Clear Search sequence regions
Bookmark Forward Export SNPs

QuickView for GATA1 (gene)


Gene Symbol:
GATA1 Homo sapiens Homo sapiens
Full name:
GATA binding protein 1 (globin transcription factor 1)
Synonyms:
OTTHUMP00000023259, NF-E1 DNA-binding protein, NFE1, GATA binding protein 1, GATA binding protein 1 (globin transcription factor 1), GATA-1, GATA-binding factor 1, GF-1, GF1, globin transcription factor 1, ERYF1, erythroid transcription factor, erythroid transcription factor 1, transcription factor GATA1, XLANP, XLTDA, XLTT
Genomic Location:
Chr X: 48529906-48537662
Description:
This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. [provided by RefSeq]
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Canis lupus familiaris Bos taurus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
TFAP4 binding site geneset 1 Unknown transcription factor binding site geneset 3 PCAF binding site geneset 1 Unknown transcription factor binding site geneset 8 TFCP2 binding site geneset 1 Unknown transcription factor binding site geneset 20 GATA1 binding site geneset 3 GATA1 binding site geneset 4 PITX2 binding site geneset 1 GATA1 binding site geneset 5
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr X
Xp11.23


Transcripts Names
NM_002049
Protein Names
Q96GB8
P15976



GO Molecular Function

sequence-specific DNA binding | regulatory region DNA binding | transcription regulatory region DNA binding | sequence-specific DNA binding RNA polymerase II transcription factor activity | RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription | enhancer binding | cation binding | core promoter proximal region sequence-specific DNA binding | nucleic acid binding | nucleic acid binding transcription factor activity | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription | binding | chromatin binding | protein domain specific binding | enhancer sequence-specific DNA binding | RNA polymerase II regulatory region DNA binding | p53 binding | DNA binding | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription | ion binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | DNA binding, bending | protein binding | zinc ion binding | RNA polymerase II core promoter proximal region sequence-specific DNA binding | C2H2 zinc finger domain binding | RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription | sequence-specific DNA binding transcription factor activity | transcription factor binding | regulatory region nucleic acid binding | RNA polymerase II transcription factor binding | RNA polymerase II regulatory region sequence-specific DNA binding | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity | transition metal ion binding | core promoter proximal region DNA binding | metal ion binding | heterocyclic compound binding

