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QuickView for Isotretinoin (compound)


PubChem
Name: Isotretinoin
PubChem Compound ID: 5282379
Description: A topical dermatologic agent that is used in the treatment of ACNE VULGARIS and several other skin diseases. The drug has teratogenic and other adverse effects.
Molecular formula: C20H28O2
Molecular weight: 300.435 g/mol
Synonyms:
BRN 1885770; EINECS 225-296-0; 4759-48-2; HSDB 3929; Isotretinoin [USAN:BAN:INN]; Retinoic acid, cis-; Isotretinoine [INN-French]; Ro-4-3780; Ro-43780; 13-cis-Vitamin A acid.
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DrugBank
Identification
Name: Isotretinoin
Name (isomeric): DB00982
Drug Type: small molecule
Description: A topical dermatologic agent that is used in the treatment of ACNE VULGARIS and several other skin diseases. The drug has teratogenic and other adverse effects.
Brand: Accutane Roche
Category: Keratolytic Agents, Antineoplastic Agents, Skin and Mucous Membrane Agents, Anti-acne Agents
CAS number: 4759-48-2
Pharmacology
Indication: For the treatment of severe recalcitrant nodular acne
Pharmacology:
Isotretinoin, a retinoid, is indicated in the treatment of severe recalcitrant nodular acne. Nodules are inflammatory lesions with a diameter of 5 mm or greater. The nodules may become suppurative or hemorrhagic. "Severe," by definition, means "many" as opposed to "few or several" nodules. Clinical improvement in nodular acne patients occurs in ass...
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Mechanism of Action: Isotretinoin noticeably reduces the production of sebum and shrinks the sebaceous glands. It stabilises keratinization and prevents comedones from forming. It also reduces inflammation in moderate-severe inflammatory acne. The exact mechanism of action is unknown, however it is known that it alters DNA transcription.
Protein binding: 99.9%
Route of elimination: Isotretinoin and its metabolites are further metabolized into conjugates, which are then excreted in urine and feces. The metabolites of isotretinoin and any conjugates are ultimately excreted in the feces and urine in relatively equal amounts (total of 65% to 83%).
Half Life: 17-50 hours
Clearance: 96 +/- 6.27 L/hr [severe recalcitrant nodular acne pediatric Patients, 12 to 15 Years]
Toxicity: Isotretinoin is teratogenic. It also causes mucocutaneous side effects suck as cheilitis, dry skin, and dry eyes.
Affected organisms: Humans and other mammals
Interactions
Food interaction:
Take with a full glass of water Do not take supplements containing Vitamin A.
Avoid alcohol.
Take with high-fat meal to increase absorption.
Drug interaction:
TetracyclineIncreased risk of intracranial hypertension
MinocyclineIncreased risk of intracranial hypertension
MethacyclineIncreased risk of intracranial hypertension
RolitetracyclineIncreased risk of intracranial hypertension
Vitamin AIsotretinoin increases the risk of vitamin A toxicity. Avoid vitamin A supplementation while taking isotretinoin.
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Targets