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QuickView for OTUD7C (gene)


Gene Symbol:
TNFAIP3 Homo sapiens Homo sapiens
Full name:
tumor necrosis factor, alpha-induced protein 3
Synonyms:
A20, MGC138687, MGC138688, MGC104522, OTTHUMP00000017289, OTU domain-containing protein 7C, OTUD7C, putative DNA-binding protein A20, tumor necrosis factor alpha-induced protein 3, tumor necrosis factor inducible protein A20, tumor necrosis factor, alpha-induced protein 3, RP11-356I2.3, TNF alpha-induced protein 3, TNFA1P2, zinc finger protein A20
Genomic Location:
Chr 6: 138230274-138246142
Description:
This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. Knockout studies of a similar gene in mice suggested that this gene is critical for limiting infl...
Orthologs:
Mus musculus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Cytogenetic Map:
chr 6
6q23





GO Molecular Function

protein self-association | endopeptidase inhibitor activity | thiolester hydrolase activity | kinase binding | cysteine-type endopeptidase inhibitor activity involved in apoptotic process | cation binding | enzyme binding | nucleic acid binding | enzyme inhibitor activity | hydrolase activity | acid-amino acid ligase activity | ubiquitin binding | binding | cysteine-type peptidase activity | catalytic activity | ligase activity, forming carbon-nitrogen bonds | small conjugating protein ligase activity | endopeptidase regulator activity | peptidase activity, acting on L-amino acid peptides | DNA binding | hydrolase activity, acting on ester bonds | small conjugating protein binding | small conjugating protein-specific protease activity | ubiquitin-specific protease activity | ion binding | organic cyclic compound binding | ubiquitin thiolesterase activity | protein binding | zinc ion binding | peptidase regulator activity | ligase activity | ubiquitin-protein ligase activity | transition metal ion binding | cysteine-type endopeptidase regulator activity involved in apoptotic process | peptidase inhibitor activity | enzyme regulator activity | protease binding | metal ion binding | heterocyclic compound binding | peptidase activity | cysteine-type endopeptidase inhibitor activity

