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QuickView for PPARA (gene)


Gene Symbol:
PPARA Homo sapiens Homo sapiens
Full name:
peroxisome proliferator-activated receptor alpha
Synonyms:
hPPAR, OTTHUMP00000042872, OTTHUMP00000197740, OTTHUMP00000197741, OTTHUMP00000028713, PPAR, PPAR-alpha, PPARalpha, NR1C1, MGC2237, MGC2452, peroxisome proliferative activated receptor, alpha, peroxisome proliferator-activated nuclear receptor alpha variant 3, peroxisome proliferator-activated receptor alpha, nuclear receptor subfamily 1 group C member 1, SC22CB-5E3.5
Genomic Location:
Chr 22: 44925163-45018317
Description:
Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The act...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Gallus gallus Canis lupus familiaris Pan troglodytes Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
HNF4A binding site geneset 1 ESR1 binding site geneset 1 HNF4A binding site geneset 3 HNF4A binding site geneset 4 TCF3 binding site geneset 3 AR binding site geneset 3 MYOD1 binding site geneset 3 Targets of MicroRNA GCACTTT,MIR-17-5P,MIR-20A,MIR-106A,MIR-106B,MIR-20B,MIR-519D Targets of MicroRNA ACTGTGA,MIR-27A,MIR-27B Targets of MicroRNA TTTGCAC,MIR-19A,MIR-19B
miRNA binding sites
(Source: TargetScan):
miRNA binding sites
(Source: miRecords):
Cytogenetic Map:
chr 22
22q13.31





GO Molecular Function

sequence-specific DNA binding | sequence-specific DNA binding RNA polymerase II transcription factor activity | ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity | cation binding | repressing transcription factor binding | enzyme binding | nucleic acid binding | lipid binding | nucleic acid binding transcription factor activity | steroid hormone receptor activity | binding | protein domain specific binding | RNA polymerase II repressing transcription factor binding | ubiquitin conjugating enzyme binding | DNA binding | signaling receptor activity | ion binding | organic cyclic compound binding | receptor activity | molecular transducer activity | protein binding | zinc ion binding | sequence-specific DNA binding transcription factor activity | transcription factor binding | RNA polymerase II transcription factor binding | signal transducer activity | small protein conjugating enzyme binding | transition metal ion binding | drug binding | metal ion binding | heterocyclic compound binding

