Clear Search sequence regions
Bookmark Forward Export SNPs

QuickView for LIF (gene)


Gene Symbol:
LIF Homo sapiens Homo sapiens
Full name:
leukemia inhibitory factor
Synonyms:
melanoma-derived LPL inhibitor, MLPLI, cholinergic differentiation factor, CDF, DIA, differentiation inhibitory activity, differentiation stimulating factor, differentiation-inducing factor, D factor, D-FACTOR, differentiation-stimulating factor, human interleukin in DA cells, HILDA, hepatocyte-stimulating factor III, leukemia inhibitory factor, leukemia inhibitory factor (cholinergic differentiation factor)
Genomic Location:
Chr 22: 28966441-28972748
Description:
The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role i...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Canis lupus familiaris Gallus gallus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
MEF2A binding site geneset 1 IRF1 binding site geneset 1 IRF2 binding site geneset 1 Unknown transcription factor binding site geneset 12 PBX1 binding site geneset 1 CUTL1 binding site geneset 2 PBX1 binding site geneset 2 POU3F1 binding site geneset 1 Unknown transcription factor binding site geneset 27 POU2F1 binding site geneset 7
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 22
22q12.2


Transcripts Names
NM_002309
NM_001257135
Protein Names
B5MC23
B2RCW7
P15018
Q52LZ2



GO Molecular Function

receptor binding | cytokine receptor binding | leukemia inhibitory factor receptor binding | binding | protein binding | growth factor activity | cytokine activity