GO Biological Process

positive regulation of immune response | protein modification by small protein removal | leukocyte homeostasis | negative regulation of leukocyte activation | nucleotide-binding oligomerization domain containing signaling pathway | negative regulation of phosphorylation | regulation of interleukin-1 beta production | cytoplasmic pattern recognition receptor signaling pathway | regulation of biological process | negative regulation of multicellular organismal process | regulation of cysteine-type endopeptidase activity | endopeptidase inhibitor activity | negative regulation of immune system process | thiolester hydrolase activity | regulation of B cell activation | immune response-regulating signaling pathway | response to lipopolysaccharide | negative regulation of type I interferon production | intracellular signal transduction | regulation of multi-organism process | proteolysis | regulation of biosynthetic process | regulation of programmed cell death | cysteine-type endopeptidase inhibitor activity involved in apoptotic process | negative regulation of cysteine-type endopeptidase activity | regulation of immune system process | regulation of biological quality | negative regulation of cellular process | negative regulation of kinase activity | negative regulation of response to external stimulus | positive regulation of epithelial cell proliferation | negative regulation of tissue remodeling | cellular macromolecule metabolic process | regulation of toll-like receptor 3 signaling pathway | defense response | tolerance induction to lipopolysaccharide | negative regulation of response to biotic stimulus | positive regulation of protein catabolic process | negative regulation of protein phosphorylation | regulation of protein modification process | negative regulation of chronic inflammatory response | negative regulation of toll-like receptor 4 signaling pathway | regulation of toll-like receptor 4 signaling pathway | regulation of bone remodeling | regulation of response to stimulus | innate immune response-activating signal transduction | cellular process | death | negative regulation of inflammatory response | regulation of defense response | negative regulation of signaling | anti-apoptosis | tolerance induction | immune system development | regulation of CD40 signaling pathway | negative regulation of apoptotic process | regulation of defense response to virus | macromolecular complex subunit organization | negative regulation of phosphorus metabolic process | regulation of hepatocyte proliferation | regulation of cell cycle | regulation of nucleobase-containing compound metabolic process | negative regulation of cellular metabolic process | negative regulation of osteoclast proliferation | negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway | regulation of osteoclast proliferation | regulation of angiogenesis | regulation of immune response | regulation of cellular process | cellular component organization or biogenesis | negative regulation of interleukin-1 production | regulation of apoptotic process | negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway | regulation of metabolic process | cellular response to molecule of bacterial origin | negative regulation of tumor necrosis factor production | negative regulation of toll-like receptor 5 signaling pathway | regulation of response to stress | positive regulation of catabolic process | negative regulation of bone resorption | cellular component organization | protein deubiquitination | negative regulation of toll-like receptor signaling pathway | regulation of type I interferon production | negative regulation of transferase activity | negative regulation of protein modification process | regulation of vasculature development | response to stimulus | enzyme inhibitor activity | negative regulation of cell communication | response to chemical stimulus | positive regulation of innate immune response | positive regulation of immune system process | positive regulation of protein metabolic process | regulation of leukocyte activation | protein complex assembly | regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway | hydrolase activity | response to stress | regulation of macromolecule biosynthetic process | negative regulation of lymphocyte activation | negative regulation of protein kinase activity | negative regulation of CD40 signaling pathway | regulation of cell proliferation | regulation of response to external stimulus | regulation of protein ubiquitination | regulation of anatomical structure morphogenesis | response to muramyl dipeptide | programmed cell death | acid-amino acid ligase activity | activation of innate immune response | response to molecule of bacterial origin | immune response-activating signal transduction | negative regulation of metabolic process | cellular component assembly | regulation of wound healing | protein modification process | protein complex subunit organization | macromolecule modification | negative regulation of toll-like receptor 2 signaling pathway | cysteine-type peptidase activity | catalytic activity | negative regulation of NF-kappaB transcription factor activity | apoptotic process | system development | regulation of cyclin-dependent protein kinase activity | ligase activity, forming carbon-nitrogen bonds | regulation of signal transduction | pattern recognition receptor signaling pathway | negative regulation of phosphate metabolic process | small conjugating protein ligase activity | endopeptidase regulator activity | negative regulation of interleukin-6 production | multicellular organismal development | negative regulation of catalytic activity | regulation of toll-like receptor signaling pathway | regulation of peptidase activity | protein oligomerization | negative regulation of nucleotide-binding oligomerization domain containing signaling pathway | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | peptidase activity, acting on L-amino acid peptides | negative regulation of peptidase activity | regulation of gene expression | cellular component biogenesis | negative regulation of cyclin-dependent protein kinase activity | negative regulation of cytokine production | regulation of multicellular organismal development | regulation of lymphocyte activation | negative regulation of smooth muscle cell proliferation | regulation of macromolecule metabolic process | response to peptidoglycan | regulation of transferase activity | regulation of germinal center formation | regulation of interleukin-2 production | protein complex