GO Biological Process

RNA metabolic process | transcription from RNA polymerase II promoter | regulation of cellular ketone metabolic process by regulation of transcription from RNA polymerase II promoter | response to extracellular stimulus | positive regulation of cellular catabolic process | DNA-dependent transcription, initiation | regulation of biological process | positive regulation of macromolecule biosynthetic process | response to nutrient levels | negative regulation of sequestering of triglyceride | regulation of localization | regulation of biosynthetic process | regulation of carbohydrate metabolic process | lipid transport | positive regulation of lipid catabolic process | regulation of carbohydrate catabolic process | establishment of localization | nucleic acid metabolic process | response to hormone stimulus | regulation of biological quality | negative regulation of cellular process | sequence-specific DNA binding RNA polymerase II transcription factor activity | positive regulation of fatty acid oxidation | negative regulation of response to external stimulus | cellular macromolecule metabolic process | regulation of lipid transport | hormone-mediated signaling pathway | regulation of response to stimulus | positive regulation of cellular biosynthetic process | cellular process | negative regulation of response to extracellular stimulus | ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity | monocarboxylic acid transport | localization | regulation of glycolysis | odontogenesis | macromolecule localization | response to hypoxia | tooth mineralization | positive regulation of nitrogen compound metabolic process | regulation of appetite | negative regulation of cholesterol storage | regulation of nucleobase-containing compound metabolic process | cellular response to chemical stimulus | negative regulation of cellular metabolic process | response to peptide hormone stimulus | tissue development | regulation of cell differentiation | negative regulation of receptor biosynthetic process | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | negative regulation of appetite | cellular aromatic compound metabolic process | positive regulation of catabolic process | cellular lipid metabolic process | response to stimulus | oxoacid metabolic process | nucleic acid binding transcription factor activity | monocarboxylic acid metabolic process | response to chemical stimulus | regulation of macrophage derived foam cell differentiation | transport | response to stress | regulation of macromolecule biosynthetic process | positive regulation of nucleobase-containing compound metabolic process | regulation of response to external stimulus | macromolecule biosynthetic process | cardiovascular system development | cellular nitrogen compound metabolic process | regulation of response to extracellular stimulus | blood circulation | response to endogenous stimulus | negative regulation of metabolic process | steroid hormone receptor activity | steroid hormone mediated signaling pathway | response to decreased oxygen levels | cellular biosynthetic process | regulation of lipid storage | negative regulation of blood pressure | cellular response to hormone stimulus | system development | response to oxygen levels | nitrogen compound metabolic process | regulation of fatty acid beta-oxidation | multicellular organismal development | positive regulation of RNA metabolic process | negative regulation of RNA metabolic process | lipid metabolic process | regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter | wound healing | response to abiotic stimulus | regulation of gene expression | fatty acid transport | organic substance transport | regulation of response to food | regulation of blood pressure | positive regulation of cellular metabolic process | negative regulation of lipid storage | organ morphogenesis | regulation of macromolecule metabolic process | amelogenesis | signaling receptor activity | regulation of nitrogen compound metabolic process | single-organism process | small molecule metabolic process | negative regulation of nitrogen compound metabolic process | regulation of cellular carbohydrate metabolic process | regulation of transcription from RNA polymerase II promoter | organic acid transport | negative regulation of catabolic process | regulation of fatty acid metabolic process | regulation of glycolysis by regulation of transcription from RNA polymerase II promoter | biological regulation | cellular ketone metabolic process | biosynthetic process | regulation of primary metabolic process | positive regulation of macromolecule metabolic process | epidermis development | regulation of cellular catabolic process | positive regulation of biological process | regulation of cellular macromolecule biosynthetic process | negative regulation of response to stimulus | negative regulation of developmental process | regulation of glycolysis by positive regulation of transcription from RNA polymerase II promoter | negative regulation of nucleobase-containing compound metabolic process | regulation of response to nutrient levels | cell communication | regulation of cellular metabolic process | regulation of lipid catabolic process | lipoprotein metabolic process | odontogenesis of dentin-containing tooth | system process | positive regulation of biosynthetic process | heart development | regulation of sequestering of triglyceride | regulation of RNA metabolic process | regulation of catabolic process | carboxylic acid metabolic process | regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter | negative regulation of carbohydrate metabolic process | sequence-specific DNA binding transcription factor activity | negative regulation of response to food | response to organic substance | positive regulation of fatty acid beta-oxidation | regulation of cellular biosynthetic process | negative regulation of macromolecule biosynthetic process | response to wounding | positive regulation of fatty acid metabolic process | response to insulin stimulus | anatomical structure development | regulation of glucose metabolic process | signal transducer activity | metabolic process | lipid localization | regulation of receptor biosynthetic process | primary metabolic process | regulation of RNA biosynthetic process | circulatory system process | negative regulation of transcription, DNA-dependent | regulation of lipid transport by regulation of transcription from RNA polymerase II promoter | cellular response to stimulus | negative regulation of glycolysis | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | organ development | gene expression | cellular response to endogenous stimulus | regulation of cellular carbohydrate catabolic process | regulation of fatty acid oxidation | biomineral tissue development | cellular response to steroid hormone stimulus | negative regulation of biological process | fatty acid metabolic process | transcription initiation from RNA polymerase II promoter | transcription, DNA-dependent | regulation of cholesterol storage | negative regulation of cellular catabolic process | intracellular receptor mediated signaling pathway | negative regulation of response to nutrient levels | anatomical structure formation involved in morphogenesis | negative regulation of macrophage derived foam cell differentiation | signaling | regulation of transcription, DNA-dependent | negative regulation of macromolecule metabolic process | organic acid metabolic process | carboxylic acid transport | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | regulation of cellular ketone metabolic process | regulation of developmental process | developmental process | response to external stimulus | negative regulation of cellular biosynthetic process | positive regulation of cellular process | negative regulation of transcription from RNA polymerase II promoter | regulation of transport | positive regulation of transcription, DNA-dependent | single-multicellular organism process | single organism signaling | positive regulation of transcription from RNA polymerase II promoter | heterocycle metabolic process | negative regulation of cellular carbohydrate metabolic process | negative regulation of cellular macromolecule biosynthetic process | regulation of generation of precursor metabolites and energy | regulation of lipid metabolic process | positive regulation of metabolic process | positive regulation of lipid metabolic process | cellular metabolic process | cellular response to organic substance | enamel mineralization | response to steroid hormone stimulus | circulatory system development | negative regulation of cell differentiation | signal transduction | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | cell | nuclear lumen | intracellular organelle | nuclear part | nucleoplasm | organelle part | intracellular organelle part | organelle lumen | cell part | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular organelle lumen | intracellular part | intracellular