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QuickView for IL1RN (gene)


Gene Symbol:
IL1RN Homo sapiens Homo sapiens
Full name:
interleukin 1 receptor antagonist
Synonyms:
IRAP, interleukin 1 receptor antagonist, interleukin-1 receptor antagonist protein, intracellular IL-1 receptor antagonist type II, intracellular interleukin-1 receptor antagonist (icIL-1ra), ICIL-1RA, IL-1ra, IL-1ra3, IL-1RN, IL1 inhibitor, IL1F3, IL1RA, IL1RN (IL1F3), OTTHUMP00000203730, MGC10430, MVCD4, type II interleukin-1 receptor antagonist, DIRA
Genomic Location:
Chr 2: 113591941-113608064
Description:
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spannin...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
NFKB RELA binding site geneset 1 JUN binding site geneset 2 JUN binding site geneset 3 JUN binding site geneset 4 JUN binding site geneset 5 Unknown transcription factor binding site geneset 33 Unknown transcription factor binding site geneset 34 STAT5A binding site geneset 2 BACH1 binding site geneset 1 CEBPD binding site geneset 1
miRNA binding sites
(Source: TargetScan):
miRNA binding sites
(Source: miRecords):
Cytogenetic Map:
chr 2
2q14.2





GO Molecular Function

receptor antagonist activity | interleukin-1, Type II receptor binding | interleukin-1 Type II receptor antagonist activity | receptor inhibitor activity | receptor binding | cytokine receptor binding | interleukin-1 receptor antagonist activity | binding | protein binding | receptor regulator activity | interleukin-1 receptor binding | interleukin-1 Type I receptor antagonist activity | growth factor receptor binding | interleukin-1, Type I receptor binding

GO Biological Process

regulation of JUN kinase activity | negative regulation of receptor activity | regulation of biological process | regulation of cellular localization | regulation of localization | regulation of programmed cell death | hormone secretion | establishment of localization | response to hormone stimulus | regulation of biological quality | negative regulation of cellular process | regulation of MAP kinase activity | defense response | response to drug | receptor antagonist activity | extracellular regulation of signal transduction | positive regulation of phosphate metabolic process | regulation of protein modification process | regulation of response to stimulus | cellular process | secretion | peptide hormone secretion | localization | negative regulation of glutamate secretion | negative regulation of signaling | regulation of embryonic development | female pregnancy | positive regulation of protein kinase activity | regulation of response to cytokine stimulus | negative regulation of apoptotic process | negative regulation of secretion | interleukin-1 Type II receptor antagonist activity | positive regulation of catalytic activity | establishment of localization in cell | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | positive regulation of cellular protein metabolic process | regulation of response to stress | receptor inhibitor activity | response to stimulus | negative regulation of cell communication | response to chemical stimulus | transport | positive regulation of protein metabolic process | negative regulation of cell adhesion | response to stress | regulation of heterotypic cell-cell adhesion | regulation of anatomical structure morphogenesis | inflammatory response to antigenic stimulus | reproduction | cellular localization | secretion by cell | negative regulation of transport | interleukin-1 receptor antagonist activity | response to endogenous stimulus | positive regulation of protein serine/threonine kinase activity | regulation of cell adhesion | cell-cell signaling | insulin secretion | negative regulation of interleukin-1-mediated signaling pathway | regulation of cellular response to stress | reproductive process | regulation of signal transduction | regulation of stress-activated protein kinase signaling cascade | regulation of MAPK cascade | learning or memory | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | lipid metabolic process | regulation of phosphorylation | regulation of hormone levels | neurological system process | extracellular negative regulation of signal transduction | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of multicellular organismal development | regulation of macromolecule metabolic process | regulation of transferase activity | single-organism process | peptide transport | response to corticosteroid stimulus | multi-organism process | negative regulation of heterotypic cell-cell adhesion | acute-phase response | cognition | biological regulation | regulation of primary metabolic process | regulation of cellular protein metabolic process | positive regulation of macromolecule metabolic process | regulation of glutamate secretion | positive regulation of biological process | negative regulation of response to stimulus | positive regulation of phosphorus metabolic process | negative regulation of cell-cell adhesion | peptide secretion | cell communication | positive regulation of transferase activity | regulation of cellular metabolic process | regulation of protein kinase activity | inflammatory response | regulation of protein metabolic process | system process | regulation of protein phosphorylation | regulation of cytokine-mediated signaling pathway | positive regulation of molecular function | regulation of receptor activity | receptor regulator activity | chronic inflammatory response | positive regulation of protein modification process | response to organic substance | regulation of kinase activity | response to wounding | regulation of interleukin-1-mediated signaling pathway | regulation of intracellular protein kinase cascade | regulation of multicellular organismal process | negative regulation of response to cytokine stimulus | metabolic process | primary metabolic process | negative regulation of programmed cell death | regulation of cell-cell adhesion involved in gastrulation | regulation of secretion | behavior | immune response | hormone transport | interleukin-1 Type I receptor antagonist activity | positive regulation of kinase activity | regulation of phosphate metabolic process | negative regulation of biological process | regulation of JNK cascade | memory | regulation of stress-activated MAPK cascade | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | signaling | response to organic cyclic compound | single-organism behavior | regulation of molecular function | positive regulation of phosphorylation | positive regulation of MAP kinase activity | regulation of developmental process | multi-organism reproductive process | chronic inflammatory response to antigenic stimulus | positive regulation of cellular process | regulation of gastrulation | regulation of transport | regulation of cell-cell adhesion | signal release | response to organic nitrogen | single-multicellular organism process | single organism signaling | negative regulation of cytokine-mediated signaling pathway | positive regulation of JUN kinase activity | positive regulation of metabolic process | acute inflammatory response | immune system process | regulation of cell death | response to steroid hormone stimulus | generation of a signal involved in cell-cell signaling | negative regulation of cell death | regulation of signaling | response to glucocorticoid stimulus | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | microtubule organizing center | cell | intracellular non-membrane-bounded organelle | cytoplasm | intracellular organelle | centrosome | plasma membrane | organelle part | intracellular organelle part | vesicle | microtubule cytoskeleton | cell part | extracellular region | membrane-bounded organelle | nucleus | organelle | extracellular space | cell periphery | extracellular region part | cytoplasmic part | non-membrane-bounded organelle | cytoskeleton | intracellular part | intracellular | membrane | cytoskeletal part