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QuickView for Primidone (compound)


PubChem
Name: Primidone
PubChem Compound ID: 4909
Description: An antiepileptic agent related to the barbiturates; it is partly metabolized to PHENOBARBITAL in the body and owes some of its actions to this metabolite. Adverse effects are reported to be more frequent than with PHENOBARBITAL. (From Martindale, The Extra Pharmacopoeia, 30th ed, p309)
Molecular formula: C12H14N2O2
Molecular weight: 218.252 g/mol
Synonyms:
DivK1c_000324; Mysoline; Sertan; Mysoline (TN); Lopac-P-7295; D00474; Hexadiona; Liskantin; Spectrum4_000485; Prilepsin.
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DrugBank
Identification
Name: Primidone
Name (isomeric): DB00794
Drug Type: small molecule
Description: An antiepileptic agent related to the barbiturates; it is partly metabolized to PHENOBARBITAL in the body and owes some of its actions to this metabolite. Adverse effects are reported to be more frequent than with PHENOBARBITAL. (From Martindale, The Extra Pharmacopoeia, 30th ed, p309)
Brand: Misodine, Mizodin, Desoxyphenobarbitone, Pyrimidone Medi-Pets, Myidone, Primoline, Resimatil, Midone, Majsolin, Prysoline, Lepimidin, Mysoline, Pms Primidone, Mizolin, Hexamidine, Cyral, Mylepsin, Primacone, Mysedon, Primidone Methanol Solution, Primidon, Liskantin, Primaclone, Lepsiral, Primakton, Milepsin, Medi-Pets, Pyrimidone "Medi-Pets", Apo-Primidone, Mylepsinum, Hexadiona, Misolyne, Sertan, Neurosyn, Prilepsin, Primacione
Category: Barbiturates, Anticonvulsants
CAS number: 125-33-7
Pharmacology
Indication: For the treatment of epilepsy
Pharmacology:
Primidone is a barbiturate with anticonvulsant properties. Primidone, either alone or used concomitantly with other anticonvulsants, is indicated in the control of grand mal, psychomotor, and focal epileptic seizures. It may control grand mal seizures refractory to other anticonvulsant therapy. Primidone raises electro- or chemoshock seizure thresh...
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Mechanism of Action: Primidone is a GABA receptor agonist. The mechanism of Primidone's antiepileptic action is not known.
Absorption: 90 to 100%
Protein binding: 70%
Biotransformation: Hepatic
Half Life: 3-23 hours
Toxicity: Symptoms of an overdose typically include sluggishness, incoordination, difficulty in thinking, slowness of speech, faulty judgment, drowsiness or coma, shallow breathing, staggering, and in severe cases coma and death.
Affected organisms: Humans and other mammals
Interactions
Food interaction:
Avoid alcohol.
Avoid high doses of caffeine.
Take with food to reduce gastric irritation.
Drug interaction:
HydrocortisoneThe barbiturate, primidone, may decrease the effect of the corticosteroid, hydrocortisone.
QuinidineThe anticonvulsant, primidone, decreases the effect of quinidine.
VoriconazoleThe barbiturate, primidone, decreases the effect of voriconazole.
AminophyllineThe barbiturate, primidone, decreases the effect of aminophylline.
Ethinyl EstradiolThis product may cause a slight decrease of contraceptive effect
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