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QuickView for PPARG (gene)


Gene Symbol:
PPARG Homo sapiens Homo sapiens
Full name:
peroxisome proliferator-activated receptor gamma
Synonyms:
PPAR gamma, PPAR-GAMMA, PPARG1, PPARG2, PPARgamma, nuclear receptor subfamily 1 group C member 3, NR1C3, OTTHUMP00000185030, OTTHUMP00000185033, OTTHUMP00000185037, peroxisome proliferative activated receptor gamma, peroxisome proliferator-activated nuclear receptor gamma variant 1, peroxisome proliferator-activated receptor gamma, peroxisome proliferator-activated receptor gamma 1, CIMT1, GLM1
Genomic Location:
Chr 3: 12304349-12450855
Description:
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PP...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Gallus gallus Canis lupus familiaris Pan troglodytes Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
CUTL1 binding site geneset 4 CEBPB binding site geneset 2 HNF4A binding site geneset 1 POU2F1 binding site geneset 3 Unknown transcription factor binding site geneset 26 Unknown transcription factor binding site geneset 27 SRF binding site geneset 2 TAF TATA binding site geneset 2 TCF11 MAFG binding site geneset 1 PAX2 binding site geneset 2
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 3
3p25





GO Molecular Function

sequence-specific DNA binding | fatty acid binding | regulatory region DNA binding | transcription regulatory region DNA binding | sequence-specific DNA binding RNA polymerase II transcription factor activity | prostanoid receptor activity | icosanoid binding | long-chain fatty acid binding | prostaglandin receptor activity | retinoic acid receptor binding | ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity | cation binding | hormone receptor binding | transmembrane signaling receptor activity | carboxylic acid binding | enzyme binding | nucleic acid binding | lipid binding | G-protein coupled receptor activity | nucleic acid binding transcription factor activity | receptor binding | arachidonic acid binding | steroid hormone receptor activity | binding | chromatin binding | RNA polymerase II regulatory region DNA binding | DNA binding | signaling receptor activity | monocarboxylic acid binding | icosatetraenoic acid binding | nuclear hormone receptor binding | ion binding | organic cyclic compound binding | retinoid X receptor binding | receptor activity | molecular transducer activity | protein binding | zinc ion binding | sequence-specific DNA binding transcription factor activity | transcription factor binding | regulatory region nucleic acid binding | activating transcription factor binding | signal transducer activity | transition metal ion binding | icosanoid receptor activity | drug binding | metal ion binding | heterocyclic compound binding