GO Biological Process

regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis | regulation of ERK1 and ERK2 cascade | regulation of epithelial cell differentiation involved in kidney development | regulation of biological process | serine phosphorylation of STAT protein | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | negative regulation of MAPK cascade | negative regulation of reproductive process | positive regulation of cellular component organization | regulation of cell morphogenesis | regulation of neurogenesis | developmental process involved in reproduction | regulation of cellular localization | intracellular signal transduction | regulation of cell development | regulation of localization | regulation of biosynthetic process | positive regulation of cell communication | positive regulation of peptidyl-tyrosine phosphorylation | peptidyl-amino acid modification | eye development | regulation of meiotic cell cycle | regulation of immune system process | negative regulation of cellular process | positive regulation of developmental process | cell differentiation | JAK-STAT cascade | respiratory tube development | maternal placenta development | cellular macromolecule metabolic process | nervous system development | neurogenesis | positive regulation of phosphate metabolic process | regulation of protein modification process | peptidyl-tyrosine phosphorylation | regulation of peptide hormone secretion | generation of neurons | regulation of response to stimulus | positive regulation of cellular biosynthetic process | cellular process | tissue remodeling | negative regulation of signaling | positive regulation of peptidyl-serine phosphorylation | neuron development | regulation of kidney development | leukemia inhibitory factor signaling pathway | female pregnancy | multicellular organismal reproductive process | stem cell maintenance | negative regulation of secretion | regulation of cell cycle | regulation of tyrosine phosphorylation of STAT protein | regulation of myeloid cell differentiation | positive regulation of nitrogen compound metabolic process | regulation of neuron projection development | regulation of nucleobase-containing compound metabolic process | negative regulation of hormone secretion | tissue development | regulation of myeloid leukocyte differentiation | regulation of cell differentiation | regulation of system process | muscle structure development | regeneration | regulation of angiogenesis | regulation of cellular process | regulation of metabolic process | gliogenesis | regulation of nephron tubule epithelial cell differentiation | transdifferentiation | positive regulation of cellular protein metabolic process | regulation of peptide secretion | muscle organ morphogenesis | regulation of vasculature development | response to stimulus | negative regulation of cell communication | vasculature development | lung lobe morphogenesis | positive regulation of tyrosine phosphorylation of Stat3 protein | respiratory system development | regulation of peptidyl-tyrosine phosphorylation | blood vessel remodeling | positive regulation of protein metabolic process | positive regulation of peptidyl-serine phosphorylation of STAT protein | regulation of macromolecule biosynthetic process | positive regulation of JAK-STAT cascade | trophoblast giant cell differentiation | regulation of cell proliferation | positive regulation of nucleobase-containing compound metabolic process | negative regulation of angiogenesis | regulation of anatomical structure morphogenesis | regulation of epithelial cell differentiation | reproduction | cardiovascular system development | positive regulation of hormone secretion | negative regulation of transport | positive regulation of gliogenesis | protein modification process | regulation of peptide transport | embryo development | macromolecule modification | negative regulation of ERK1 and ERK2 cascade | positive regulation of corticotropin secretion | embryonic placenta development | positive regulation of macrophage differentiation | positive regulation of peptide secretion | lung alveolus development | system development | reproductive process | regulation of signal transduction | positive regulation of neuron projection development | multicellular organismal development | positive regulation of RNA metabolic process | regulation of MAPK cascade | phosphorus metabolic process | negative regulation of meiosis | intracellular protein kinase cascade | regulation of phosphorylation | regulation of hormone secretion | regulation of metanephric nephron tubule epithelial cell differentiation | regulation of neuron differentiation | regulation of gene expression | positive regulation of secretion | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of multicellular organismal development | organ morphogenesis | regulation of macromolecule metabolic process | tyrosine phosphorylation of Stat3 protein | regulation of nitrogen compound metabolic process | single-organism process | enzyme linked receptor protein signaling pathway | positive regulation of cell projection organization | positive regulation of intracellular protein kinase cascade | regulation of transcription from RNA polymerase II promoter | multi-organism process | positive regulation of cell differentiation | positive regulation of tyrosine phosphorylation of Stat1 protein | positive regulation of myeloid cell differentiation | peptidyl-tyrosine modification | stem cell differentiation | biological regulation | cell differentiation involved in embryonic placenta development | regulation of metanephros development | regulation of primary metabolic process | regulation of cellular protein metabolic process | glial cell differentiation | phosphorylation | positive regulation of macromolecule metabolic process | protein phosphorylation | positive regulation of biological process | phosphate-containing compound metabolic process | sensory organ development | regulation of cellular macromolecule biosynthetic process | negative regulation of response to stimulus | negative regulation of developmental process | positive regulation of phosphorus metabolic process | chordate embryonic development | cell communication | regulation of cellular metabolic process | positive regulation of tyrosine phosphorylation of STAT protein | astrocyte differentiation | regulation of endocrine process | regulation of protein metabolic process | positive regulation of signal transduction | positive regulation of biosynthetic process | positive regulation of cell proliferation | regulation of protein phosphorylation | embryo development ending in birth or egg hatching | lung vasculature development | regulation of RNA metabolic process | positive regulation of transport | positive regulation of peptide hormone secretion | decidualization | neuron differentiation | multicellular organism reproduction | maternal process involved in female pregnancy | regulation of cell morphogenesis involved in differentiation | protein metabolic process | positive regulation of protein modification process | regulation of meiosis | cellular developmental process | retina development in camera-type eye | regulation of cellular biosynthetic process | regulation of JAK-STAT cascade | regulation of organ morphogenesis | regulation of intracellular protein kinase cascade | negative regulation of intracellular protein kinase cascade | anatomical structure development | regulation of multicellular organismal process | cell surface receptor signaling pathway | positive regulation of neurogenesis | metabolic process | positive regulation of cell development | primary metabolic process | regulation of RNA biosynthetic process | embryonic organ development | positive regulation of glial cell differentiation | regulation of secretion | immune response | cellular response to stimulus | single organism reproductive process | organ development | positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis | regulation of phosphate metabolic process | positive regulation of astrocyte differentiation | negative regulation of biological process | positive regulation of MAPK cascade | lung development | stem cell development | camera-type eye development | regulation of peptidyl-serine phosphorylation | anatomical structure formation involved in morphogenesis | regulation of glial cell differentiation | regulation of cell communication | regulation of gliogenesis | regulation of macrophage differentiation | negative regulation of signal transduction | regulation of corticotropin secretion | signaling | regulation of transcription, DNA-dependent | regulation of peptidyl-serine phosphorylation of STAT protein | cell development | positive regulation of phosphorylation | cellular protein metabolic process | anatomical structure morphogenesis | positive regulation of response to stimulus | regulation of nervous system development | tyrosine phosphorylation of STAT protein | regulation of developmental process | regulation of reproductive process | developmental process | multi-organism reproductive process | peptidyl-serine phosphorylation | cellular protein modification process | regulation of tyrosine phosphorylation of Stat1 protein | positive regulation of cellular process | tube development | regulation of transport | positive regulation of transcription, DNA-dependent | negative regulation of cell proliferation | peptidyl-serine modification | lung morphogenesis | single-multicellular organism process | single organism signaling | positive regulation of transcription from RNA polymerase II promoter | embryo implantation | central nervous system development | in utero embryonic development | positive regulation of metabolic process | regulation of tyrosine phosphorylation of Stat3 protein | regulation of cell projection organization | positive regulation of myeloid leukocyte differentiation | immune system process | lung lobe development | cellular metabolic process | negative regulation of cell cycle process | placenta development | regulation of astrocyte differentiation | positive regulation of cell morphogenesis involved in differentiation | spongiotrophoblast layer development | spongiotrophoblast differentiation | circulatory system development | negative regulation of cell differentiation | regulation of cellular component organization | muscle organ development | positive regulation of signaling | signal transduction | regulation of signaling | organ regeneration | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

cell | cytoplasm | cell part | extracellular region | extracellular space | extracellular region part | intracellular part | intracellular