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QuickView for IL1A (gene)


Gene Symbol:
IL1A Homo sapiens Homo sapiens
Full name:
interleukin 1, alpha
Synonyms:
interleukin 1, alpha, interleukin-1 alpha, IL-1 alpha, IL-1A, IL1, IL1-ALPHA, IL1A (IL1F1), IL1F1, hematopoietin-1, OTTHUMP00000203692, preinterleukin 1 alpha, pro-interleukin-1-alpha
Genomic Location:
Chr 2: 113247963-113259442
Description:
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 2
2q14


Transcripts Names
NM_000575
Protein Names
P01583
Q7RU02
Q53QF9



GO Molecular Function

cation binding | receptor binding | cytokine receptor binding | binding | ion binding | copper ion binding | protein binding | interleukin-1 receptor binding | cytokine activity | transition metal ion binding | growth factor receptor binding | metal ion binding

GO Biological Process

response to extracellular stimulus | regulation of ERK1 and ERK2 cascade | response to radiation | regulation of biological process | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | response to nutrient levels | response to cytokine stimulus | positive regulation of cellular component organization | response to lipopolysaccharide | regulation of cellular localization | regulation of localization | regulation of biosynthetic process | positive regulation of cell communication | regulation of programmed cell death | regulation of biological quality | negative regulation of cellular process | positive regulation of developmental process | response to metal ion | cell differentiation | defense response | regulation of organelle organization | positive regulation of protein secretion | regulation of response to stimulus | positive regulation of cellular biosynthetic process | cellular process | death | regulation of cytokine biosynthetic process | regulation of mitosis | anti-apoptosis | negative regulation of apoptotic process | response to hypoxia | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | positive regulation of cell division | regulation of nucleobase-containing compound metabolic process | cellular response to chemical stimulus | response to inorganic substance | tissue development | regulation of neurological system process | regulation of system process | regulation of sensory perception | regulation of angiogenesis | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | positive regulation of stress-activated MAPK cascade | regulation of response to stress | epithelium development | regulation of cell division | positive regulation of stress-activated protein kinase signaling cascade | regulation of vasculature development | response to stimulus | response to chemical stimulus | positive regulation of protein metabolic process | response to stress | regulation of macromolecule biosynthetic process | response to ozone | regulation of cell proliferation | positive regulation of nucleobase-containing compound metabolic process | positive regulation of lipid biosynthetic process | multicellular organismal homeostasis | regulation of anatomical structure morphogenesis | programmed cell death | positive regulation of cytokine biosynthetic process | positive regulation vascular endothelial growth factor production | positive regulation of cytokine secretion | response to temperature stimulus | response to molecule of bacterial origin | regulation of protein transport | response to endogenous stimulus | response to decreased oxygen levels | regulation of steroid biosynthetic process | regulation of steroid metabolic process | regulation of cellular response to stress | apoptotic process | regulation of interleukin-2 biosynthetic process | system development | response to oxygen levels | regulation of signal transduction | positive regulation of organelle organization | regulation of stress-activated protein kinase signaling cascade | multicellular organismal development | positive regulation of RNA metabolic process | regulation of MAPK cascade | positive regulation of multicellular organismal process | regulation of sensory perception of pain | wound healing | response to abiotic stimulus | positive regulation of nuclear division | positive regulation of cell cycle | regulation of gene expression | positive regulation of secretion | cellular response to stress | cellular response to heat | positive regulation of cellular metabolic process | regulation of multicellular organismal development | regulation of macromolecule metabolic process | regulation of interleukin-2 production | regulation of nitrogen compound metabolic process | single-organism process | positive regulation of JNK cascade | positive regulation of interleukin-2 biosynthetic process | cytokine-mediated signaling pathway | positive regulation of intracellular protein kinase cascade | regulation of transcription from RNA polymerase II promoter | response to nutrient | multi-organism process | acute-phase response | epidermal cell differentiation | positive regulation of steroid metabolic process | cellular response to cytokine stimulus | biological regulation | cell proliferation | regulation of primary metabolic process | positive regulation of macromolecule metabolic process | epidermis development | keratinization | keratinocyte differentiation | response to gamma radiation | positive regulation of biological process | regulation of cellular macromolecule biosynthetic process | response to bacterium | cell communication | regulation of cellular metabolic process | inflammatory response | regulation of protein metabolic process | positive regulation of signal transduction | positive regulation of biosynthetic process | homeostatic process | regulation of RNA metabolic process | positive regulation of transport | regulation of lipid biosynthetic process | fever generation | regulation of mitotic cell cycle | regulation of cytokine secretion | regulation of establishment of protein localization | response to organic substance | cellular developmental process | regulation of cellular biosynthetic process | response to wounding | positive regulation of steroid biosynthetic process | regulation of intracellular protein kinase cascade | anatomical structure development | regulation of multicellular organismal process | cell surface receptor signaling pathway | regulation of RNA biosynthetic process | negative regulation of programmed cell death | regulation of secretion | positive regulation of interleukin-6 production | immune response | cellular response to stimulus | response to copper ion | cell death | response to vitamin | organ development | regulation of protein secretion | positive regulation of ERK1 and ERK2 cascade | response to heat | regulation of nuclear division | negative regulation of biological process | response to L-ascorbic acid | positive regulation of cytokine production | regulation of JNK cascade | positive regulation of MAPK cascade | temperature homeostasis | positive regulation of protein transport | regulation of stress-activated MAPK cascade | regulation of cell communication | signaling | positive regulation of I-kappaB kinase/NF-kappaB cascade | regulation of transcription, DNA-dependent | response to organic cyclic compound | regulation of cytokine production | positive regulation of response to stimulus | response to biotic stimulus | regulation of developmental process | developmental process | response to external stimulus | positive regulation of cell cycle process | positive regulation of cellular process | regulation of transport | positive regulation of transcription, DNA-dependent | negative regulation of cell proliferation | heat generation | response to organic nitrogen | epithelial cell differentiation | single-multicellular organism process | single organism signaling | positive regulation of transcription from RNA polymerase II promoter | regulation of vascular endothelial growth factor production | regulation of lipid metabolic process | positive regulation of metabolic process | positive regulation of lipid metabolic process | acute inflammatory response | immune system process | cellular response to organic substance | regulation of protein localization | regulation of cell death | negative regulation of cell death | regulation of interleukin-6 production | positive regulation of angiogenesis | regulation of I-kappaB kinase/NF-kappaB cascade | regulation of cellular component organization | response to ionizing radiation | response to other organism | positive regulation of signaling | positive regulation of mitosis | signal transduction | regulation of signaling | positive regulation of gene expression | multicellular organismal process

GO Cellular Component

cell | cytoplasm | cell part | extracellular region | extracellular space | extracellular region part | cytoplasmic part | cytosol | cell surface | intracellular part | intracellular