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QuickView for Pivampicillin (compound)


PubChem
Name: Pivampicillin
PubChem Compound ID: 126935
Description: Pivalate ester analog of AMPICILLIN.
Molecular formula: C22H29N3O6S
Molecular weight: 463.548 g/mol
DrugBank
Identification
Name: Pivampicillin
Name (isomeric): DB01604
Drug Type: small molecule
Description: Pivalate ester analog of AMPICILLIN.
Synonyms:
Pivampicilline [inn-french]; Pivaloylampicillin; Pivampicillinum [inn-latin]; Pivampicilina [inn-spanish]; Ampicillin pivaloyloxymethyl ester; Pivaloyloxymethyl ampicillinate
Brand: Pondocillin
Category: Anti-Bacterial Agents, Penicillins
CAS number: 33817-20-8
Pharmacology
Indication: or the treatment of respiratory tract infections (including acute bronchitis, acute exacerbations of chronic bronchitis and pneumonia); ear, nose and throat infections; gynecological infections; urinary tract infections (including acute uncomplicated gonococcal urethritis) when caused by non penicillinase-producing susceptible strains of the following organisms: gram-positive organisms, e.g., streptococci, pneumococci and staphylococci; gram-negative organisms, e.g., H. influenzae, N. gonorrhoeae, E. coli, P. mirabilis.
Pharmacology:
Pivampicillin is the pivaloyloxymethyl ester of (the semi-synthetic penicillin) ampicillin. It is an inactive pro-drug, which is converted during its absorption from the gastrointestinal tract to the microbiologically active ampicillin, together with formaldehyde and pivalic acid, by non-specific esterases present in most body tissues. Amounts in e...
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Mechanism of Action: Ampicillin (the active metabolite of pivampicillin) has a bactericidal action resulting from inhibition of cell wall mucopeptide biosynthesis.
Absorption: Absorbed following oral administration.
Half Life: Approximately 1 hour.
Affected organisms: Enteric bacteria and other eubacteria
Interactions
Food interaction:
Take without regard to meals.
Drug interaction:
OxytetracyclinePossible antagonism of action
Ethinyl EstradiolThis anti-infectious agent could decrease the effect of the oral contraceptive
MethacyclinePossible antagonism of action
DoxycyclinePossible antagonism of action
DemeclocyclinePossible antagonism of action
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Targets