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QuickView for Quinupristin (compound)


PubChem
Name: quinupristin
PubChem Compound ID: 11979364
Molecular formula: C53H67N9O10S
Molecular weight: 1022.22 g/mol
DrugBank
Identification
Name: quinupristin
Name (isomeric): DB01369
Drug Type: small molecule
Brand name mixture: Synercid(Dalfopristin + Quinupristin)
Category: Antibacterial Agents
CAS number: 120138-50-3
Pharmacology
Indication: For the treatment of bacterial infections (usually in combination with dalfopristin).
Pharmacology: Quinupristin is a streptogramin antibiotic, derived from pristinamycin I. By inhibiting the bacterial ribosomal subunits, protein synthesis is inhibited thus leading to eventual bacterial cell death or stasis.
Mechanism of Action:
Quinupristin inhibits the late phase of protein synthesis in the bacterial ribosome. Dalfopristin binds to the 23S portion of the 50S ribosomal subunit, and changes the conformation it, enhancing the binding of quinupristin by a factor of about 100. In addition, it inhibits peptidyl transferase. Quinupristin binds to a nearby site on the 50S riboso...
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Protein binding: Moderate.
Biotransformation: Quinupristin is converted to two conjugated active major metabolites, one with glutathione and one with cysteine.
Half Life: 3.1 hours
Affected organisms: Enteric bacteria and other eubacteria
Interactions
Drug interaction:
TamoxifenThis combination presents an increased risk of toxicity
CerivastatinThis combination presents an increased risk of toxicity
NevirapineThis combination presents an increased risk of toxicity
MoexiprilThis combination presents an increased risk of toxicity
FosphenytoinThis combination presents an increased risk of toxicity
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Targets