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QuickView for PTEN (gene)


Gene Symbol:
PTEN Homo sapiens Homo sapiens
Full name:
phosphatase and tensin homolog
Synonyms:
BZS, 10q23del, DEC, GLM2, PTEN1, TEP1, OTTHUMP00000020032, MMAC1, MMAC1 phosphatase and tensin homolog deleted on chromosome 10, MHAM, mutated in multiple advanced cancers 1, MGC11227, phosphatase and tensin homolog, phosphatase and tensin-like protein, phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Genomic Location:
Chr 10: 89613175-89718512
Description:
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Danio rerio Canis lupus familiaris Gallus gallus Pan troglodytes Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Unknown transcription factor binding site geneset 3 POU2F1 binding site geneset 1 POU2F1 binding site geneset 4 POU2F1 binding site geneset 5 POU2F1 binding site geneset 7 Unknown transcription factor binding site geneset 37 GFI1 binding site geneset 1 POU2F1 binding site geneset 9 POU3F2 binding site geneset 3 CEBPD binding site geneset 1
miRNA binding sites
(Source: TargetScan):
miRNA binding sites
(Source: miRecords):
Cytogenetic Map:
chr 10
10q23.3


Transcripts Names
NM_000314
Protein Names
Q6ICT7
F6KD01
P60484
B2R904



GO Molecular Function

protein serine/threonine phosphatase activity | phosphatidylinositol bisphosphate phosphatase activity | kinase binding | inositol tetrakisphosphate phosphatase activity | cation binding | protein kinase binding | magnesium ion binding | enzyme binding | protein complex binding | lipid binding | inositol phosphate phosphatase activity | phosphatase activity | anaphase-promoting complex binding | protein tyrosine/serine/threonine phosphatase activity | phosphatidylinositol trisphosphate phosphatase activity | hydrolase activity | phosphatidylinositol monophosphate phosphatase activity | binding | protein tyrosine phosphatase activity | catalytic activity | protein domain specific binding | phosphoprotein phosphatase activity | inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity | hydrolase activity, acting on ester bonds | phosphatidylinositol phosphate phosphatase activity | ion binding | phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity | protein binding | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity | phosphatidylinositol-3-phosphatase activity | phosphoric ester hydrolase activity | PDZ domain binding | metal ion binding

