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QuickView for MYC (gene)


Gene Symbol:
MYC Homo sapiens Homo sapiens
Full name:
v-myc myelocytomatosis viral oncogene homolog (avian)
Synonyms:
myc proto-oncogene protein, myc-related translation/localization regulatory factor, MRTL, v-myc avian myelocytomatosis viral oncogene homolog, v-myc myelocytomatosis viral oncogene homolog (avian), proto-oncogene c-Myc, transcription factor p64, class E basic helix-loop-helix protein 39, c-Myc, bHLHe39, avian myelocytomatosis viral oncogene homolog
Genomic Location:
Chr 8: 128817498-128822856
Description:
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated w...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Canis lupus familiaris Gallus gallus Pan troglodytes Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Unknown transcription factor binding site geneset 3 Unknown transcription factor binding site geneset 6 Unknown transcription factor binding site geneset 8 NHLH1 binding site geneset 1 TCF3 binding site geneset 2 E2F1 binding site geneset 2 E2F1 binding site geneset 3 Unknown transcription factor binding site geneset 67 ZHX2 binding site geneset 1 E2F1 binding site geneset 4
miRNA binding sites
(Source: TargetScan):
miRNA binding sites
(Source: miRecords):
Cytogenetic Map:
chr 8
8q24.21


Transcripts Names
NM_002467
XM_001129520
Protein Names
A8WFE7
Q14026
P01107
P01106



GO Molecular Function

sequence-specific DNA binding | regulatory region DNA binding | transcription regulatory region DNA binding | repressing transcription factor binding | nucleic acid binding | protein complex binding | nucleic acid binding transcription factor activity | binding | structure-specific DNA binding | E-box binding | DNA binding | protein heterodimerization activity | organic cyclic compound binding | protein binding | double-stranded DNA binding | sequence-specific DNA binding transcription factor activity | transcription factor binding | regulatory region nucleic acid binding | protein dimerization activity | heterocyclic compound binding

