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QuickView for NR3C1 (gene)


Gene Symbol:
NR3C1 Homo sapiens Homo sapiens
Full name:
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Synonyms:
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor), GCCR, GCR, glucocorticoid nuclear receptor variant 1, glucocorticoid receptor, GRL, GR
Genomic Location:
Chr 5: 142637689-142795270
Description:
The protein encoded by this gene is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Unknown transcription factor binding site geneset 3 Unknown transcription factor binding site geneset 19 GATA1 binding site geneset 4 AHR binding site geneset 1 CEBPA binding site geneset 2 CREB1 binding site geneset 3 Unknown transcription factor binding site geneset 41 AHR binding site geneset 2 LMO2 binding site geneset 2 GATA1 binding site geneset 6
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 5
5q31.3





GO Molecular Function

sequence-specific DNA binding | cation binding | receptor tyrosine kinase binding | nucleic acid binding | lipid binding | nucleic acid binding transcription factor activity | receptor binding | steroid hormone receptor activity | binding | chromatin binding | glucocorticoid receptor activity | Hsp70 protein binding | structure-specific DNA binding | DNA binding | signaling receptor activity | identical protein binding | protein heterodimerization activity | ion binding | organic cyclic compound binding | receptor activity | molecular transducer activity | protein binding | protein homodimerization activity | zinc ion binding | double-stranded DNA binding | sequence-specific DNA binding transcription factor activity | protein dimerization activity | signal transducer activity | transition metal ion binding | Hsp90 protein binding | steroid binding | heat shock protein binding | metal ion binding | heterocyclic compound binding

