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QuickView for LEP (gene)


Gene Symbol:
LEP Homo sapiens Homo sapiens
Full name:
leptin
Synonyms:
OB, obese protein, obese, mouse, homolog of, obesity factor, OBS, leptin, leptin (murine obesity homolog), leptin (obesity homolog, mouse), FLJ94114
Genomic Location:
Chr 7: 127668567-127684917
Description:
This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also h...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 7
7q31.3


Transcripts Names
NM_000230
Protein Names
Q56A88
A4D0Y8
O15158
P41159



GO Molecular Function

hormone receptor binding | receptor binding | hormone activity | binding | peptide hormone receptor binding | protein binding | growth factor activity

GO Biological Process

small molecule biosynthetic process | response to extracellular stimulus | adipose tissue development | regulation of biological process | alditol biosynthetic process | negative regulation of multicellular organismal process | regulation of intracellular protein transport | response to nutrient levels | response to cytokine stimulus | cell motility | developmental process involved in reproduction | regulation of cellular localization | negative regulation of peptide secretion | intracellular signal transduction | regulation of cholesterol transport | regulation of localization | regulation of biosynthetic process | positive regulation of cell communication | monocarboxylic acid catabolic process | gonad development | regulation of carbohydrate metabolic process | regulation of programmed cell death | hormone secretion | positive regulation of peptidyl-tyrosine phosphorylation | female gonad development | peptidyl-amino acid modification | glycerol biosynthetic process | cellular response to external stimulus | establishment of localization | response to hormone stimulus | regulation of immune system process | regulation of biological quality | negative regulation of cellular process | positive regulation of developmental process | negative regulation of response to external stimulus | glucose metabolic process | bone development | cell differentiation | bone mineralization | JAK-STAT cascade | cellular macromolecule metabolic process | negative regulation of organic acid transport | nervous system development | cellular response to extracellular stimulus | positive regulation of transmembrane transport | generation of precursor metabolites and energy | neurogenesis | polyol metabolic process | positive regulation of phosphate metabolic process | regulation of protein modification process | peptidyl-tyrosine phosphorylation | regulation of peptide hormone secretion | generation of neurons | regulation of lipid transport | regulation of response to stimulus | sterol metabolic process | cellular process | secretion | peptide hormone secretion | negative regulation of glucagon secretion | negative regulation of response to extracellular stimulus | regulation of STAT protein import into nucleus | localization | neuron development | central nervous system neuron differentiation | reproductive system development | female pregnancy | regulation of digestive system process | multicellular organismal reproductive process | negative regulation of amino acid transport | negative regulation of apoptotic process | negative regulation of secretion | response to hypoxia | alcohol biosynthetic process | regulation of tyrosine phosphorylation of STAT protein | regulation of multicellular organism growth | regulation of myeloid cell differentiation | regulation of appetite | regulation of nucleobase-containing compound metabolic process | cellular response to chemical stimulus | negative regulation of hormone secretion | regulation of organic acid transport | establishment of localization in cell | negative regulation of cellular metabolic process | response to peptide hormone stimulus | tissue development | regulation of cell differentiation | gamete generation | regulation of system process | cellular response to retinoic acid | regulation of cellular process | small molecule catabolic process | regulation of apoptotic process | positive regulation of insulin receptor signaling pathway | leukocyte tethering or rolling | regulation of metabolic process | catabolic process | cellular carbohydrate biosynthetic process | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | negative regulation of appetite | cellular lipid metabolic process | development of primary sexual characteristics | regulation of peptide secretion | glycerol metabolic process | response to stimulus | oxoacid metabolic process | ovulation | female gamete generation | positive regulation of tyrosine phosphorylation of Stat3 protein | regulation of transmembrane transport | monocarboxylic acid metabolic process | response to chemical stimulus | regulation of peptidyl-tyrosine phosphorylation | transport | regulation of insulin secretion | positive regulation of protein metabolic process | cellular response to vitamin A | carboxylic acid catabolic process | response to stress | regulation of macromolecule biosynthetic process | positive regulation of JAK-STAT cascade | cellular response to vitamin | alcohol metabolic