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QuickView for GRIK2 (gene)


Gene Symbol:
GRIK2 Homo sapiens Homo sapiens
Full name:
glutamate receptor, ionotropic, kainate 2
Synonyms:
EAA4, bA487F5.1, GLR6, GluK2, GLUK6, Glur-6, GLUR6, glutamate receptor 6, glutamate receptor form A, glutamate receptor form B, glutamate receptor form C, glutamate receptor form D, glutamate receptor form E, glutamate receptor, ionotropic kainate 2, glutamate receptor, ionotropic, kainate 2, excitatory amino acid receptor 4, OTTHUMP00000017949, OTTHUMP00000017950, MRT6, MGC74427
Genomic Location:
Chr 6: 101953675-102623474
Description:
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by th...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
YY1 binding site geneset 1 GATA2 binding site geneset 1 FOXQ1 binding site geneset 1 Unknown transcription factor binding site geneset 33 TCF11 MAFG binding site geneset 1 FOXI1 binding site geneset 1 Unknown transcription factor binding site geneset 57 E2F1 binding site geneset 1 Unknown transcription factor binding site geneset 64 Unknown transcription factor binding site geneset 71
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 6
6q16.3





GO Molecular Function

ligand-gated channel activity | passive transmembrane transporter activity | transmembrane signaling receptor activity | enzyme binding | transmembrane transporter activity | ligand-gated ion channel activity | binding | protein domain specific binding | small conjugating protein ligase binding | kainate selective glutamate receptor activity | ubiquitin conjugating enzyme binding | signaling receptor activity | transporter activity | identical protein binding | ion transmembrane transporter activity | gated channel activity | extracellular ligand-gated ion channel activity | glutamate receptor activity | substrate-specific transmembrane transporter activity | receptor activity | molecular transducer activity | protein binding | protein homodimerization activity | ionotropic glutamate receptor activity | ubiquitin protein ligase binding | protein dimerization activity | signal transducer activity | small protein conjugating enzyme binding | excitatory extracellular ligand-gated ion channel activity | extracellular-glutamate-gated ion channel activity | substrate-specific transporter activity | PDZ domain binding | channel activity | ion channel activity | substrate-specific channel activity

GO Biological Process

regulation of biological process | negative regulation of multicellular organismal process | regulation of transmission of nerve impulse | behavioral fear response | positive regulation of cell communication | regulation of programmed cell death | establishment of localization | neuron death | negative regulation of neuron death | regulation of biological quality | negative regulation of cellular process | ligand-gated channel activity | regulation of excitatory postsynaptic membrane potential | defense response | cellular chemical homeostasis | membrane organization | intracellular transport | cell-type specific apoptotic process | multicellular organismal signaling | regulation of response to stimulus | regulation of neuron death | positive regulation of neurological system process | cellular process | death | localization | cellular homeostasis | positive regulation of synaptic transmission | protein transport | passive transmembrane transporter activity | negative regulation of signaling | synaptic transmission | regulation of neuronal synaptic plasticity | macromolecule localization | negative regulation of apoptotic process | transmembrane signaling receptor activity | establishment of localization in cell | regulation of neurological system process | regulation of system process | regulation of cellular process | cellular component organization or biogenesis | regulation of apoptotic process | transmembrane transporter activity | ligand-gated ion channel activity | regulation of response to stress | cellular component organization | calcium ion homeostasis | response to stimulus | negative regulation of cell communication | response to chemical stimulus | transport | negative regulation of neurological system process | response to stress | intracellular protein transport | receptor clustering | programmed cell death | cellular localization | regulation of action potential in neuron | regulation of synaptic transmission | cell-cell signaling | metal ion homeostasis | regulation of membrane potential | regulation of cellular response to stress | negative regulation of neuron apoptotic process | regulation of long-term neuronal synaptic plasticity | apoptotic process | regulation of signal transduction | regulation of stress-activated protein kinase signaling cascade | regulation of synaptic transmission, glutamatergic | regulation of MAPK cascade | positive regulation of multicellular organismal process | membrane hyperpolarization | ion transmembrane transport | cellular membrane organization | regulation of postsynaptic membrane potential | protein localization to membrane | neurological system process | kainate selective glutamate receptor activity | cellular ion homeostasis | signaling receptor activity | single-organism process | neuron apoptotic process | induction of programmed cell death in response to chemical stimulus | transporter activity | ion transmembrane transporter activity | gated channel activity | synaptic transmission, glutamatergic | biological regulation | extracellular ligand-gated ion channel activity | glutamate receptor activity | substrate-specific transmembrane transporter activity | cation homeostasis | positive regulation of biological process | negative regulation of synaptic transmission, glutamatergic | cellular cation homeostasis | cell communication | induction of programmed cell death | regulation of neuron apoptotic process | system process | cellular calcium ion homeostasis | homeostatic process | multicellular organismal response to stress | fear response | regulation of inhibitory postsynaptic membrane potential | positive regulation of transmission of nerve impulse | ionotropic glutamate receptor activity | regulation of intracellular protein kinase cascade | regulation of multicellular organismal process | cell surface receptor signaling pathway | signal transducer activity | negative regulation of programmed cell death | cellular protein localization | chemical homeostasis | behavior | positive regulation of cell death | membrane depolarization | cellular response to stimulus | neuron-neuron synaptic transmission | cell death | excitatory extracellular ligand-gated ion channel activity | extracellular-glutamate-gated ion channel activity | positive regulation of programmed cell death | ion homeostasis | negative regulation of biological process | establishment of protein localization | negative regulation of transmission of nerve impulse | regulation of JNK cascade | substrate-specific transporter activity | regulation of stress-activated MAPK cascade | regulation of cell communication | transmembrane transport | regulation of action potential | signaling | single-organism behavior | protein localization | cellular macromolecule localization | channel activity | glutamate receptor signaling pathway | cellular divalent inorganic cation homeostasis | behavioral defense response | positive regulation of cellular process | cellular metal ion homeostasis | single-multicellular organism process | single organism signaling | transmission of nerve impulse | negative regulation of synaptic transmission | ion channel activity | regulation of synaptic plasticity | ion transport | regulation of cell death | negative regulation of cell death | ionotropic glutamate receptor signaling pathway | regulation of short-term neuronal synaptic plasticity | divalent inorganic cation homeostasis | substrate-specific channel activity | positive regulation of signaling | signal transduction | regulation of signaling | multicellular organismal process

GO Cellular Component

presynaptic membrane | integral to membrane | dendrite | synapse | plasma membrane part | neuron projection | cell body | cell | neuronal cell body | intrinsic to membrane | synaptic membrane | terminal button | cell projection part | cytoplasm | dendrite cytoplasm | receptor complex | synapse part | macromolecular complex | cell projection | postsynaptic membrane | cell projection cytoplasm | plasma membrane | perikaryon | axon part | kainate selective glutamate receptor complex | membrane part | integral to plasma membrane | cell part | axon terminus | cell periphery | cytoplasmic part | axon | ionotropic glutamate receptor complex | neuron projection terminus | intracellular part | intracellular | cell junction | membrane | protein complex | intrinsic to plasma membrane