GO Biological Process

RNA metabolic process | transcription from RNA polymerase II promoter | brain development | DNA-dependent transcription, initiation | response to radiation | regulation of biological process | positive regulation of macromolecule biosynthetic process | regulation of cellular localization | positive regulation of apoptotic process | regulation of localization | mammary gland duct morphogenesis | morphogenesis of an epithelium | regulation of biosynthetic process | regulation of carbohydrate metabolic process | regulation of programmed cell death | cellular hormone metabolic process | nucleic acid metabolic process | response to hormone stimulus | regulation of transforming growth factor beta receptor signaling pathway | regulation of biological quality | negative regulation of cellular process | glucocorticoid mediated signaling pathway | response to metal ion | respiratory tube development | cellular macromolecule metabolic process | nervous system development | hormone-mediated signaling pathway | regulation of response to stimulus | regulation of neuron death | positive regulation of cellular biosynthetic process | cellular process | regulation of gene expression, epigenetic | response to magnesium ion | regulation of steroid hormone biosynthetic process | epithelial tube morphogenesis | chromatin organization | negative regulation of signaling | anti-apoptosis | negative regulation of apoptotic process | response to corticosterone stimulus | positive regulation of nitrogen compound metabolic process | regulation of nucleobase-containing compound metabolic process | cellular response to chemical stimulus | response to inorganic substance | response to peptide hormone stimulus | tissue development | regulation of cellular process | cellular component organization or biogenesis | regulation of apoptotic process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | epithelium development | cellular aromatic compound metabolic process | cellular component organization | cellular response to metal ion | mammary gland morphogenesis | response to stimulus | negative regulation of cell communication | nucleic acid binding transcription factor activity | response to chemical stimulus | respiratory system development | muscle adaptation | gland morphogenesis | regulation of macromolecule biosynthetic process | regulation of cell proliferation | positive regulation of nucleobase-containing compound metabolic process | tube morphogenesis | circadian rhythm | macromolecule biosynthetic process | cellular response to inorganic substance | rhythmic process | cellular nitrogen compound metabolic process | blood circulation | corticosteroid receptor signaling pathway | response to endogenous stimulus | steroid hormone receptor activity | steroid hormone mediated signaling pathway | regulation of steroid biosynthetic process | cellular biosynthetic process | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | regulation of steroid metabolic process | glucocorticoid receptor activity | cellular response to hormone stimulus | system development | nitrogen compound metabolic process | regulation of signal transduction | multicellular organismal development | response to activity | positive regulation of RNA metabolic process | mammary gland development | positive regulation of glutamate secretion | lipid metabolic process | regulation of hormone levels | response to abiotic stimulus | regulation of gene expression | positive regulation of secretion | positive regulation of cellular metabolic process | chromatin-mediated maintenance of transcription | regulation of macromolecule metabolic process | response to mercury ion | signaling receptor activity | regulation of nitrogen compound metabolic process | single-organism process | regulation of vascular permeability | regulation of cellular carbohydrate metabolic process | response to corticosteroid stimulus | positive regulation of gene expression, epigenetic | glucocorticoid receptor signaling pathway | chromatin modification | biological regulation | biosynthetic process | regulation of primary metabolic process | regulation of hormone metabolic process | cellular response to glucocorticoid stimulus | positive regulation of neuron death | positive regulation of macromolecule metabolic process | regulation of glutamate secretion | endocrine system development | cellular response to corticosteroid stimulus | positive regulation of biological process | regulation of cellular macromolecule biosynthetic process | negative regulation of response to stimulus | cell communication | regulation of cellular metabolic process | chromatin remodeling | regulation of neuron apoptotic process | system process | positive regulation of biosynthetic process | regulation of carbohydrate biosynthetic process | regulation of RNA metabolic process | positive regulation of transport | regulation of lipid biosynthetic process | cellular component organization at cellular level | regulation of glucocorticoid biosynthetic process | sequence-specific DNA binding transcription factor activity | negative regulation of transforming growth factor beta receptor signaling pathway | response to organic substance | gland development | regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | tissue morphogenesis | regulation of cellular biosynthetic process | positive regulation of neuron apoptotic process | response to insulin stimulus | anatomical structure development | regulation of glucose metabolic process | signal transducer activity | metabolic process | primary metabolic process | response to mineralocorticoid stimulus | regulation of RNA biosynthetic process | circulatory system process | negative regulation of programmed cell death | adrenal gland development | regulation of secretion | positive regulation of cell death | cellular response to stimulus | nucleobase-containing compound metabolic process | organic substance metabolic process | organ development | C21-steroid hormone metabolic process | gene expression | muscle atrophy | cellular response to endogenous stimulus | positive regulation of programmed cell death | mammary gland epithelium development | cellular response to steroid hormone stimulus | negative regulation of biological process | negative regulation of vascular permeability | transcription initiation from RNA polymerase II promoter | transcription, DNA-dependent | lung development | intracellular receptor mediated signaling pathway | anatomical structure formation involved in morphogenesis | steroid metabolic process | regulation of cell communication | negative regulation of signal transduction | response to arsenic-containing substance | signaling | glucocorticoid metabolic process | regulation of transcription, DNA-dependent | cellular component organization or biogenesis at cellular level | hormone metabolic process | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | regulation of cellular ketone metabolic process | developmental process | organelle organization | intracellular steroid hormone receptor signaling pathway | positive regulation of cellular process | tube development | regulation of transport | positive regulation of transcription, DNA-dependent | single-multicellular organism process | single organism signaling | heterocycle metabolic process | regulation of gluconeogenesis | central nervous system development | regulation of lipid metabolic process | positive regulation of metabolic process | chromosome organization | vascular process in circulatory system | cellular metabolic process | regulation of glucocorticoid metabolic process | cellular response to organic substance | regulation of cell death | response to steroid hormone stimulus | negative regulation of cell death | aging | muscle system process | signal transduction | regulation of signaling | positive regulation of gene expression | response to glucocorticoid stimulus | regulation of hormone biosynthetic process | macromolecule metabolic process | multicellular organismal process | cellular response to magnesium ion

GO Cellular Component

dendritic spine | mitochondrial matrix | dendrite | intracellular membrane-bounded organelle | synapse | neuron projection | cell | mitochondrial part | nuclear lumen | nucleolus | intracellular non-membrane-bounded organelle | cell projection part | cytoplasm | intracellular organelle | synapse part | macromolecular complex | cell projection | neuron spine | nuclear part | nucleoplasm | organelle part | intracellular organelle part | organelle lumen | dendritic spine head | postsynaptic density | mitochondrion | cell part | membrane-bounded organelle | nucleus | organelle | cytoplasmic part | membrane-enclosed lumen | intracellular organelle lumen | non-membrane-bounded organelle | cytosol | cytoskeleton | intracellular part | intracellular | membrane | cytoskeletal part | protein complex