process | regulation of cell proliferation | ovulation cycle | regulation of response to external stimulus | circadian rhythm | development of primary female sexual characteristics | positive regulation of cell activation | reproduction | cellular localization | secretion by cell | fatty acid catabolic process | rhythmic process | regulation of response to extracellular stimulus | positive regulation of hormone secretion | negative regulation of transport | regulation of protein transport | blood circulation | response to endogenous stimulus | negative regulation of metabolic process | protein modification process | regulation of peptide transport | response to decreased oxygen levels | regulation of steroid biosynthetic process | cellular biosynthetic process | cellular catabolic process | ovulation from ovarian follicle | macromolecule modification | cell-cell signaling | regulation of steroid metabolic process | insulin secretion | regulation of intracellular transport | regulation of lipoprotein lipid oxidation | leukocyte migration | locomotion | central nervous system neuron development | cellular response to hormone stimulus | system development | cellular response to nutrient levels | response to oxygen levels | reproductive process | regulation of signal transduction | regulation of cartilage development | multicellular organismal development | cell migration | regulation of intestinal cholesterol absorption | regulation of MAPK cascade | phosphorus metabolic process | negative regulation of RNA metabolic process | positive regulation of multicellular organismal process | response to vitamin E | intracellular protein kinase cascade | lipid metabolic process | regulation of phosphorylation | regulation of hormone levels | regulation of hormone secretion | response to abiotic stimulus | regulation of gene expression | positive regulation of secretion | regulation of response to food | regulation of blood pressure | polyol biosynthetic process | regulation of amino acid transport | positive regulation of intracellular protein transport | positive regulation of cellular metabolic process | regulation of lipoprotein oxidation | positive regulation of protein phosphorylation | regulation of multicellular organismal development | positive regulation of luteinizing hormone secretion | regulation of macromolecule metabolic process | regulation of protein localization to nucleus | regulation of nitrogen compound metabolic process | single-organism process | monosaccharide metabolic process | small molecule metabolic process | cellular carbohydrate metabolic process | peptide transport | negative regulation of nitrogen compound metabolic process | cytokine-mediated signaling pathway | regulation of cellular carbohydrate metabolic process | positive regulation of intracellular protein kinase cascade | regulation of transcription from RNA polymerase II promoter | response to nutrient | multi-organism process | positive regulation of cell differentiation | positive regulation of myeloid cell differentiation | peptidyl-tyrosine modification | cellular response to L-ascorbic acid | carbohydrate biosynthetic process | cellular response to cytokine stimulus | biological regulation | cellular ketone metabolic process | biosynthetic process | regulation of primary metabolic process | cellular component movement | regulation of cellular protein metabolic process | eating behavior | negative regulation of peptide hormone secretion | regulation of amine transport | phosphorylation | response to vitamin A | carbohydrate metabolic process | positive regulation of follicle-stimulating hormone secretion | positive regulation of macromolecule metabolic process | leptin-mediated signaling pathway | protein phosphorylation | positive regulation of biological process | phosphate-containing compound metabolic process | positive regulation of cellular response to insulin stimulus | ovulation cycle process | regulation of cellular macromolecule biosynthetic process | negative regulation of response to stimulus | negative regulation of developmental process | positive regulation of phosphorus metabolic process | negative regulation of nucleobase-containing compound metabolic process | peptide secretion | regulation of response to nutrient levels | cell communication | regulation of cellular metabolic process | cellular lipid catabolic process | positive regulation of tyrosine phosphorylation of STAT protein | regulation of endocrine process | regulation of protein metabolic process | system process | positive regulation of signal transduction | positive regulation of cell proliferation | regulation of carbohydrate biosynthetic process | regulation of protein phosphorylation | anatomical structure maturation | organic acid catabolic process | regulation of RNA metabolic process | positive regulation of transport | response to retinoic acid | regulation of lipid biosynthetic process | ossification involved in bone maturation | carboxylic acid metabolic process | regulation of nucleocytoplasmic transport | bile acid metabolic process | neuron differentiation | multicellular organism reproduction | protein metabolic process | cellular