biogenesis | regulation of nitrogen compound metabolic process | single-organism process | protein modification by small protein conjugation | regulation of cysteine-type endopeptidase activity involved in apoptotic process | negative regulation of sequence-specific DNA binding transcription factor activity | negative regulation of protein serine/threonine kinase activity | regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway | regulation of endothelial cell apoptotic process | hydrolase activity, acting on ester bonds | multi-organism process | negative regulation of toll-like receptor 3 signaling pathway | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | B cell homeostasis | homeostasis of number of cells | small conjugating protein-specific protease activity | biological regulation | regulation of primary metabolic process | regulation of cellular protein metabolic process | negative regulation of homeostatic process | ubiquitin-specific protease activity | positive regulation of macromolecule metabolic process | regulation of tumor necrosis factor production | positive regulation of biological process | regulation of cellular macromolecule biosynthetic process | negative regulation of response to stimulus | response to bacterium | regulation of interleukin-1 production | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | positive regulation of defense response | lymphocyte homeostasis | negative regulation of cell activation | inflammatory response | regulation of protein metabolic process | ubiquitin thiolesterase activity | negative regulation of interleukin-2 production | homeostatic process | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of RNA metabolic process | negative regulation of protein ubiquitination | regulation of nucleotide-binding oligomerization domain containing signaling pathway | negative regulation of B cell activation | regulation of catabolic process | protein polyubiquitination | macromolecular complex assembly | activation of immune response | nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | protein metabolic process | protein K63-linked deubiquitination | response to organic substance | regulation of innate immune response | protein ubiquitination | regulation of cellular biosynthetic process | regulation of kinase activity | response to wounding | regulation of lipopolysaccharide-mediated signaling pathway | peptidase regulator activity | regulation of organ morphogenesis | regulation of sequence-specific DNA binding transcription factor activity | regulation of intracellular protein kinase cascade | negative regulation of intracellular protein kinase cascade | regulation of immune effector process | anatomical structure development | regulation of multicellular organismal process | ligase activity | regulation of chronic inflammatory response | metabolic process | negative regulation of I-kappaB kinase/NF-kappaB cascade | primary metabolic process | ubiquitin-protein ligase activity | regulation of protein catabolic process | regulation of homeostatic process | regulation of adaptive immune response | negative regulation of leukocyte proliferation | regulation of RNA biosynthetic process | negative regulation of programmed cell death | regulation of bone resorption | regulation of tissue remodeling | immune response | cellular response to stimulus | regulation of hydrolase activity | cell death | regulation of toll-like receptor 5 signaling pathway | negative regulation of cellular protein metabolic process | regulation of cell activation | protein modification by small protein conjugation or removal | regulation of phosphate metabolic process | negative regulation of biological process | intracellular receptor mediated signaling pathway | negative regulation of cell cycle | negative regulation of protein metabolic process | regulation of toll-like receptor 2 signaling pathway | regulation of cell communication | cysteine-type endopeptidase regulator activity involved in apoptotic process | negative regulation of molecular function | negative regulation of signal transduction | signaling | regulation of transcription, DNA-dependent | negative regulation of macromolecule metabolic process | regulation of molecular function | regulation of epithelial cell proliferation | peptidase inhibitor activity | cellular protein metabolic process | enzyme regulator activity | regulation of cytokine production | regulation of endopeptidase activity | positive regulation of response to stimulus | response to biotic stimulus | regulation of developmental process | developmental process | regulation of response to biotic stimulus | cellular protein modification process | regulation of leukocyte proliferation | negative regulation of interleukin-1 beta production | positive regulation of cellular process | negative regulation of cell proliferation | innate immune response | regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | single-multicellular organism process | single organism signaling | regulation of defense response to virus by host | regulation of vascular wound healing | negative regulation of defense response | positive regulation of hepatocyte proliferation | negative regulation of hydrolase activity | protein K48-linked ubiquitination | negative regulation of bone remodeling | positive regulation of metabolic process | cellular response to biotic stimulus | immune system process | cellular metabolic process | negative regulation of lipopolysaccharide-mediated signaling pathway | peptidase activity | regulation of cell death | regulation of smooth muscle cell proliferation | cysteine-type endopeptidase inhibitor activity | negative regulation of cell death | regulation of interleukin-6 production | regulation of inflammatory response | B-1 B cell homeostasis | regulation of I-kappaB kinase/NF-kappaB cascade | response to other organism | signal transduction | regulation of signaling | negative regulation of endopeptidase activity | negative regulation of endothelial cell apoptotic process | cellular response to lipopolysaccharide | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | microtubule organizing center | cell | intracellular non-membrane-bounded organelle | cytoplasm | intracellular organelle | centrosome | organelle part | intracellular organelle part | vacuole | microtubule cytoskeleton | lytic vacuole | cell part | membrane-bounded organelle | nucleus | organelle | lysosome | cytoplasmic part | non-membrane-bounded organelle | cytosol | cytoskeleton | intracellular part | intracellular | cytoskeletal part