Clear Search sequence regions
Bookmark Forward

QuickView for Rolitetracycline (compound)

Name: Rolitetracycline
PubChem Compound ID: 5282178
Description: A pyrrolidinylmethyl TETRACYCLINE.
Molecular formula: C54H74N8O25
Molecular weight: 1235.2 g/mol
26657-13-6; D01486; Rolitetracycline nitrate (JAN/USAN); Rolitetracycline nitrate; C12933
Name: Rolitetracycline
Name (isomeric): DB01301
Drug Type: small molecule
Description: A pyrrolidinylmethyl TETRACYCLINE.
Category: Anti-Bacterial Agents, Tetracyclines
CAS number: 751-97-3
Indication: Rolitetracycline is a broad-spectrum antibiotic used in cases needing high concentrations or when oral administration is impractical.
Mechanism of Action:
Rolitetracycline is a semisynthetic broad-spectrum tetracycline antibiotic used especially for parenteral administration in cases requiring high concentrations or when oral administration is impractical. Rolitetracycline passively diffuses through porin channels in the bacterial membrane and reversibly binds to the 30S ribosomal subunit, preventin...
show more »
Toxicity: Symptoms of overdose include anorexia, nausea, diarrhoea, glossitis, dysphagia, enterocolitis and inflammatory lesions (with monilial overgrowth) in the anogenital region, skin reactions such as maculopapular and erythematous rashes, exfoliative dermatitis, photosensitivity, hypersensitivity reactions such as urticaria, angioneurotic oedema, anaphylaxis, anaphyl-actoid purpura, pericarditis, and exacerbation of systemic lupus erythematosus, benign intracranial hypertension in adults disappearing on discontinuation of the medicine, haematologic abnormalities such as haemolytic anaemia, thrombocytopenia, neutropenia, and eosinophilia. LD50=262 mg/kg (I.P. in rat).
Drug interaction:
FlucloxacillinPossible antagonism of action
Penicillin VPossible antagonism of action
CloxacillinPossible antagonism of action
Ethinyl EstradiolThis anti-infectious agent could decrease the effect of the oral contraceptive
IsotretinoinIncreased risk of intracranial hypertension
show more »