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QuickView for GRIA1 (gene)


Gene Symbol:
GRIA1 Homo sapiens Homo sapiens
Full name:
glutamate receptor, ionotropic, AMPA 1
Synonyms:
MGC133252, HBGR1, GluA1, GLUH1, Glur-1, gluR-A, gluR-K1, GLUR1, GLURA, glutamate receptor 1, glutamate receptor, ionotropic, AMPA 1, AMPA 1, AMPA-selective glutamate receptor 1
Genomic Location:
Chr 5: 152850499-153171354
Description:
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classifica...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
TCF3 binding site geneset 2 RORA binding site geneset 1 RORA binding site geneset 2 JUN binding site geneset 6 RFX1 binding site geneset 1 NFE2L1 binding site geneset 1 PAX4 binding site geneset 2 EN1 binding site geneset 1 TGIF binding site geneset 1 BACH2 binding site geneset 1
Cytogenetic Map:
chr 5
5q31.1





GO Molecular Function

ligand-gated channel activity | passive transmembrane transporter activity | transmembrane signaling receptor activity | transmembrane transporter activity | ligand-gated ion channel activity | binding | protein domain specific binding | kainate selective glutamate receptor activity | signaling receptor activity | transporter activity | ion transmembrane transporter activity | gated channel activity | alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity | extracellular ligand-gated ion channel activity | glutamate receptor activity | substrate-specific transmembrane transporter activity | receptor activity | molecular transducer activity | protein binding | ionotropic glutamate receptor activity | signal transducer activity | excitatory extracellular ligand-gated ion channel activity | extracellular-glutamate-gated ion channel activity | substrate-specific transporter activity | PDZ domain binding | channel activity | ion channel activity | substrate-specific channel activity

GO Biological Process

regulation of biological process | long-term memory | establishment of localization | ligand-gated channel activity | cellular macromolecule metabolic process | multicellular organismal signaling | cellular process | localization | passive transmembrane transporter activity | synaptic transmission | transmembrane signaling receptor activity | regulation of cellular process | transmembrane transporter activity | ligand-gated ion channel activity | response to stimulus | transport | cell-cell signaling | learning or memory | ion transmembrane transport | neurological system process | kainate selective glutamate receptor activity | signaling receptor activity | single-organism process | vesicle-mediated transport | transporter activity | ion transmembrane transporter activity | gated channel activity | cognition | alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity | biological regulation | extracellular ligand-gated ion channel activity | glutamate receptor activity | substrate-specific transmembrane transporter activity | cell communication | receptor internalization | system process | ionotropic glutamate receptor activity | cell surface receptor signaling pathway | signal transducer activity | metabolic process | endocytosis | behavior | cellular response to stimulus | excitatory extracellular ligand-gated ion channel activity | extracellular-glutamate-gated ion channel activity | memory | substrate-specific transporter activity | transmembrane transport | signaling | single-organism behavior | channel activity | glutamate receptor signaling pathway | receptor-mediated endocytosis | receptor metabolic process | single-multicellular organism process | single organism signaling | transmission of nerve impulse | ion channel activity | ion transport | cellular metabolic process | ionotropic glutamate receptor signaling pathway | substrate-specific channel activity | signal transduction | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

endoplasmic reticulum part | dendritic spine | integral to membrane | dendrite | intracellular membrane-bounded organelle | synapse | plasma membrane part | neuron projection | endocytic vesicle membrane | organelle membrane | cell projection membrane | cytoplasmic vesicle | cell body | cell | neuronal cell body | intrinsic to membrane | synaptic membrane | intracellular non-membrane-bounded organelle | cell projection part | cytoplasm | intracellular organelle | receptor complex | endoplasmic reticulum | leading edge membrane | synapse part | nuclear outer membrane-endoplasmic reticulum membrane network | macromolecular complex | cell projection | postsynaptic membrane | endomembrane system | neuron spine | endoplasmic reticulum membrane | plasma membrane | organelle part | cell leading edge | intracellular organelle part | dendritic spine head | vesicle | postsynaptic density | membrane part | integral to plasma membrane | cell part | dendrite membrane | membrane-bounded organelle | organelle | vesicle membrane | cell periphery | cytoplasmic part | cytoplasmic membrane-bounded vesicle | ionotropic glutamate receptor complex | cytoplasmic vesicle part | membrane-bounded vesicle | non-membrane-bounded organelle | cell surface | cytoskeleton | intracellular part | endocytic vesicle | intracellular | cell junction | membrane | cytoskeletal part | cytoplasmic vesicle membrane | neuron projection membrane | protein complex | alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex | intrinsic to plasma membrane