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QuickView for KCNH2 (gene)


Gene Symbol:
KCNH2 Homo sapiens Homo sapiens
Full name:
potassium voltage-gated channel, subfamily H (eag-related), member 2
Synonyms:
potassium voltage-gated channel subfamily H member 2, potassium voltage-gated channel, subfamily H (eag-related), member 2, ERG1, ether-a-go-go-related gene potassium channel 1, ether-a-go-go-related potassium channel protein, ether-a-go-go-related protein 1, HERG, hERG-1, HERG1, H-ERG, LQT2, Kv11.1, voltage-gated potassium channel subunit Kv11.1, voltage-gated potassium channel, subfamily H, member 2, SQT1, eag homolog, eag-related protein 1
Genomic Location:
Chr 7: 150272982-150305947
Description:
This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq]
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster Danio rerio Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
TCF3 binding site geneset 1 TFAP4 binding site geneset 1 Unknown transcription factor binding site geneset 17 CUTL1 binding site geneset 5 JUN binding site geneset 3 TFAP4 binding site geneset 2 MYOD1 binding site geneset 2 JUN binding site geneset 5 NF1 binding site geneset 2 Unknown transcription factor binding site geneset 45
miRNA binding sites
(Source: miRecords):
Cytogenetic Map:
chr 7
7q36.1





GO Molecular Function

protein histidine kinase activity | phosphotransferase activity, nitrogenous group as acceptor | ligand-gated channel activity | voltage-gated ion channel activity | delayed rectifier potassium channel activity | passive transmembrane transporter activity | inward rectifier potassium channel activity | transmembrane transporter activity | ligand-gated ion channel activity | binding | catalytic activity | two-component sensor activity | cation transmembrane transporter activity | signaling receptor activity | transporter activity | ion transmembrane transporter activity | gated channel activity | substrate-specific transmembrane transporter activity | voltage-gated potassium channel activity | receptor activity | molecular transducer activity | protein binding | potassium channel activity | metal ion transmembrane transporter activity | voltage-gated cation channel activity | potassium ion transmembrane transporter activity | signal transducer activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | cation channel activity | substrate-specific transporter activity | inorganic cation transmembrane transporter activity | monovalent inorganic cation transmembrane transporter activity | voltage-gated channel activity | channel activity | kinase activity | ion channel activity | substrate-specific channel activity

GO Biological Process

regulation of biological process | protein histidine kinase activity | regulation of localization | phosphotransferase activity, nitrogenous group as acceptor | regulation of biosynthetic process | establishment of localization | regulation of biological quality | ligand-gated channel activity | cellular macromolecule metabolic process | cellular chemical homeostasis | voltage-gated ion channel activity | multicellular organismal signaling | cellular process | delayed rectifier potassium channel activity | localization | cellular homeostasis | passive transmembrane transporter activity | metal ion transport | synaptic transmission | macromolecular complex subunit organization | regulation of nucleobase-containing compound metabolic process | regulation of system process | regulation of cellular process | cellular component organization or biogenesis | regulation of metabolic process | inward rectifier potassium channel activity | transmembrane transporter activity | ligand-gated ion channel activity | cellular component organization | muscle contraction | response to stimulus | regulation of transmembrane transport | transport | protein complex assembly | signal transduction by phosphorylation | regulation of macromolecule biosynthetic process | regulation of heart rate | blood circulation | cellular component assembly | protein modification process | protein complex subunit organization | macromolecule modification | cell-cell signaling | catalytic activity | two-component sensor activity | regulation of membrane potential | phosphorus metabolic process | protein oligomerization | ion transmembrane transport | regulation of gene expression | cellular component biogenesis | neurological system process | cation transmembrane transporter activity | cellular ion homeostasis | monovalent inorganic cation transport | regulation of macromolecule metabolic process | protein complex biogenesis | signaling receptor activity | regulation of nitrogen compound metabolic process | single-organism process | transporter activity | cellular potassium ion transport | ion transmembrane transporter activity | potassium ion transport | gated channel activity | biological regulation | regulation of primary metabolic process | phosphorylation | substrate-specific transmembrane transporter activity | regulation of heart contraction | protein phosphorylation | phosphate-containing compound metabolic process | regulation of cellular macromolecule biosynthetic process | cell communication | regulation of cellular metabolic process | voltage-gated potassium channel activity | system process | homeostatic process | regulation of RNA metabolic process | potassium channel activity | macromolecular complex assembly | protein metabolic process | regulation of heart rate by cardiac conduction | regulation of cellular biosynthetic process | metal ion transmembrane transporter activity | regulation of multicellular organismal process | voltage-gated cation channel activity | potassium ion transmembrane transporter activity | signal transducer activity | metabolic process | transferase activity, transferring phosphorus-containing groups | primary metabolic process | regulation of RNA biosynthetic process | circulatory system process | phosphotransferase activity, alcohol group as acceptor | chemical homeostasis | cellular response to stimulus | protein kinase activity | two-component signal transduction system (phosphorelay) | transferase activity | ion homeostasis | regulation of ion transmembrane transport | cation channel activity | substrate-specific transporter activity | transmembrane transport | signaling | inorganic cation transmembrane transporter activity | regulation of transcription, DNA-dependent | monovalent inorganic cation transmembrane transporter activity | voltage-gated channel activity | cellular protein metabolic process | protein heterooligomerization | cation transport | channel activity | regulation of ion transport | kinase activity | cellular protein modification process | regulation of transport | potassium ion transmembrane transport | single-multicellular organism process | single organism signaling | transmission of nerve impulse | ion channel activity | ion transport | cellular metabolic process | substrate-specific channel activity | muscle system process | signal transduction | cardiac conduction | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

integral to membrane | intracellular membrane-bounded organelle | plasma membrane part | potassium channel complex | cell | intrinsic to membrane | cytoplasm | intracellular organelle | macromolecular complex | endomembrane system | nuclear part | plasma membrane | nuclear envelope | organelle part | intracellular organelle part | envelope | voltage-gated potassium channel complex | organelle envelope | membrane part | integral to plasma membrane | cell part | membrane-bounded organelle | nucleus | organelle | cell periphery | cation channel complex | ion channel complex | intracellular part | intracellular | membrane | protein complex | intrinsic to plasma membrane