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QuickView for Mephenytoin (compound)


PubChem
Name: Mephenytoin
PubChem Compound ID: 107921
Description: An anticonvulsant effective in tonic-clonic epilepsy (EPILEPSY, TONIC-CLONIC). It may cause blood dyscrasias.
Molecular formula: C12H14N2O2
Molecular weight: 218.252 g/mol
Synonyms:
Mephenytoin, D-; 2,4-Imidazolidinedione, 5-ethyl-3-methyl-5-phenyl-, (S)-; 70989-04-7; ZINC00896648; (5S)-5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione
DrugBank
Identification
Name: Mephenytoin
Name (isomeric): DB00532
Drug Type: small molecule
Description: An anticonvulsant effective in tonic-clonic epilepsy (EPILEPSY, TONIC-CLONIC). It may cause blood dyscrasias.
Synonyms:
Mephentoin; Methylphenetoin; Methyl Hydantoin
Brand: Metydan, Sedantoinal, Methoin, Phenantoin, Triantoin, Gerot-Epilan, Insulton, Sacerno, Sedantional, Epiazin, Mesdontoin, Sedantoin, Mesontoin
Category: Anticonvulsants
CAS number: 50-12-4
Pharmacology
Indication: For the treatment of refractory partial epilepsy.
Pharmacology:
Mephenytoin is an antiepileptic drug which can be useful in the treatment of epilepsy. The primary site of action appears to be the motor cortex where spread of seizure activity is inhibited. Possibly by promoting sodium efflux from neurons, mephenytoin tends to stabilize the threshold against hyperexcitability caused by excessive stimulation or en...
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Mechanism of Action: The mechanism of action of mephenytoin is not definitely known, but extensive research strongly suggests that its main mechanism is to block frequency-, use- and voltage-dependent neuronal sodium channels, and therefore limit repetitive firing of action potentials.
Half Life: Approximately 7 hours
Affected organisms: Humans and other mammals
Interactions
Drug interaction:
FluvoxamineIncreases the effect of hydantoin
PhenylbutazoneThe NSAID, phenylbutazone, may increase the hydantoin effect of mephenytoin.
Ethinyl EstradiolThis product may cause a slight decrease of contraceptive effect
CapecitabineCapecitabine increases the effect of hydantoin
DisopyramideThe hydantoin decreases the effect of disopyramide
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