GO Biological Process

RNA metabolic process | transcription from RNA polymerase II promoter | response to extracellular stimulus | DNA-dependent transcription, initiation | long-chain fatty acid transport | regulation of biological process | positive regulation of macromolecule biosynthetic process | regulation of cysteine-type endopeptidase activity | response to nutrient levels | negative regulation of sequestering of triglyceride | regulation of neurogenesis | regulation of cholesterol transport | positive regulation of apoptotic process | regulation of cell development | regulation of localization | regulation of biosynthetic process | positive regulation of sequence-specific DNA binding transcription factor activity | lipid transport | regulation of programmed cell death | establishment of localization | nucleic acid metabolic process | response to hormone stimulus | regulation of immune system process | myeloid cell differentiation | regulation of biological quality | negative regulation of cellular process | sequence-specific DNA binding RNA polymerase II transcription factor activity | positive regulation of fatty acid oxidation | positive regulation of developmental process | negative regulation of response to external stimulus | response to metal ion | cell differentiation | prostanoid receptor activity | cellular macromolecule metabolic process | defense response | nervous system development | response to drug | neurogenesis | glucose homeostasis | generation of neurons | peroxisome proliferator activated receptor signaling pathway | regulation of response to interferon-gamma | regulation of lipid transport | hormone-mediated signaling pathway | regulation of response to stimulus | prostaglandin receptor activity | positive regulation of cellular biosynthetic process | cellular process | death | negative regulation of inflammatory response | ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity | monocarboxylic acid transport | localization | regulation of defense response | cell maturation | protein transport | negative regulation of signaling | immune system development | macromolecule localization | regulation of response to cytokine stimulus | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of cholesterol storage | transmembrane signaling receptor activity | regulation of nucleobase-containing compound metabolic process | brown fat cell differentiation | cellular response to chemical stimulus | response to inorganic substance | negative regulation of cellular metabolic process | response to peptide hormone stimulus | tissue development | regulation of fat cell differentiation | regulation of cell differentiation | negative regulation of receptor biosynthetic process | regeneration | negative regulation of acute inflammatory response | regulation of immune response | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | regulation of interferon-gamma-mediated signaling pathway | low-density lipoprotein receptor particle metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | regulation of response to stress | epithelium development | cellular aromatic compound metabolic process | cellular lipid metabolic process | cellular response to metal ion | G-protein coupled receptor activity | negative regulation of transferase activity | response to stimulus | cellular response to lithium ion | negative regulation of cell communication | oxoacid metabolic process | nucleic acid binding transcription factor activity | negative regulation of response to interferon-gamma | monocarboxylic acid metabolic process | response to chemical stimulus | regulation of macrophage derived foam cell differentiation | transport | positive regulation of peptidase activity | response to cold | response to stress | regulation of macromolecule biosynthetic process | regulation of cell proliferation | positive regulation of nucleobase-containing compound metabolic process | regulation of response to external stimulus | positive regulation of cysteine-type endopeptidase activity | programmed cell death | macromolecule biosynthetic process | cellular response to inorganic substance | cardiovascular system development | response to temperature stimulus | cellular nitrogen compound metabolic process | lipoprotein transport | positive regulation of gliogenesis | cellular response to organic cyclic compound | blood circulation | G-protein coupled receptor signaling pathway | response to endogenous stimulus | negative regulation of metabolic process | hemopoiesis | steroid hormone receptor activity | steroid hormone mediated signaling pathway | cellular biosynthetic process | regulation of lipid storage | regulation of oligodendrocyte differentiation | receptor biosynthetic process | leukocyte differentiation | apoptotic process | cellular response to hormone stimulus | system development | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of growth | multicellular organismal development | negative regulation of catalytic activity | positive regulation of RNA metabolic process | cellular response to peptide hormone stimulus | regulation of peptidase activity | negative regulation of RNA metabolic process | response to purine-containing compound | cellular response to insulin stimulus | regulation of catalytic activity | lipid metabolic process | regulation of acute inflammatory response | monocyte differentiation | response to abiotic stimulus | regulation of cholesterol transporter activity | regulation of gene expression | fatty acid transport | organic substance transport | response to lipid | regulation of blood pressure | myeloid leukocyte differentiation | positive regulation of cellular metabolic process | regulation of telomerase activity | regulation of multicellular organismal development | negative regulation of lipid storage | organ morphogenesis | negative regulation of smooth muscle cell proliferation | regulation of macromolecule metabolic process | regulation of transferase activity | signaling receptor activity | regulation of nitrogen compound metabolic process | single-organism process | regulation of cysteine-type endopeptidase activity involved in apoptotic process | small molecule metabolic process | negative regulation of nitrogen compound metabolic process | regulation of transcription from RNA polymerase II promoter | response to nutrient | response to lithium ion | fat cell differentiation | organic acid transport | positive regulation of hydrolase activity | regulation of fatty acid metabolic