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QuickView for Oxtriphylline (compound)


PubChem
Name: cholinophyllin
PubChem Compound ID: 20585
Molecular formula: C12H22N5O3+
Molecular weight: 284.335 g/mol
Synonyms:
Colina teofillinato [DCIT]; Soliphylline; Theophylline cholinate; Oxtriphylline; 146-71-4; 4499-40-5; Theoxylline; 13930-27-3; Brondecon; Cholegyl.
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DrugBank
Identification
Name: cholinophyllin
Name (isomeric): DB01303
Drug Type: small molecule
Synonyms:
Choline theophylline
Brand: Theocolin, Choledyl
Category: Bronchodilator Agents
CAS number: 4499-40-5
Pharmacology
Indication: Used to treat the symptoms of asthma, bronchitis, and emphysema.
Pharmacology: Oxtriphylline is a bronchodilator. Oxtriphylline works in several ways: it relaxes muscles in your lungs and chest to allow more air in, decreases the sensitivity of your lungs to allergens and other substances that cause inflammation, and increases the contractions of your diaphragm to draw more air into the lungs.
Mechanism of Action:
Oxtriphylline is a choline salt of theophylline. Oxtriphylline relaxes the smooth muscle of the bronchial airways and pulmonary blood vessels and reduces airway responsiveness to histamine, methacholine, adenosine, and allergen. Oxtriphylline competitively inhibits type III and type IV phosphodiesterase (PDE), the enzyme responsible for breaking d...
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Toxicity: Symptoms of toxicity include abdominal pain (continuing or severe), confusion or change in behavior, convulsions (seizures), dark or bloody vomit, diarrhea, dizziness or lightheadedness, fast and/or irregular heartbeat, nervousness or restlessness (continuing), and trembling (continuing).
Affected organisms: Humans and other mammals
Interactions
Food interaction:
Take with food to reduce irritation.
Avoid high doses of caffeine.
Drug interaction:
MestranolThe contraceptive increases the effect and toxicity of theophylline
VecuroniumTheophylline decreases the effect of muscle relaxant
ErythromycinThe macrolide, erythromycin, may increase the effect and toxicity of the theophylline derivative, oxtriphylline.
AtracuriumTheophylline decreases the effect of muscle relaxant
PropranololAntagonism of action and increased effect of theophylline
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