels | transcription factor binding transcription factor activity | positive regulation of macromolecule biosynthetic process | regulation of cysteine-type endopeptidase activity | regulation of intracellular protein transport | response to nutrient levels | positive regulation of cell aging | histone deacetylase activity (H3-K9 specific) | response to cytokine stimulus | RNA processing | developmental process involved in reproduction | regulation of cellular localization | intracellular signal transduction | regulation of cholesterol transport | positive regulation of response to nutrient levels | positive regulation of apoptotic process | proteolysis | regulation of localization | regulation of biosynthetic process | positive regulation of cell communication | gonad development | regulation of carbohydrate metabolic process | regulation of programmed cell death | female gonad development | peptidyl-amino acid modification | cellular response to external stimulus | regulation of cell aging | regulation of autophagy | nucleic acid metabolic process | response to hormone stimulus | regulation of immune system process | regulation of transforming growth factor beta receptor signaling pathway | regulation of biological quality | negative regulation of cellular process | negative regulation of kinase activity | positive regulation of developmental process | regulation of DNA metabolic process | cellular response to tumor necrosis factor | histone modification | cell differentiation | male gamete generation | cellular macromolecule metabolic process | negative regulation of fat cell differentiation | intrinsic apoptotic signaling pathway in response to DNA damage response | cellular response to extracellular stimulus | negative regulation of protein phosphorylation | cellular chemical homeostasis | histone deacetylation | glucose homeostasis | positive regulation of phosphate metabolic process | regulation of protein modification process | regulation of lipid transport | regulation of DNA repair | blood vessel morphogenesis | regulation of response to stimulus | positive regulation of cellular biosynthetic process | cellular process | regulation of gene expression, epigenetic | NAD+ ADP-ribosyltransferase activity | death | cellular homeostasis | proteolysis involved in cellular protein catabolic process | chromatin organization | establishment of chromatin silencing | regulation of DNA damage response, signal transduction by p53 class mediator | negative regulation of signaling | positive regulation of cholesterol efflux | reproductive system development | positive regulation of adaptive immune response | triglyceride metabolic process | multicellular organismal reproductive process | positive regulation of protein kinase activity | negative regulation of apoptotic process | negative regulation of lipid biosynthetic process | response to hypoxia | cellular response to starvation | negative regulation of phosphorus metabolic process | regulation of cell cycle | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | ribosome biogenesis | regulation of nucleobase-containing compound metabolic process | cellular response to chemical stimulus | negative regulation of peptidyl-lysine acetylation | response to inorganic substance | negative regulation of cellular metabolic process | response to peptide hormone stimulus | regulation of fat cell differentiation | regulation of cell differentiation | gamete generation | interspecies interaction between organisms | muscle structure development | intrinsic apoptotic signaling pathway | response to hydrogen peroxide | glycoprotein biosynthetic process | regulation of bile acid biosynthetic process | regulation of protein kinase B signaling cascade | regulation of immune response | regulation of cellular process | cellular component organization or biogenesis | regulation of apoptotic process | positive regulation of insulin receptor signaling pathway | gene silencing | regulation of metabolic process | catabolic process | regulation of endodeoxyribonuclease activity | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | regulation of MHC class II biosynthetic process | RNA biosynthetic process | regulation of response to stress | cellular aromatic compound metabolic process | positive regulation of catabolic process | cellular component organization | positive regulation of response to DNA damage stimulus | cellular lipid metabolic process | modification-dependent macromolecule catabolic process | positive regulation of chromatin silencing | development of primary sexual characteristics | negative regulation of transferase activity | negative regulation of protein modification process | response to stimulus | negative regulation of cell communication | cellular triglyceride homeostasis | ovulation | vasculature development | female gamete generation | regulation of transmembrane transport | maintenance of chromatin silencing | response to chemical stimulus | regulation of fatty acid biosynthetic process | positive regulation of immune system process | positive regulation of protein metabolic process | positive regulation of anti-apoptosis | positive regulation of peptidase activity | cellular response to hypoxia | hydrolase activity | response to stress | regulation of macromolecule biosynthetic process | regulation of intracellular steroid hormone receptor signaling pathway | negative regulation of protein kinase activity | posttranscriptional regulation of gene expression | regulation of cell proliferation | positive regulation of nucleobase-containing compound metabolic process | ovulation cycle | regulation of response to external stimulus | sterol homeostasis | positive regulation of cysteine-type endopeptidase activity | cholesterol homeostasis | response to starvation | regulation of cellular response to testosterone stimulus | ncRNA processing | programmed cell death | development of primary female sexual characteristics | protein destabilization | macromolecule biosynthetic process | regulation of unsaturated fatty acid biosynthetic process | reproduction | cellular protein catabolic process | cardiovascular system development | peptidyl-lysine acetylation | rhythmic process | regulation of gene silencing | cellular nitrogen compound metabolic process | proteasomal protein catabolic process | regulation of response to extracellular stimulus | regulation of macroautophagy | regulation of protein transport | carbohydrate derivative biosynthetic process | response to endogenous stimulus | negative regulation of metabolic process | positive regulation of protein serine/threonine kinase activity | protein modification process | protein deacetylase activity | pyrimidine dimer repair | macromolecule glycosylation | response to decreased oxygen levels | regulation of steroid biosynthetic process | cellular biosynthetic process | cellular catabolic process | ovulation from ovarian follicle | macromolecule modification | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | positive regulation of sterol transport | regulation of steroid metabolic process | histone H3 deacetylation | regulation of TOR signaling cascade | regulation of intracellular transport | catalytic activity | blood vessel development | DNA repair | negative regulation of NF-kappaB transcription factor activity | regulation of cellular response to stress | apoptotic process | regulation of macrophage apoptotic process | system development | cellular response to nutrient levels | response to oxygen levels | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | negative regulation of growth | regulation of protein stability | negative regulation of phosphate metabolic process | multicellular organismal development | negative regulation of catalytic activity | protein acetylation | NAD-dependent protein deacetylase activity | positive regulation of RNA metabolic process | cellular glucose homeostasis | regulation of peptidase activity | negative regulation of RNA metabolic process | single strand break repair | protein deacylation | response to DNA damage stimulus | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | lipid metabolic process | cellular response to oxidative stress | regulation of phosphorylation | response to abiotic stimulus | triglyceride mobilization | interaction with host | regulation of gene expression | DNA biosynthetic process | histone deacetylase activity | negative regulation of helicase activity | cellular component biogenesis | cellular response to stress | protein catabolic process | negative regulation of gene expression, epigenetic | regulation of protein import into nucleus, translocation | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | cellular response to radiation | pyrimidine dimer repair by nucleotide-excision repair | regulation of macromolecule metabolic process | regulation of protein localization to nucleus | regulation of transferase activity | cellular response to oxygen levels | regulation of nitrogen compound metabolic process | single-organism process | protein modification by small protein conjugation | regulation of cysteine-type endopeptidase activity involved in apoptotic process | negative regulation of nitrogen compound metabolic process | regulation of cellular carbohydrate metabolic process | negative regulation of sequence-specific DNA binding transcription factor activity | negative regulation of protein serine/threonine kinase activity | negative regulation of cAMP-dependent protein kinase activity | transcription corepressor activity | regulation of anti-apoptosis | regulation of transcription from RNA polymerase II promoter | regulation of smooth muscle cell apoptotic process | fat cell differentiation | response to oxidative stress | multi-organism process | positive regulation of hydrolase activity | cellular response to abiotic stimulus | regulation of fatty acid metabolic process | translation | transferase activity, transferring glycosyl groups | protein acylation | positive regulation of cholesterol transport | regulation of cAMP-dependent protein kinase activity | negative regulation of intracellular steroid hormone receptor signaling pathway | chromatin modification | cellular response to cytokine stimulus | biological regulation | biosynthetic process | negative regulation of protein kinase B signaling cascade | regulation of primary metabolic process | protein deacetylation | regulation of cellular protein metabolic process | angiogenesis | positive regulation of response to external stimulus | triglyceride homeostasis | positive regulation of endopeptidase activity | carbohydrate metabolic process | positive regulation of macromolecule metabolic process | positive regulation of leukocyte apoptotic process | rRNA metabolic process | regulation of cellular catabolic process | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | positive regulation of biological process | cellular component biogenesis at cellular level | positive regulation of cellular response to insulin stimulus | NAD-dependent histone deacetylase activity | ovulation cycle process | regulation of cellular macromolecule biosynthetic process | negative regulation of response to stimulus | negative regulation of developmental process | positive regulation of phosphorus metabolic process | negative regulation of nucleobase-containing compound metabolic process | regulation of muscle cell apoptotic process | regulation of response to nutrient levels | cell communication | positive regulation of transferase activity | regulation of cellular metabolic process | chromatin remodeling | regulation of protein kinase activity | regulation of protein metabolic process | positive regulation of signal transduction | positive regulation of biosynthetic process | regulation of androgen receptor signaling pathway | homeostatic process | positive regulation of cell proliferation | regulation of protein phosphorylation | glycerolipid metabolic process | regulation of RNA metabolic process | positive regulation of transport | viral reproduction | regulation of lipid biosynthetic process | negative regulation of cell growth | regulation of prostaglandin biosynthetic process | rRNA processing | apoptotic signaling pathway | cell aging | proteasomal ubiquitin-dependent protein catabolic process | regulation of mitotic cell cycle | regulation of catabolic process | positive regulation of molecular function | regulation of nucleocytoplasmic transport | regulation of nuclease activity | multicellular organism reproduction | cellular component organization at cellular level | protein metabolic process | regulation of establishment of protein localization | positive regulation of MHC class II biosynthetic process | negative regulation of transforming growth factor beta receptor signaling pathway | positive regulation of protein modification process | regulation of growth | response to organic substance | neutral lipid metabolic process | regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | protein ubiquitination | regulation of protein import into nucleus | cellular developmental process | regulation of cellular biosynthetic process | negative regulation of macromolecule biosynthetic process | regulation of kinase activity | DNA metabolic process | fatty acid homeostasis | negative regulation of DNA damage response, signal transduction by p53 class mediator | regulation of sequence-specific DNA binding transcription factor activity | regulation of intracellular protein kinase cascade | negative regulation of intracellular protein kinase cascade | cellular macromolecule catabolic process | response to insulin stimulus | anatomical structure development | protein ADP-ribosylation | regulation of glucose metabolic process | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | negative regulation of lipid metabolic process | metabolic process | nucleotide-excision repair | negative regulation of I-kappaB kinase/NF-kappaB cascade | primary metabolic process | positive regulation of cAMP-dependent protein kinase activity | regulation of adaptive immune response | regulation of peptidyl-lysine acetylation | regulation of chromatin silencing | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-dependent | negative regulation of programmed cell death | peptidyl-lysine modification | transferase activity, transferring pentosyl groups | cellular response to hydrogen peroxide | chemical homeostasis | positive regulation of cell death | macromolecule catabolic process | regulation of response to DNA damage stimulus | cellular response to stimulus | nucleobase-containing compound metabolic process | single organism reproductive process | cellular response to reactive oxygen species | organic substance metabolic process | regulation of hydrolase activity | cell death | negative regulation of biosynthetic process | negative regulation of gene expression | regulation of leukocyte apoptotic process | organ development | response to reactive oxygen species | regulation of insulin receptor signaling pathway | negative regulation of cellular protein metabolic process | gene expression | chromatin silencing at rDNA | positive regulation of programmed cell death | positive regulation of kinase activity | transferase activity | protein modification by small protein conjugation or removal | regulation of cellular response to insulin stimulus | cellular response to ionizing radiation | regulation of phosphate metabolic process | negative regulation of biological process | positive regulation of autophagy | transcription, DNA-dependent | negative regulation of cell aging | positive regulation of macroautophagy | ubiquitin-dependent protein catabolic process | viral reproductive process | anatomical structure formation involved in morphogenesis | negative