process | positive regulation of cell differentiation | biological regulation | cellular ketone metabolic process | biosynthetic process | regulation of primary metabolic process | response to vitamin A | positive regulation of endopeptidase activity | positive regulation of macromolecule metabolic process | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | positive regulation of biological process | regulation of cellular macromolecule biosynthetic process | negative regulation of response to stimulus | negative regulation of developmental process | response to estrogen stimulus | negative regulation of nucleobase-containing compound metabolic process | low-density lipoprotein particle receptor biosynthetic process | cell communication | regulation of cellular metabolic process | induction of programmed cell death | system process | positive regulation of biosynthetic process | heart development | lipid modification | homeostatic process | regulation of cytokine-mediated signaling pathway | regulation of sequestering of triglyceride | regulation of RNA metabolic process | negative regulation of cell growth | carboxylic acid metabolic process | positive regulation of molecular function | negative regulation of interferon-gamma-mediated signaling pathway | response to low-density lipoprotein particle stimulus | sequence-specific DNA binding transcription factor activity | regulation of growth | response to organic substance | regulation of innate immune response | cellular developmental process | regulation of cellular biosynthetic process | negative regulation of macromolecule biosynthetic process | positive regulation of fatty acid metabolic process | regulation of sequence-specific DNA binding transcription factor activity | response to insulin stimulus | anatomical structure development | regulation of multicellular organismal process | cell surface receptor signaling pathway | positive regulation of neurogenesis | negative regulation of response to cytokine stimulus | signal transducer activity | metabolic process | lipid localization | positive regulation of cell development | cell fate commitment | regulation of receptor biosynthetic process | primary metabolic process | activation of cysteine-type endopeptidase activity involved in apoptotic process | regulation of RNA biosynthetic process | circulatory system process | developmental maturation | oxidation-reduction process | negative regulation of transcription, DNA-dependent | positive regulation of glial cell differentiation | chemical homeostasis | positive regulation of cell death | immune response | cellular response to stimulus | nucleobase-containing compound metabolic process | response to caffeine | organic substance metabolic process | regulation of hydrolase activity | induction of apoptosis | cell death | response to vitamin | negative regulation of biosynthetic process | negative regulation of gene expression | organ development | gene expression | cellular response to endogenous stimulus | positive regulation of programmed cell death | regulation of fatty acid oxidation | response to lipoprotein particle stimulus | response to alkaloid | cellular response to steroid hormone stimulus | negative regulation of biological process | fatty acid metabolic process | establishment of protein localization | transcription initiation from RNA polymerase II promoter | transcription, DNA-dependent | regulation of cholesterol storage | lipid oxidation | intracellular receptor mediated signaling pathway | regulation of glial cell differentiation | negative regulation of macrophage derived foam cell differentiation | regulation of cell communication | regulation of gliogenesis | negative regulation of molecular function | negative regulation of signal transduction | signaling | regulation of transcription, DNA-dependent | response to organic cyclic compound | negative regulation of macromolecule metabolic process | cell development | regulation of molecular function | protein localization | organic acid metabolic process | carboxylic acid transport | anatomical structure morphogenesis | regulation of endopeptidase activity | cellular macromolecule biosynthetic process | positive regulation of fat cell differentiation | icosanoid receptor activity | regulation of cellular ketone metabolic process | regulation of nervous system development | regulation of developmental process | developmental process | response to external stimulus | regulation of sterol transport | regulation of cell growth | negative regulation of cellular biosynthetic process | white fat cell differentiation | positive regulation of oligodendrocyte differentiation | positive regulation of cellular process | negative regulation of transcription from RNA polymerase II promoter | regulation of transport | positive regulation of transcription, DNA-dependent | negative regulation of cell proliferation | innate immune response | receptor metabolic process | epithelial cell differentiation | single-multicellular organism process | single organism signaling | positive regulation of transcription from RNA polymerase II promoter | negative regulation of cytokine-mediated signaling pathway | negative regulation of defense response | heterocycle metabolic process | fatty acid oxidation | negative regulation of cellular macromolecule biosynthetic process | regulation of transporter activity | regulation of lipid metabolic process | positive regulation of metabolic process | positive regulation of lipid metabolic process | immune system process | cellular metabolic process | hemopoietic or lymphoid organ development | placenta development | cellular response to organic substance | regulation of cell death | regulation of smooth muscle cell proliferation | response to steroid hormone stimulus | circulatory system development | regulation of inflammatory response | carbohydrate homeostasis | negative regulation of telomerase activity | activation of cysteine-type endopeptidase activity | lipid homeostasis | negative regulation of cell differentiation | regulation of cellular component organization | signal transduction | regulation of signaling | organ regeneration | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nuclear part | nucleoplasm | organelle part | intracellular organelle part | organelle lumen | cell part | membrane-bounded organelle | nucleus | organelle | cytoplasmic part | membrane-enclosed lumen | intracellular organelle lumen | cytosol | intracellular part | intracellular