response to nutrient | regulation of establishment of protein localization | negative regulation of response to food | positive regulation of protein modification process | regulation of growth | response to organic substance | regulation of protein import into nucleus | cellular developmental process | regulation of cellular biosynthetic process | negative regulation of macromolecule biosynthetic process | regulation of JAK-STAT cascade | adult feeding behavior | regulation of intracellular protein kinase cascade | response to leptin stimulus | response to insulin stimulus | anatomical structure development | regulation of multicellular organismal process | cell surface receptor signaling pathway | regulation of vasoconstriction | regulation of glucose metabolic process | leukocyte cell-cell adhesion | metabolic process | primary metabolic process | regulation of RNA biosynthetic process | circulatory system process | hexose metabolic process | developmental maturation | cholesterol metabolic process | oxidation-reduction process | negative regulation of transcription, DNA-dependent | negative regulation of programmed cell death | regulation of secretion | behavior | cell adhesion | negative regulation of amine transport | hormone transport | cellular response to stimulus | single organism reproductive process | lipid catabolic process | organic substance metabolic process | connective tissue development | response to vitamin | negative regulation of biosynthetic process | negative regulation of gene expression | organ development | positive regulation of ion transport | regulation of insulin receptor signaling pathway | regulation of cell activation | cellular response to endogenous stimulus | regulation of cellular response to insulin stimulus | regulation of phosphate metabolic process | biomineral tissue development | positive regulation of gonadotropin secretion | negative regulation of biological process | fatty acid metabolic process | response to L-ascorbic acid | alditol metabolic process | cell-cell adhesion | positive regulation of cytokine production | positive regulation of intracellular transport | positive regulation of MAPK cascade | positive regulation of protein transport | negative regulation of response to nutrient levels | negative regulation of cartilage development | adult behavior | bone maturation | steroid metabolic process | regulation of cell communication | positive regulation of developmental growth | signaling | feeding behavior | positive regulation of growth | regulation of transcription, DNA-dependent | negative regulation of macromolecule metabolic process | cell development | energy reserve metabolic process | regulation of developmental growth | single-organism behavior | organic acid metabolic process | positive regulation of phosphorylation | cellular protein metabolic process | regulation of follicle-stimulating hormone secretion | regulation of cytokine production | hormone metabolic process | positive regulation of response to stimulus | positive regulation of protein import into nucleus | regulation of glucagon secretion | reproductive structure development | regulation of cellular ketone metabolic process | tyrosine phosphorylation of STAT protein | regulation of developmental process | regulation of ion transport | energy derivation by oxidation of organic compounds | developmental process | response to external stimulus | localization of cell | regulation of sterol transport | multi-organism reproductive process | cellular protein modification process | negative regulation of cellular biosynthetic process | cellular extravasation | positive regulation of cellular process | negative regulation of transcription from RNA polymerase II promoter | regulation of transport | response to dietary excess | signal release | positive regulation of STAT protein import into nucleus | single-multicellular organism process | single organism signaling | regulation of gluconeogenesis | central nervous system development | negative regulation of cellular macromolecule biosynthetic process | regulation of lipid metabolic process | positive regulation of metabolic process | ossification | regulation of lipoprotein metabolic process | regulation of tyrosine phosphorylation of Stat3 protein | skeletal system development | immune system process | negative regulation of vasoconstriction | cellular metabolic process | placenta development | female sex differentiation | cellular response to organic substance | regulation of protein localization | sex differentiation | regulation of cell death | generation of a signal involved in cell-cell signaling | negative regulation of cell death | bone mineralization involved in bone maturation | biological adhesion | positive regulation of nucleocytoplasmic transport | sexual reproduction | regulation of luteinizing hormone secretion | positive regulation of signaling | signal transduction | cellular response to leptin stimulus | regulation of signaling | regulation of gonadotropin secretion | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

cell | cell part | extracellular region | extracellular space | extracellular region part | intracellular