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QuickView for MDM2 (gene)


Gene Symbol:
MDM2 Homo sapiens Homo sapiens
Full name:
Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
Synonyms:
hdm2, HDM2 transcript variant MYO-1, HDM2 transcript variant MYO-18, HDM2 transcript variant MYO-20, HDM2 transcript variant MYO-24, HDM2 transcript variant MYO-25, HDM2 transcript variant MYO-26, HDM2 transcript variant MYO-32, HDM2 transcript variant MYO-4, HDMX, ACTFS, double minute 2, human homolog of; p53-binding protein, E3 ubiquitin-protein ligase Mdm2, MGC5370, MGC71221, mouse double minute 2 homolog, MDM2 variant FB28, MDM2 variant FB30, Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse), Mdm2, transformed 3T3 cell double minute 2, p53 binding protein, p53-binding protein MDM2, OTTHUMP00000183495, oncoprotein Mdm2, ubiquitin-protein ligase E3 Mdm2
Genomic Location:
Chr 12: 67488247-67520481
Description:
This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor supp...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Gallus gallus Canis lupus familiaris Bos taurus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 12
12q14.3-q15





GO Molecular Function

cation binding | enzyme binding | acid-amino acid ligase activity | binding | catalytic activity | ligase activity, forming carbon-nitrogen bonds | small conjugating protein ligase activity | p53 binding | identical protein binding | scaffold protein binding | ion binding | protein binding | zinc ion binding | ligase activity | ubiquitin-protein ligase activity | transition metal ion binding | metal ion binding

