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PubChem
Name: Nafcillin
PubChem Compound ID: 4636599
Description: A semi-synthetic antibiotic related to penicillin.
Molecular formula: C21H21N2O5S-
Molecular weight: 413.468 g/mol
DrugBank
Identification
Name: Nafcillin
Name (isomeric): DB00607
Drug Type: small molecule
Description: A semi-synthetic antibiotic related to penicillin.
Synonyms:
Nafcillin Sodium; Nafcilline [INN-French]; Nafcilina [INN-Spanish]; Nafcillinum [INN-Latin]; Nafcillin sodium salt
Brand: Nallpen In Plastic Container, Naphcillin, Nafcilin-1, Nafcillin sodium for injection, Unipen, Nallpen
Category: Anti-Bacterial Agents, Penicillins
CAS number: 985-16-0
Pharmacology
Indication: For the treatment of infections caused by penicillinase-producing staphylococci which have demonstrated susceptibility to the drugs.
Pharmacology:
Nafcillin is a semisynthetic antibiotic substance derived from 6-amino-penicillanic acid. The drugs in this class are highly resistant to inactivation by staphylococcal penicillinase and are active against penicillinase-producing and non penicillinase-producing strains of Staphylococcus aureus. The penicillinase- resistant penicillins are active in...
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Mechanism of Action: Penicillinase-resistant penicillins exert a bactericidal action against penicillin-susceptible microorganisms during the state of active multiplication. All penicillins inhibit the biosynthesis of the bacterial cell wall.
Protein binding: 89.9 ±1.5%
Biotransformation: Hepatic metabolism accounts for less than 30% of the biotransformation of most penicillins.
Route of elimination: Nafcillin is primarily eliminated by nonrenal routes, namely hepatic inactivation and excretion in the bile.
Half Life: The serum half-life of nafcillin administered by the intravenous route ranged from 33 to 61 minutes as measured in three separate studies.
Toxicity: Serious toxicity is unlikely following large doses of nafcillin. Acute ingestion of large doses of nafcillin may cause nausea, vomiting, diarrhea and abdominal pain. Acute oliguric renal failure and hematuria may occur following large doses.
Affected organisms: Enteric bacteria and other eubacteria
Interactions
Drug interaction:
Ethinyl EstradiolThis anti-infectious agent could decrease the effect of the oral contraceptive
TemsirolimusNafcillin may increase the metabolism of Temsirolimus decreasing its efficacy. Concomitant therapy should be avoided.
WarfarinNafcillin may increase the anticoagulant effect of warfarin increasing the risk of bleeding. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of warfarin if nafcillin is initiated, discontinued or dose changed.
TramadolNafcillin may decrease the effect of Tramadol by increasing Tramadol metabolism and clearance.
MinocyclinePossible antagonism of action
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