GO Biological Process

positive regulation of immune response | protein serine/threonine phosphatase activity | phosphatidylinositol bisphosphate phosphatase activity | positive regulation of cellular catabolic process | negative regulation of phosphorylation | brain development | negative regulation of excitatory postsynaptic membrane potential | negative regulation of phosphatidylinositol 3-kinase cascade | cell morphogenesis | regulation of biological process | regulation of cell cycle process | negative regulation of multicellular organismal process | dendritic spine development | protein dephosphorylation | regulation of transmission of nerve impulse | positive regulation of cellular component organization | cell motility | regulation of cell morphogenesis | regulation of neurogenesis | neuron projection morphogenesis | immune response-regulating signaling pathway | developmental process involved in reproduction | organelle fission | muscle tissue development | intracellular signal transduction | positive regulation of apoptotic process | regulation of cell development | protein stabilization | regulation of localization | prostate gland growth | regulation of biosynthetic process | positive regulation of sequence-specific DNA binding transcription factor activity | positive regulation of cell communication | regulation of programmed cell death | regulation of cell aging | hippocampus development | phosphatidylinositol metabolic process | forebrain morphogenesis | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | regulation of biological quality | negative regulation of cellular process | negative regulation of kinase activity | regulation of ligase activity | negative regulation of response to external stimulus | social behavior | cell differentiation | inositol tetrakisphosphate phosphatase activity | immune response-activating cell surface receptor signaling pathway | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | regulation of excitatory postsynaptic membrane potential | T cell receptor signaling pathway | cell cycle phase | cellular macromolecule metabolic process | negative regulation of cell-matrix adhesion | negative regulation of organ growth | nervous system development | positive regulation of protein catabolic process | organophosphate catabolic process | negative regulation of protein phosphorylation | cellular chemical homeostasis | cell part morphogenesis | regulation of cell-substrate junction assembly | positive regulation of ligase activity | regulation of G1/S transition of mitotic cell cycle | neurogenesis | regulation of protein modification process | prepulse inhibition | regulation of organelle organization | generation of neurons | membrane organization | phospholipid metabolic process | blood vessel morphogenesis | multicellular organismal signaling | regulation of response to stimulus | positive regulation of neurological system process | cellular process | negative regulation of axonogenesis | death | regulation of cell motility | central nervous system neuron axonogenesis | regulation of dendritic spine morphogenesis | localization | cellular homeostasis | axon ensheathment | negative regulation of cellular component organization | cell projection morphogenesis | positive regulation of synaptic transmission | regulation of ubiquitin-protein ligase activity | negative regulation of signaling | developmental growth | synaptic transmission | neuron development | negative regulation of G1/S transition of mitotic cell cycle | central nervous system neuron differentiation | reproductive system development | synapse assembly | glycerolipid biosynthetic process | canonical Wnt receptor signaling pathway | positive regulation of membrane potential | dendritic spine organization | regulation of mitosis | multicellular organismal reproductive process | negative regulation of apoptotic process | negative regulation of phosphorus metabolic process | regulation of proteolysis | regulation of cell cycle | response to growth factor stimulus | positive regulation of catalytic activity | negative regulation of cell migration | myelin maintenance | regulation of neuron projection development | regulation of nucleobase-containing compound metabolic process | cellular response to chemical stimulus | central nervous system myelination | negative regulation of cellular metabolic process | tissue development | regulation of neurological system process | regulation of cell differentiation | regulation of system process | inositol phosphate catabolic process | regulation of lymphocyte apoptotic process | negative regulation of cell motility | regulation of protein kinase B signaling cascade | regulation of immune response | regulation of cellular process | cellular component organization or biogenesis | regulation of apoptotic process | regulation of metabolic process | gliogenesis | catabolic process | activation of mitotic anaphase-promoting complex activity | epidermal growth factor receptor signaling pathway | phosphorylated carbohydrate dephosphorylation | multi-multicellular organism process | positive regulation of cellular protein metabolic process | positive regulation of catabolic process | inositol phosphate phosphatase activity | cellular component organization | cellular lipid metabolic process | urogenital system development | phosphatase activity | negative regulation of transferase activity | negative regulation of protein modification process | response to stimulus | maternal behavior | protein tyrosine/serine/threonine phosphatase activity | negative regulation of cell communication | vasculature development | cell morphogenesis involved in neuron differentiation | phosphatidylinositol trisphosphate phosphatase activity | response to chemical stimulus | cellular response to fibroblast growth factor stimulus | oligodendrocyte development | positive regulation of immune system process | positive regulation of protein metabolic process | negative regulation of cell adhesion | postsynaptic density assembly | hydrolase activity | negative regulation of neurological system process | response to stress | negative regulation of dendritic spine morphogenesis | regulation of macromolecule biosynthetic process | endothelial cell migration | negative regulation of protein kinase activity | posttranscriptional regulation of gene expression | regulation of cell proliferation | regulation of response to external stimulus | regulation of protein ubiquitination | cardiac muscle tissue development | ensheathment of