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QuickView for Galantamine (compound)


PubChem
Name: Galantamine
PubChem Compound ID: 10827215
Description: A benzazepine derived from norbelladine. It is found in GALANTHUS and other AMARYLLIDACEAE. It is a cholinesterase inhibitor that has been used to reverse the muscular effects of GALLAMINE TRIETHIODIDE and TUBOCURARINE and has been studied as a treatment for ALZHEIMER DISEASE and other central nervous system disorders.
Molecular formula: C17H21NO3
Molecular weight: 288.36 g/mol
DrugBank
Identification
Name: Galantamine
Name (isomeric): DB00674
Drug Type: small molecule
Description: A benzazepine derived from norbelladine. It is found in GALANTHUS and other AMARYLLIDACEAE. It is a cholinesterase inhibitor that has been used to reverse the muscular effects of GALLAMINE TRIETHIODIDE and TUBOCURARINE and has been studied as a treatment for ALZHEIMER DISEASE and other central nervous system disorders.
Synonyms:
Galanthamine hydrobromide; (-)-Galanthamine; Galanthamine
Brand: Lycoremine, Reminyl, Galantamin, Lycoremin, Jilkon
Category: Parasympathomimetics, Nootropic Agents, Cholinesterase Inhibitors
CAS number: 357-70-0
Pharmacology
Indication: For the treatment of mild to moderate dementia of the Alzheimer's type. Has also been investigated in patients with mild cognitive impairment who did not meet the diagnostic criteria for Alzheimer's disease.
Pharmacology:
Galantamine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor. It is indicated for the treatment of mild to moderate dementia of the Alzheimer's type. An early pathophysiological feature of Alzheimer's disease that is associated with memory loss and cognitive deficits is a deficiency of acetylcholine as a result of selec...
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Mechanism of Action:
Galantamine is a phenanthrene alkaloid and a reversible, competitive acetylcholinesterase inhibitor. It is not structurally related to other acetylcholinesterase inhibitors. Galantamine's proposed mechanism of action involves the reversible inhibition of acetylcholinesterase, which prevents the hydrolysis of acetycholine, leading to an increased co...
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Protein binding: 18%
Route of elimination: Galantamine is metabolized by hepatic cytochrome P450 enzymes, glucuronidated, and excreted unchanged in the urine.
Half Life: 7 hours
Clearance: 300 mL/min [After IV. or oral administration]
Toxicity: LD50=75 mg/kg (rat)
Affected organisms: Humans and other mammals
Interactions
Food interaction:
Take with food.
Drug interaction:
OxybutyninPossible antagonism of action
MesoridazinePossible antagonism of action
DiphenhydraminePossible antagonism of action
TrimeprazinePossible antagonism of action
AzatadinePossible antagonism of action
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Targets


Enzymes