GO Biological Process

RNA metabolic process | transcription from RNA polymerase II promoter | Notch signaling pathway | DNA-dependent transcription, initiation | response to radiation | regulation of biological process | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | negative regulation of cell division | regulation of cysteine-type endopeptidase activity | negative regulation of MAPK cascade | regulation of monocyte differentiation | detection of stimulus | release of cytochrome c from mitochondria | intracellular signal transduction | positive regulation of apoptotic process | morphogenesis of an epithelium | regulation of biosynthetic process | regulation of programmed cell death | establishment of localization | nucleic acid metabolic process | regulation of immune system process | fibroblast apoptotic process | regulation of biological quality | negative regulation of cellular process | positive regulation of developmental process | protein processing | regulation of DNA metabolic process | glucose metabolic process | positive regulation of epithelial cell proliferation | positive regulation of fibroblast proliferation | detection of mechanical stimulus involved in sensory perception | cellular macromolecule metabolic process | cellular component disassembly | response to drug | generation of precursor metabolites and energy | cellular chemical homeostasis | regulation of organelle organization | sensory perception of mechanical stimulus | cell-type specific apoptotic process | regulation of response to stimulus | negative regulation of stress-activated protein kinase signaling cascade | positive regulation of cellular biosynthetic process | cellular process | death | DNA catabolic process, endonucleolytic | localization | cellular homeostasis | epithelial tube morphogenesis | chromatin organization | negative regulation of signaling | apoptotic nuclear changes | regulation of kidney development | apoptotic DNA fragmentation | canonical Wnt receptor signaling pathway | anti-apoptosis | positive regulation of metanephric cap mesenchymal cell proliferation | detection of external stimulus | negative regulation of apoptotic process | branching involved in ureteric bud morphogenesis | negative regulation of survival gene product expression | regulation of cell cycle | response to growth factor stimulus | positive regulation of catalytic activity | regulation of myeloid cell differentiation | positive regulation of nitrogen compound metabolic process | regulation of nucleobase-containing compound metabolic process | cellular response to chemical stimulus | negative regulation of cellular metabolic process | tissue development | regulation of binding | regulation of myeloid leukocyte differentiation | regulation of cell differentiation | activation of pro-apoptotic gene products | regulation of lymphocyte apoptotic process | regulation of cellular process | cellular component organization or biogenesis | regulation of apoptotic process | regulation of metabolic process | catabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | regulation of response to stress | epithelium development | cellular aromatic compound metabolic process | cellular component organization | positive regulation of response to DNA damage stimulus | MAPK cascade | regulation of survival gene product expression | regulation of cell division | response to UV | response to stimulus | negative regulation of cell communication | nucleic acid binding transcription factor activity | regulation of metanephric cap mesenchymal cell proliferation | response to chemical stimulus | transport | positive regulation of peptidase activity | cellular response to light stimulus | response to stress | regulation of macromolecule biosynthetic process | regulation of cell proliferation | positive regulation of nucleobase-containing compound metabolic process | tube morphogenesis | positive regulation of cysteine-type endopeptidase activity | regulation of anatomical structure morphogenesis | execution phase of apoptosis | programmed cell death | macromolecule biosynthetic process | cellular component disassembly involved in execution phase of apoptosis | cellular nitrogen compound metabolic process | nucleic acid phosphodiester bond hydrolysis | apoptotic mitochondrial changes | negative regulation of metabolic process | cellular biosynthetic process | cellular catabolic process | embryo development | mitochondrion organization | metal ion homeostasis | regulation of cellular response to stress | detection of abiotic stimulus | apoptotic process | response to light stimulus | system development | nitrogen compound metabolic process | regulation of signal transduction | ureteric bud development | Wnt receptor signaling pathway | regulation of stress-activated protein kinase signaling cascade | multicellular organismal development | positive regulation of RNA metabolic process | regulation of peptidase activity | negative regulation of G2 phase of mitotic cell cycle | regulation of MAPK cascade | negative regulation of RNA metabolic process | cell cycle process | positive regulation of multicellular organismal process | response to DNA damage stimulus | regulation of telomere maintenance | B cell apoptotic process | intracellular protein kinase cascade | regulation of catalytic activity | response to abiotic stimulus | regulation of gene expression | cellular response to stress | neurological system process | cell cycle | positive regulation of cellular metabolic process | regulation of multicellular organismal development | cellular ion homeostasis | cellular response to radiation | cellular component disassembly at cellular level | organ morphogenesis | regulation of macromolecule metabolic process | negative regulation of myeloid cell differentiation | regulation of nitrogen compound metabolic process | single-organism process | enzyme linked receptor protein signaling pathway | monosaccharide metabolic process | regulation of cysteine-type endopeptidase activity involved in apoptotic process | negative regulation of nitrogen compound metabolic process | regulation of transcription from RNA polymerase II promoter | pigmentation | negative regulation of binding | positive regulation of hydrolase activity | cellular response to abiotic stimulus | gas transport | chromatin modification | biological regulation | biosynthetic process | regulation of metanephros development | regulation of primary metabolic process | middle ear morphogenesis | positive regulation of endopeptidase activity | negative regulation of stress-activated MAPK cascade | positive regulation of B cell apoptotic process | carbohydrate metabolic process | positive regulation of macromolecule metabolic process | protein maturation | positive