GO Biological Process

RNA metabolic process | transcription from RNA polymerase II promoter | cell morphogenesis | regulation of biological process | negative regulation of multicellular organismal process | positive regulation of macromolecule biosynthetic process | developmental process involved in reproduction | regulation of biosynthetic process | gonad development | regulation of programmed cell death | positive regulation of peptidyl-tyrosine phosphorylation | erythrocyte homeostasis | eosinophil fate commitment | regulation of osteoblast proliferation | nucleic acid metabolic process | response to hormone stimulus | regulation of immune system process | myeloid cell differentiation | regulation of biological quality | negative regulation of cellular process | sequence-specific DNA binding RNA polymerase II transcription factor activity | RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription | cell differentiation | cellular macromolecule metabolic process | positive regulation of phosphate metabolic process | regulation of protein modification process | positive regulation of cellular biosynthetic process | cellular process | chromatin organization | regulation of definitive erythrocyte differentiation | reproductive system development | immune system development | hemostasis | negative regulation of apoptotic process | Sertoli cell differentiation | regulation of myeloid cell differentiation | positive regulation of nitrogen compound metabolic process | regulation of nucleobase-containing compound metabolic process | cellular response to chemical stimulus | negative regulation of cellular metabolic process | regulation of bone mineralization | regulation of binding | regulation of cell differentiation | regulation of cellular process | cellular component organization or biogenesis | regulation of apoptotic process | regulation of metabolic process | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | basophil differentiation | cellular component organization | platelet aggregation | negative regulation of biomineral tissue development | development of primary sexual characteristics | response to stimulus | nucleic acid binding transcription factor activity | regulation of glycoprotein biosynthetic process | response to chemical stimulus | regulation of peptidyl-tyrosine phosphorylation | positive regulation of protein metabolic process | positive regulation of anti-apoptosis | response to stress | regulation of macromolecule biosynthetic process | posttranscriptional regulation of gene expression | regulation of cell proliferation | positive regulation of nucleobase-containing compound metabolic process | macromolecule biosynthetic process | regulation of transcription regulatory region DNA binding | reproduction | cellular nitrogen compound metabolic process | regulation of DNA binding | response to endogenous stimulus | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription | negative regulation of metabolic process | platelet formation | hemopoiesis | cellular biosynthetic process | embryo development | cell-cell signaling | blood coagulation | leukocyte differentiation | cellular response to hormone stimulus | system development | nitrogen compound metabolic process | reproductive process | multicellular organismal development | positive regulation of RNA metabolic process | negative regulation of RNA metabolic process | response to follicle-stimulating hormone stimulus | embryonic hemopoiesis | regulation of phosphorylation | regulation of ossification | wound healing | regulation of gene expression | platelet activation | platelet morphogenesis | cellular response to gonadotropin stimulus | myeloid leukocyte differentiation | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of multicellular organismal development | regulation of macromolecule metabolic process | regulation of nitrogen compound metabolic process | single-organism process | negative regulation of nitrogen compound metabolic process | negative regulation of DNA binding | regulation of anti-apoptosis | regulation of transcription from RNA polymerase II promoter | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription | negative regulation of binding | homeostasis of number of cells | eosinophil differentiation | granulocyte differentiation | biological regulation | biosynthetic process | gene looping | regulation of primary metabolic process | regulation of cellular protein metabolic process | negative regulation of transcription regulatory region DNA binding | regulation of biomineral tissue development | positive regulation of macromolecule metabolic process | megakaryocyte differentiation | cell morphogenesis involved in differentiation | positive regulation of biological process | erythrocyte development | regulation of cellular macromolecule biosynthetic process | negative regulation of developmental process | positive regulation of phosphorus metabolic process | negative regulation of nucleobase-containing compound metabolic process | chordate embryonic development | cell communication | regulation of cellular metabolic process | cellular process involved in reproduction | transcriptional activation by promoter-enhancer looping | regulation of protein metabolic process | positive regulation of biosynthetic process | positive regulation of osteoblast proliferation | homeostatic process | positive regulation of cell proliferation | regulation of protein phosphorylation | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | coagulation | cellular component organization at cellular level | development of primary male sexual characteristics | cellular response to thyroid hormone stimulus | RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription | sequence-specific DNA binding transcription factor activity | positive regulation of protein modification process | response to organic substance | negative regulation of bone mineralization | cellular developmental process | regulation of cellular biosynthetic process | negative regulation of macromolecule biosynthetic process | male sex differentiation | response to wounding | negative regulation of ossification | Sertoli cell development | anatomical structure development | regulation of multicellular organismal process | metabolic process | cell fate commitment | dendritic cell differentiation | primary metabolic process | regulation of homeostatic process | regulation of RNA biosynthetic process | regulation of body fluid levels | negative regulation of transcription, DNA-dependent | negative regulation of programmed cell death | embryonic organ development | male gonad development | regulation of erythrocyte differentiation | cell adhesion | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity | cellular response to stimulus | nucleobase-containing compound metabolic process | single organism reproductive process | organic substance metabolic process | cellular component morphogenesis | negative regulation of biosynthetic process | negative regulation of gene expression | organ development | gene expression | cellular response to endogenous stimulus | cellular response to cAMP | regulation of phosphate metabolic process | negative regulation of biological process | cell-cell adhesion | transcription, DNA-dependent | response to gonadotropin stimulus | response to cAMP | cell activation | cellular response to follicle-stimulating hormone stimulus | anatomical structure formation involved in morphogenesis | negative regulation of molecular function | signaling | regulation of transcription, DNA-dependent | negative regulation of macromolecule metabolic process | cell development | regulation of molecular function | cellular component organization or biogenesis at cellular level | positive regulation of phosphorylation | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | reproductive structure development | regulation of developmental process | developmental process | organelle organization | erythrocyte differentiation | response to thyroid hormone stimulus | negative regulation of cellular biosynthetic process | positive regulation of cellular process | negative regulation of transcription from RNA polymerase II promoter | positive regulation of transcription, DNA-dependent | negative regulation of cell proliferation | single-multicellular organism process | single organism signaling | positive regulation of transcription from RNA polymerase II promoter | heterocycle metabolic process | negative regulation of cellular macromolecule biosynthetic process | in utero embryonic development | positive regulation of metabolic process | chromosome organization | immune system process | cellular metabolic process | hemopoietic or lymphoid organ development | cellular response to organic substance | sex differentiation | regulation of cell death | regulation of translation | negative regulation of cell death | biological adhesion | homotypic cell-cell adhesion | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | organelle membrane | nuclear membrane | cell | nuclear lumen | transcription factor complex | nucleolus | intracellular non-membrane-bounded organelle | intracellular organelle | macromolecular complex | endomembrane system | nuclear part | nucleoplasm | nuclear envelope | organelle part | intracellular organelle part | organelle lumen | envelope | nucleoplasm part | organelle envelope | cell part | membrane-bounded organelle | transcriptional repressor complex | nucleus | organelle | membrane-enclosed lumen | intracellular organelle lumen | non-membrane-bounded organelle | intracellular part | intracellular | membrane | protein complex