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QuickView for Protriptyline (compound)


PubChem
Name: Protriptyline
PubChem Compound ID: 14667
Description: Tricyclic antidepressant similar in action and side effects to IMIPRAMINE. It may produce excitation.
Molecular formula: C19H22ClN
Molecular weight: 299.837 g/mol
Synonyms:
438-60-8; MK-240; Vivactil; 5H-Dibenzo(a,d)cycloheptene-5-propanamine, N-methyl-, hydrochloride; EINECS 214-956-3; Triptil Hydrochloride; 5H-DIBENZO(a,d)CYCLOHEPTEN-5-PROPYLAMINE, N-METHYL-, HYDROCHLORIDE; 5H-Dibenzo(a,d)cycloheptene-5-propylamine, N-methyl-, hydrochloride (8CI); Protriptyline hydrochloride; Triptyl.
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DrugBank
Identification
Name: Protriptyline
Name (isomeric): DB00344
Drug Type: small molecule
Description: Tricyclic antidepressant similar in action and side effects to IMIPRAMINE. It may produce excitation.
Synonyms:
Protryptyline
Brand: Impril, Vivactil, Norpramin, Aventyl, Novotriptyn, Apo-Trimip, Anafranil, Triptil, Amimetilina, Rhotrimine, Asendin, Apo-Imipramine, Novo-Doxepin, Levate, Apo-Amitriptyline, Novo-Tripramine, Triadapin 5, Surmontil, Sinequan, Tofranil, Pertofrane, Novopramine
Category: Norepinephrine-Reuptake Inhibitors, Adrenergic Uptake Inhibitors, Antidepressive Agents, Antidepressive Agents, Tricyclic
CAS number: 438-60-8
Pharmacology
Indication: For the treatment of depression.
Pharmacology:
Protriptyline is a tricyclic antidepressant. It was thought that tricyclic antidepressants work by inhibiting the reuptake of the neurotransmitters norepinephrine and serotonin by nerve cells. However, this response occurs immediately, yet mood does not lift for approximately two weeks. It is now thought that changes occur in receptor sensitivity i...
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Mechanism of Action: Protriptyline acts by decreasing the reuptake of norepinephrine and serotonin (5-HT).
Route of elimination: Cumulative urinary excretion during 16 days accounted for approximately 50% of the drug. The fecal route of excretion did not seem to be important.
Toxicity: Side effects include anxiety, blood disorders, confusion, decreased libido, dizziness, flushing, headache, impotence, insomnia, low blood pressure, nightmares, rapid or irregular heartbeat, rash, seizures, sensitivity to sunlight, stomach and intestinal discomfort, sedation, hypotension, blurred vision, dry mouth, constipation, urinary retention, postural hypotension, tachycardia, hypertension, ECG changes, heart failure, impaired memory and delirium, and precipitation of hypomanic or manic episodes in bipolar depression. Withdrawal symptoms include gastrointestinal disturbances, anxiety, and insomnia.
Affected organisms: Humans and other mammals
Interactions
Drug interaction:
TriprolidineTriprolidine and Protriptyline, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Additive CNS depressant effects may also occur. Monitor for enhanced anticholinergic and CNS depressant effects.
GrepafloxacinIncreased risk of cardiotoxicity and arrhythmias
TrospiumTrospium and Protriptyline, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
TerbutalineThe tricyclic antidepressant, protriptyline, increases the sympathomimetic effect of terbutaline.
ClonidineThe tricyclic antidepressant, protriptyline, decreases the effect of clonidine.
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