neurons | circadian rhythm | regulation of anatomical structure morphogenesis | axon ensheathment in central nervous system | programmed cell death | regulation of anatomical structure size | phosphatidylinositol-mediated signaling | phosphatidylinositol monophosphate phosphatase activity | reproduction | cardiovascular system development | rhythmic process | positive regulation of proteolysis | mitosis | immune response-activating signal transduction | ERBB signaling pathway | brain morphogenesis | response to endogenous stimulus | negative regulation of metabolic process | regulation of cellular component size | regulation of action potential in neuron | cellular component assembly | protein modification process | regulation of synaptic transmission | regulation of cell adhesion | cellular biosynthetic process | presynaptic membrane assembly | multi-organism behavior | macromolecule modification | cell-cell signaling | protein tyrosine phosphatase activity | catalytic activity | blood vessel development | regulation of membrane potential | locomotion | central nervous system neuron development | apoptotic process | protein kinase B signaling cascade | system development | regulation of cyclin-dependent protein kinase activity | reproductive process | regulation of signal transduction | positive regulation of organelle organization | Wnt receptor signaling pathway | negative regulation of growth | regulation of protein stability | negative regulation of phosphate metabolic process | myelination | multicellular organismal development | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | negative regulation of catalytic activity | cell migration | positive regulation of mitotic metaphase/anaphase transition | negative regulation of dendritic spine development | phosphorus metabolic process | learning or memory | cell cycle process | positive regulation of multicellular organismal process | regulation of axonogenesis | intracellular protein kinase cascade | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | lipid metabolic process | regulation of phosphorylation | fibroblast growth factor receptor signaling pathway | plasma membrane organization | cellular membrane organization | multicellular organismal reproductive behavior | telencephalon development | positive regulation of nuclear division | positive regulation of cell cycle | regulation of neuron differentiation | regulation of gene expression | interphase | rhythmic synaptic transmission | regulation of postsynaptic membrane potential | cellular component biogenesis | rhythmic behavior | neurological system process | cell cycle | negative regulation of cyclin-dependent protein kinase activity | organophosphate metabolic process | positive regulation of cellular metabolic process | regulation of multicellular organismal development | cellular ion homeostasis | organ morphogenesis | regulation of macromolecule metabolic process | phospholipid biosynthetic process | phosphoprotein phosphatase activity | regulation of transferase activity | regulation of myelination | regulation of nitrogen compound metabolic process | single-organism process | regulation of cell migration | regulation of cell-substrate adhesion | enzyme linked receptor protein signaling pathway | inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity | small molecule metabolic process | cellular carbohydrate metabolic process | activation of anaphase-promoting complex activity | negative regulation of protein serine/threonine kinase activity | regulation of cellular component movement | hydrolase activity, acting on ester bonds | multi-organism process | synapse organization | axonogenesis | cognition | negative regulation of ribosome biogenesis | synapse maturation | central nervous system myelin maintenance | biological regulation | cell proliferation | biosynthetic process | negative regulation of protein kinase B signaling cascade | locomotory behavior | regulation of primary metabolic process | cellular component movement | regulation of cellular protein metabolic process | inositol phosphate dephosphorylation | negative regulation of cell-substrate adhesion | glial cell differentiation | angiogenesis | interphase of mitotic cell cycle | regulation of synaptic vesicle clustering | lipid biosynthetic process | parental behavior | carbohydrate metabolic process | M phase of mitotic cell cycle | inositol lipid-mediated signaling | startle response | positive regulation of macromolecule metabolic process | phosphatidylinositol phosphate phosphatase activity | negative regulation of membrane potential | cell morphogenesis involved in differentiation | regulation of cellular catabolic process | positive regulation of biological process | phosphate-containing compound metabolic process | regulation of B cell apoptotic process | regulation of cellular macromolecule biosynthetic process | negative regulation of response to stimulus | negative regulation of developmental process | striated muscle tissue development | cell communication | regulation of cellular metabolic process | presynaptic membrane organization | regulation of protein kinase activity | induction of programmed cell death | dentate gyrus development | regulation of protein metabolic process | system process | heart development | lipid modification | homeostatic process | limbic system development | G1/S transition of mitotic cell cycle | positive regulation of cell proliferation | regulation of protein phosphorylation | phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity | regulation of locomotion | glycerolipid metabolic process | regulation of RNA metabolic process | regulation of mitotic cell cycle | regulation of catabolic process | positive regulation of molecular function | regulation of proteasomal ubiquitin-dependent protein catabolic process | neuron differentiation | multicellular organism reproduction | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity | cellular component organization at cellular level | activation of immune response | multicellular organismal response to stress | regulation of cell morphogenesis involved in differentiation | negative regulation of epithelial cell proliferation | protein metabolic process | positive regulation of protein modification process | regulation of growth | response to organic substance | gland development | regulation of cyclin-dependent protein kinase activity involved in G1/S | negative regulation of cell projection organization | nerve growth factor receptor signaling pathway | glycerophospholipid biosynthetic process | phosphatidylinositol dephosphorylation | cellular developmental process | positive regulation of transmission of nerve impulse | regulation of cellular biosynthetic process | regulation of ion homeostasis | regulation of kinase activity | regulation of sequence-specific DNA binding transcription factor activity | regulation of intracellular protein kinase cascade | negative regulation of intracellular protein kinase cascade | phosphatidylinositol-3-phosphatase activity | regulation of focal adhesion assembly | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | anatomical structure development | regulation of multicellular organismal process | regulation of dendrite morphogenesis | mitotic cell cycle | cell surface receptor signaling pathway | reproductive behavior | nuclear division | cell projection organization | metabolic process | primary metabolic process | phosphoric ester hydrolase activity | positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process | regulation of protein catabolic process | regulation of homeostatic process | regulation of RNA biosynthetic process | developmental maturation | negative regulation of programmed cell death | regulation of proteasomal protein catabolic process | mating behavior | negative regulation of cell size | oligodendrocyte differentiation | chemical homeostasis | behavior | positive regulation of cell death | membrane depolarization | regulation of myeloid cell apoptotic process | cellular response to stimulus | single organism reproductive process | dendritic spine morphogenesis | neuron projection development | mating | cellular component morphogenesis | induction of apoptosis | neuron-neuron synaptic transmission | cell death | regulation of interphase of mitotic cell cycle | regulation of leukocyte apoptotic process | organ development | forebrain development | pallium development | negative regulation of cellular protein metabolic process | negative regulation of synaptic vesicle clustering | negative regulation of cellular component movement | cellular response to endogenous stimulus | positive regulation of programmed cell death | ion homeostasis | regulation of phosphate metabolic process | cytoskeleton organization | phosphatidylinositol biosynthetic process | regulation of nuclear division | negative regulation of biological process | antigen receptor-mediated signaling pathway | negative regulation of cyclin-dependent protein kinase activity involved in G1/S | negative regulation of cell aging | growth | positive regulation of excitatory postsynaptic membrane potential | dendrite morphogenesis | anatomical structure formation involved in morphogenesis | negative regulation of cell cycle | negative regulation of protein metabolic process | regulation of dendrite development | regulation of cell communication | dephosphorylation | negative regulation of molecular function | negative regulation of signal transduction | regulation of action potential | regulation of dendritic spine development | signaling | regulation of transcription, DNA-dependent | glial cell development | negative regulation of macromolecule metabolic process | neuromuscular process | cell development | single-organism behavior | regulation of molecular function | regulation of epithelial cell proliferation | cellular component organization or biogenesis at cellular level | cellular protein metabolic process | regulation of cell size | anatomical structure morphogenesis | prostate gland development | positive regulation of response to stimulus | regulation of organ growth | reproductive structure development | dendrite development | regulation of nervous system development | regulation of developmental process | glycerophospholipid metabolic process | developmental process | response to external stimulus | organelle organization | localization of cell | positive regulation of cell cycle process | multi-organism reproductive process | cellular protein modification process | negative regulation of focal adhesion assembly | positive regulation of cellular process | negative regulation of cell proliferation | peptidyl-tyrosine dephosphorylation | regulation of cellular component biogenesis | regulation of mitotic metaphase/anaphase transition | response to fibroblast growth factor stimulus | circadian behavior | male mating behavior | single-multicellular organism process | single organism signaling | transmission of nerve impulse | positive regulation of ubiquitin-protein ligase activity | central nervous system development | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | regulation of synaptic plasticity | M phase | cellular component assembly at cellular level | phospholipid dephosphorylation | locomotor rhythm | regulation of cell projection organization | immune system process | regulation of ribosome biogenesis | cellular metabolic process | long-term synaptic potentiation | negative regulation of cell cycle process | cellular response to organic substance | regulation of cell death | negative regulation of cell death | negative regulation of cell development | circulatory system development | postsynaptic density organization | negative regulation of myelination | regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process | negative regulation of locomotion | positive regulation of protein ubiquitination | negative regulation of cell differentiation | regulation of cellular component organization | positive regulation of signaling | inositol phosphate metabolic process | positive regulation of mitosis | signal transduction | regulation of signaling | regulation of phosphatidylinositol 3-kinase cascade | regulation of cell-matrix adhesion | cellular response to growth factor stimulus | negative regulation of neurogenesis | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

internal side of plasma membrane | myelin sheath adaxonal region | intracellular membrane-bounded organelle | plasma membrane part | neuron projection | cell | nuclear lumen | compact myelin | cytoplasm | intracellular organelle | nuclear body | cell projection | PML body | nuclear part | nucleoplasm | plasma membrane | organelle part | intracellular organelle part | organelle lumen | nucleoplasm part | membrane part | cell part | membrane-bounded organelle | nucleus | organelle | cell periphery | cytoplasmic part | membrane-enclosed lumen | intracellular organelle lumen | Schmidt-Lanterman incisure | cytosol | intracellular part | intracellular | myelin sheath | membrane