regulation of leukocyte apoptotic process | response to gamma radiation | cation homeostasis | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | positive regulation of biological process | cellular response to UV | sensory organ development | regulation of B cell apoptotic process | regulation of cellular macromolecule biosynthetic process | negative regulation of response to stimulus | oxygen transport | cellular response to drug | negative regulation of developmental process | negative regulation of nucleobase-containing compound metabolic process | cellular cation homeostasis | cell communication | negative regulation of protein binding | regulation of cellular metabolic process | chromatin remodeling | transmembrane receptor protein serine/threonine kinase signaling pathway | skeletal system morphogenesis | positive regulation of DNA biosynthetic process | sensory perception of sound | system process | positive regulation of biosynthetic process | homeostatic process | positive regulation of cell proliferation | iron ion homeostasis | regulation of RNA metabolic process | apoptotic signaling pathway | embryonic morphogenesis | regulation of mitotic cell cycle | positive regulation of molecular function | embryonic organ morphogenesis | cellular component organization at cellular level | ureteric bud morphogenesis | protein metabolic process | regulation of fibroblast proliferation | sequence-specific DNA binding transcription factor activity | response to organic substance | tissue morphogenesis | cell cycle arrest | branching morphogenesis of a tube | regulation of cellular biosynthetic process | negative regulation of macromolecule biosynthetic process | DNA metabolic process | response to mechanical stimulus | regulation of organ morphogenesis | detection of stimulus involved in sensory perception | regulation of intracellular protein kinase cascade | negative regulation of intracellular protein kinase cascade | cellular macromolecule catabolic process | anatomical structure development | regulation of multicellular organismal process | cell surface receptor signaling pathway | metabolic process | primary metabolic process | activation of cysteine-type endopeptidase activity involved in apoptotic process | regulation of homeostatic process | regulation of RNA biosynthetic process | hexose metabolic process | oxidation-reduction process | negative regulation of transcription, DNA-dependent | negative regulation of programmed cell death | embryonic organ development | ear development | chemical homeostasis | positive regulation of cell death | macromolecule catabolic process | regulation of response to DNA damage stimulus | cellular response to stimulus | nucleobase-containing compound metabolic process | organic substance metabolic process | regulation of hydrolase activity | cell death | negative regulation of biosynthetic process | regulation of interphase of mitotic cell cycle | negative regulation of gene expression | regulation of leukocyte apoptotic process | organ development | gene expression | positive regulation of programmed cell death | ion homeostasis | leukocyte apoptotic process | regulation of chromosome organization | response to alkaloid | negative regulation of biological process | detection of mechanical stimulus | cellular iron ion homeostasis | transcription initiation from RNA polymerase II promoter | transcription, DNA-dependent | positive regulation of lymphocyte apoptotic process | morphogenesis of a branching epithelium | transforming growth factor beta receptor signaling pathway | anatomical structure formation involved in morphogenesis | lymphocyte apoptotic process | negative regulation of cell cycle | detection of mechanical stimulus involved in sensory perception of sound | sensory perception | regulation of stress-activated MAPK cascade | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | signaling | regulation of transcription, DNA-dependent | regulation of protein binding | negative regulation of macromolecule metabolic process | energy reserve metabolic process | regulation of molecular function | regulation of epithelial cell proliferation | negative regulation of fibroblast proliferation | cellular component organization or biogenesis at cellular level | morphogenesis of a branching structure | anatomical structure morphogenesis | regulation of endopeptidase activity | cellular macromolecule biosynthetic process | positive regulation of response to stimulus | negative regulation of monocyte differentiation | regulation of developmental process | positive regulation of DNA metabolic process | energy derivation by oxidation of organic compounds | DNA catabolic process | regulation of mesenchymal cell proliferation | developmental process | response to external stimulus | organelle organization | regulation of DNA biosynthetic process | regulation of G2 phase of mitotic cell cycle | negative regulation of cellular biosynthetic process | positive regulation of cellular process | negative regulation of transcription from RNA polymerase II promoter | tube development | positive regulation of transcription, DNA-dependent | negative regulation of cell proliferation | positive regulation of mesenchymal cell proliferation | positive regulation of kidney development | cellular metal ion homeostasis | single-multicellular organism process | single organism signaling | positive regulation of transcription from RNA polymerase II promoter | heterocycle metabolic process | negative regulation of cellular macromolecule biosynthetic process | positive regulation of metabolic process | chromosome organization | regulation of execution phase of apoptosis | skeletal system development | cellular metabolic process | negative regulation of cell cycle process | regulation of cell death | negative regulation of cell death | ear morphogenesis | negative regulation of myeloid leukocyte differentiation | activation of cysteine-type endopeptidase activity | negative regulation of cell differentiation | regulation of cellular component organization | response to ionizing radiation | signal transduction | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | neuron projection | cell | nuclear lumen | nucleolus | intracellular non-membrane-bounded organelle | cytoplasm | spindle | intracellular organelle | nuclear body | macromolecular complex | cell projection | nuclear part | nucleoplasm | organelle part | intracellular organelle part | organelle lumen | microtubule cytoskeleton | nucleoplasm part | cell part | membrane-bounded organelle | nucleus | organelle | axon | membrane-enclosed lumen | intracellular organelle lumen | non-membrane-bounded organelle | cytoskeleton | intracellular part | intracellular | cytoskeletal part | protein complex