regulation of protein metabolic process | positive regulation of macrophage apoptotic process | negative regulation of cellular response to testosterone stimulus | methylation-dependent chromatin silencing | negative regulation of androgen receptor signaling pathway | regulation of cell communication | regulation of peroxisome proliferator activated receptor signaling pathway | negative regulation of molecular function | negative regulation of signal transduction | negative regulation of cellular senescence | signaling | negative regulation of prostaglandin biosynthetic process | covalent chromatin modification | regulation of transcription, DNA-dependent | negative regulation of macromolecule metabolic process | regulation of molecular function | cellular component organization or biogenesis at cellular level | positive regulation of phosphorylation | cellular protein metabolic process | deacetylase activity | protein binding transcription factor activity | anatomical structure morphogenesis | regulation of endopeptidase activity | cellular macromolecule biosynthetic process | positive regulation of response to stimulus | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | reproductive structure development | regulation of cellular ketone metabolic process | regulation of developmental process | regulation of cholesterol efflux | positive regulation of DNA metabolic process | positive regulation of cellular senescence | developmental process | response to external stimulus | organelle organization | regulation of deoxyribonuclease activity | regulation of sterol transport | regulation of cell growth | multi-organism reproductive process | spermatogenesis | peptidyl-lysine deacetylation | cellular protein modification process | positive regulation of response to extracellular stimulus | negative regulation of cellular biosynthetic process | white fat cell differentiation | positive regulation of cellular process | negative regulation of transcription from RNA polymerase II promoter | carbohydrate derivative metabolic process | regulation of transport | positive regulation of transcription, DNA-dependent | virus-host interaction | DNA synthesis involved in DNA repair | ncRNA metabolic process | transcription cofactor activity | regulation of helicase activity | single-multicellular organism process | single organism signaling | positive regulation of transcription from RNA polymerase II promoter | heterocycle metabolic process | negative regulation of hydrolase activity | symbiosis, encompassing mutualism through parasitism | protein glycosylation | negative regulation of cellular macromolecule biosynthetic process | glycosylation | regulation of lipid metabolic process | negative regulation of response to DNA damage stimulus | positive regulation of metabolic process | chromosome organization | chromatin silencing | ribonucleoprotein complex biogenesis | regulation of execution phase of apoptosis | positive regulation of lipid transport | cellular metabolic process | female sex differentiation | response to tumor necrosis factor | cellular response to organic substance | regulation of protein localization | sex differentiation | regulation of cell death | modification-dependent protein catabolic process | signal transduction by p53 class mediator | DNA replication | negative regulation of cell death | acylglycerol metabolic process | circulatory system development | aging | carbohydrate homeostasis | negative regulation of fatty acid biosynthetic process | glycoprotein metabolic process | sexual reproduction | lipid homeostasis | regulation of I-kappaB kinase/NF-kappaB cascade | negative regulation of cell differentiation | regulation of cellular component organization | response to ionizing radiation | muscle organ development | positive regulation of signaling | negative regulation of fatty acid metabolic process | signal transduction | regulation of signaling | NAD-dependent histone deacetylase activity (H3-K9 specific) | positive regulation of gene expression | positive regulation of DNA repair | macromolecule metabolic process | regulation of cellular senescence | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

nuclear euchromatin | PcG protein complex | organelle inner membrane | chromosome | intracellular membrane-bounded organelle | rDNA heterochromatin | organelle membrane | nuclear membrane | cell | nuclear lumen | nuclear inner membrane | ESC/E(Z) complex | nucleolus | intracellular non-membrane-bounded organelle | cytoplasm | intracellular organelle | nuclear body | histone methyltransferase complex | euchromatin | nuclear chromosome part | macromolecular complex | PML body | methyltransferase complex | endomembrane system | nuclear part | nucleoplasm | nuclear envelope | chromatin | organelle part | intracellular organelle part | organelle lumen | nuclear chromosome | envelope | nucleoplasm part | organelle envelope | chromosomal part | cell part | membrane-bounded organelle | heterochromatin | nucleus | organelle | nuclear heterochromatin | membrane-enclosed lumen | intracellular organelle lumen | nuclear chromatin | chromatin remodeling complex | non-membrane-bounded organelle | chromatin silencing complex | intracellular part | intracellular | membrane | protein complex