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PubChem
Name: Iron
PubChem Compound ID: 23925
Description: A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
Molecular formula: Fe
Molecular weight: 55.845 g/mol
Synonyms:
Fe(Ii) Ion; C00023; 73135-38-3; Fe(Iii) Atom; 14067-02-8; Carbonyl iron; Ancor en 80/150; PZh3M; 129048-51-7; EINECS 231-096-4.
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DrugBank
Identification
Name: Iron
Name (isomeric): DB01592
Drug Type: small molecule
Description: A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
Brand: Nephro-Fer, Feronate, Ferrousal, Ferro-Time, Feosol, Ircon, Siderol, Fer-In-Sol, Fergon, Ferretts, Hemocyte, Fe-40, Ferro-Caps, Yieronia, Feratab, Slow Fe, Mol-Iron, Feostat, Ed-In-Sol, Vitedyn-Slo
Category: Iron Supplement, Trace Elements, Antianemic Agents
CAS number: 7439-89-6
Pharmacology
Indication: Used in preventing and treating iron-deficiency anemia.
Pharmacology: The major activity of supplemental iron is in the prevention and treatment of iron deficiency anemia. Iron has putative immune-enhancing, anticarcinogenic and cognition-enhancing activities.
Mechanism of Action: Iron is necessary for the production of hemoglobin. Iron-deficiency can lead to decreased production of hemoglobin and a microcytic, hypochromic anemia.
Absorption: The efficiency of absorption depends on the salt form, the amount administered, the dosing regimen and the size of iron stores. Subjects with normal iron stores absorb 10% to 35% of an iron dose. Those who are iron deficient may absorb up to 95% of an iron dose.
Toxicity: Acute iron overdosage can be divided into four stages. In the first stage, which occurs up to six hours after ingestion, the principal symptoms are vomiting and diarrhea. Other symptoms include hypotension, tachycardia and CNS depression ranging from lethargy to coma. The second phase may occur at 6-24 hours after ingestion and is characterized by a temporary remission. In the third phase, gastrointestinal symptoms recur accompanied by shock, metabolic acidosis, coma, hepatic necrosis and jaundice, hypoglycemia, renal failure and pulmonary edema. The fourth phase may occur several weeks after ingestion and is characterized by gastrointestinal obstruction and liver damage. In a young child, 75 milligrams per kilogram is considered extremely dangerous. A dose of 30 milligrams per kilogram can lead to symptoms of toxicity. Estimates of a lethal dosage range from 180 milligrams per kilogram and upwards. A peak serum iron concentration of five micrograms or more per ml is associated with moderate to severe poisoning in many.
Affected organisms: Humans and other mammals
Interactions
Drug interaction:
ClodronateFormation of non-absorbable complexes
GemifloxacinFormation of non-absorbable complexes
TetracyclineFormation of non-absorbable complexes
OfloxacinFormation of non-absorbable complexes
Mycophenolate mofetilOral iron decreases the absorption of mycophenolate-mofetil
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