GO Biological Process

positive regulation of cellular catabolic process | regulation of biological process | regulation of cell cycle process | cellular response to decreased oxygen levels | intracellular signal transduction | proteolysis | regulation of biosynthetic process | regulation of programmed cell death | signal transduction involved in G1/S transition checkpoint | peptidyl-amino acid modification | establishment of localization | regulation of biological quality | negative regulation of cellular process | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | cell cycle phase | cellular macromolecule metabolic process | positive regulation of protein catabolic process | DNA integrity checkpoint | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | regulation of G1/S transition of mitotic cell cycle | response to antibiotic | multicellular organismal signaling | regulation of response to stimulus | cellular process | localization | proteolysis involved in cellular protein catabolic process | regulation of DNA damage response, signal transduction by p53 class mediator | negative regulation of signaling | synaptic transmission | macromolecule localization | negative regulation of apoptotic process | response to hypoxia | macromolecular complex subunit organization | regulation of proteolysis | regulation of cell cycle | response to growth factor stimulus | regulation of nucleobase-containing compound metabolic process | negative regulation of cell cycle arrest | cellular response to chemical stimulus | G1/S transition checkpoint | negative regulation of cellular metabolic process | interspecies interaction between organisms | regulation of cellular process | cellular component organization or biogenesis | regulation of apoptotic process | regulation of metabolic process | catabolic process | epidermal growth factor receptor signaling pathway | positive regulation of cellular protein metabolic process | regulation of response to stress | positive regulation of catabolic process | cellular component organization | modification-dependent macromolecule catabolic process | G1 phase | response to stimulus | negative regulation of cell communication | response to chemical stimulus | cellular response to fibroblast growth factor stimulus | mitotic cell cycle G1/S transition checkpoint | positive regulation of protein metabolic process | protein complex assembly | cellular response to hypoxia | response to stress | regulation of macromolecule biosynthetic process | posttranscriptional regulation of gene expression | regulation of cell proliferation | protein localization to nucleus | acid-amino acid ligase activity | protein destabilization | phosphatidylinositol-mediated signaling | reproduction | cellular protein catabolic process | cellular localization | positive regulation of proteolysis | ERBB signaling pathway | response to endogenous stimulus | negative regulation of metabolic process | cellular component assembly | protein modification process | protein complex subunit organization | response to decreased oxygen levels | cellular catabolic process | macromolecule modification | cell-cell signaling | catalytic activity | regulation of cellular response to stress | ligase activity, forming carbon-nitrogen bonds | response to oxygen levels | reproductive process | regulation of signal transduction | DNA damage response, signal transduction by p53 class mediator | regulation of protein stability | small conjugating protein ligase activity | negative regulation of RNA metabolic process | cell cycle process | response to DNA damage stimulus | fibroblast growth factor receptor signaling pathway | response to abiotic stimulus | interaction with host | positive regulation of cell cycle | positive regulation of mitotic cell cycle | signal transduction in response to DNA damage | regulation of gene expression | interphase | cellular component biogenesis | cellular response to stress | neurological system process | cell cycle | protein catabolic process | regulation of cell cycle arrest | positive regulation of cellular metabolic process | regulation of macromolecule metabolic process | cellular response to oxygen levels | protein complex biogenesis | regulation of nitrogen compound metabolic process | single-organism process | protein modification by small protein conjugation | enzyme linked receptor protein signaling pathway | negative regulation of nitrogen compound metabolic process | regulation of transcription from RNA polymerase II promoter | multi-organism process | protein localization to organelle | biological regulation | regulation of primary metabolic process | regulation of cellular protein metabolic process | signal transduction involved in mitotic cell cycle G1/S checkpoint | interphase of mitotic cell cycle | inositol lipid-mediated signaling | positive regulation of macromolecule metabolic process | signal transduction involved in cell cycle checkpoint | regulation of cellular catabolic process | positive regulation of biological process | regulation of cellular macromolecule biosynthetic process | negative regulation of response to stimulus | mitotic cell cycle G1/S transition DNA damage checkpoint | negative regulation of nucleobase-containing compound metabolic process | cell communication | regulation of cellular metabolic process | signal transduction involved in DNA integrity checkpoint | regulation of protein metabolic process | system process | positive regulation of cell proliferation | protein ubiquitination involved in ubiquitin-dependent protein catabolic process | regulation of RNA metabolic process | viral reproduction | regulation of mitotic cell cycle | regulation of catabolic process | regulation of proteasomal ubiquitin-dependent protein catabolic process | positive regulation of cell cycle arrest | macromolecular complex assembly | protein metabolic process | response to organic substance | nerve growth factor receptor signaling pathway | protein ubiquitination | regulation of cellular biosynthetic process | negative regulation of macromolecule biosynthetic process | negative regulation of DNA damage response, signal transduction by p53 class mediator | cellular macromolecule catabolic process | mitotic cell cycle | cell surface receptor signaling pathway | ligase activity | metabolic process | primary metabolic process | ubiquitin-protein ligase activity | regulation of protein catabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-dependent | negative regulation of programmed cell death | regulation of proteasomal protein catabolic process | cellular protein localization | peptidyl-lysine modification | macromolecule catabolic process | regulation of response to DNA damage stimulus | cellular response to stimulus | negative regulation of biosynthetic process | regulation of interphase of mitotic cell cycle | negative regulation of gene expression | cellular response to endogenous stimulus | signal transduction involved in mitotic cell cycle checkpoint | protein modification by small protein conjugation or removal | negative regulation of biological process | establishment of protein localization | ubiquitin-dependent protein catabolic process | viral reproductive process | regulation of cell communication | negative regulation of signal transduction | signaling | regulation of transcription, DNA-dependent | negative regulation of macromolecule metabolic process | protein localization | cellular protein metabolic process | cellular macromolecule localization | signal transduction involved in DNA damage checkpoint | traversing start control point of mitotic cell cycle | positive regulation of cell cycle process | multi-organism reproductive process | cellular protein modification process | negative regulation of cellular biosynthetic process | positive regulation of cellular process | negative regulation of transcription from RNA polymerase II promoter | virus-host interaction | response to fibroblast growth factor stimulus | G1 phase of mitotic cell cycle | single-multicellular organism process | single organism signaling | transmission of nerve impulse | signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint | symbiosis, encompassing mutualism through parasitism | negative regulation of cellular macromolecule biosynthetic process | transmembrane receptor protein tyrosine kinase signaling pathway | negative regulation of response to DNA damage stimulus | positive regulation of metabolic process | mitotic cell cycle checkpoint | cellular metabolic process | negative regulation of cell cycle process | cellular response to organic substance | regulation of cell death | modification-dependent protein catabolic process | DNA damage checkpoint | cell cycle checkpoint | signal transduction by p53 class mediator | negative regulation of cell death | signal transduction | regulation of signaling | cellular response to growth factor stimulus | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | endocytic vesicle membrane | organelle membrane | cytoplasmic vesicle | cell | nuclear lumen | nucleolus | intracellular non-membrane-bounded organelle | cytoplasm | intracellular organelle | nuclear body | macromolecular complex | endomembrane system | nuclear part | nucleoplasm | plasma membrane | organelle part | intracellular organelle part | organelle lumen | vesicle | nucleoplasm part | cell part | membrane-bounded organelle | nucleus | organelle | vesicle membrane | cell periphery | cytoplasmic part | membrane-enclosed lumen | cytoplasmic membrane-bounded vesicle | intracellular organelle lumen | cytoplasmic vesicle part | membrane-bounded vesicle | non-membrane-bounded organelle | cytosol | intracellular part | endocytic vesicle | intracellular | membrane | cytoplasmic vesicle membrane | protein complex