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QuickView for Metoprolol (compound)


PubChem
Name: Metoprolol
PubChem Compound ID: 11957594
Description: A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.
Molecular formula: C34H56N2O12
Molecular weight: 684.815 g/mol
Synonyms:
EU-0100728
DrugBank
Identification
Name: Metoprolol
Name (isomeric): DB00264
Drug Type: small molecule
Description: A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.
Synonyms:
Metoprolol succinate; Metoprolol Tartrate
Brand: Lopresor, Lopressor HCT, Lopressor, Prelis, Metroprolol, Selo-Zok, Toprol-XL, Selopral, Beloc, Betaloc, Lopresoretic, Toprol XL, Seloken, Toprol
Category: Sympatholytics, Adrenergic Agents, Antiarrhythmic Agents, Adrenergic beta-Antagonists, Anti-Arrhythmia Agents, Antihypertensive Agents
CAS number: 37350-58-6
Pharmacology
Indication: For the management of acute myocardial infarction, angina pectoris, heart failure and mild to moderate hypertension. May be used to treat supraventricular and tachyarrhythmias and as prophylaxis for migraine headaches.
Pharmacology: Metoprolol, a competitive, beta1-selective (cardioselective) adrenergic antagonist, is similar to atenolol in its moderate lipid solubility, lack of intrinsic sympathomimetic activity (ISA), and weak membrane stabilizing activity (MSA).
Mechanism of Action: Metoprolol competes with adrenergic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart. Beta(1)-receptor blockade results in a decrease in heart rate, cardiac output, and blood pressure.
Absorption: Rapid and complete, 50%
Protein binding: 12%
Biotransformation: Primarily hepatic
Route of elimination: Less than 5% of an oral dose of metoprolol is recovered unchanged in the urine; the rest is excreted by the kidneys as metabolites that appear to have no beta-blocking activity.
Half Life: 3-7 hours
Toxicity: LD50=5500 mg/kg (orally in rats), toxic effects include bradycardia, hypotension, bronchospasm, and cardiac failure. LD50=2090 mg/kg (orally in mice)
Affected organisms: Humans and other mammals
Interactions
Food interaction:
Avoid alcohol.
Avoid natural licorice.
Take with food.
Drug interaction:
IbuprofenRisk of inhibition of renal prostaglandins
TerbinafineTerbinafine may reduce the metabolism and clearance of Metoprolol. Consider alternate therapy or monitor for therapeutic/adverse effects of Metoprolol if Terbinafine is initiated, discontinued or dose changed.
ProcaterolAntagonism
InsulinThe beta-blocker, metoprolol, may decrease symptoms of hypoglycemia.
HydralazineIncreased effect of both drugs
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