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QuickView for Ethotoin (compound)


PubChem
Name: ethotoin
PubChem Compound ID: 3292
Molecular formula: C11H12N2O2
Molecular weight: 204.225 g/mol
Synonyms:
C07839; Accenon (TN); Etotoina [INN-Spanish]; Ethotoine [INN-French]; 3-Ethyl-5-phenylimidazolidin-2,4-dione; Ethotoinum [INN-Latin]; Hydantoin, 3-ethyl-5-phenyl-; Ethotoin [BAN:INN:JAN]; 86-35-1; 3-Ethyl-5-phenylhydantoin.
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DrugBank
Identification
Name: ethotoin
Name (isomeric): DB00754
Drug Type: small molecule
Synonyms:
Ethotoine [INN-French]; Etotoina [INN-Spanish]; Ethotoinum [INN-Latin]
Brand: Pegoanone, Peganone, Accenon
Category: Anticonvulsants
CAS number: 86-35-1
Pharmacology
Indication: For the control of tonic-clonic (grand mal) and complex partial (psychomotor) seizures.
Pharmacology:
Ethotoin is a hydantoin derivative and anticonvulsant. Ethotoin exerts an antiepileptic effect without causing general central nervous system depression. The mechanism of action is probably very similar to that of phenytoin. The latter drug appears to stabilize rather than to raise the normal seizure threshold, and to prevent the spread of seizure ...
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Mechanism of Action:
The mechanism of action is probably very similar to that of phenytoin. The latter drug appears to stabilize rather than to raise the normal seizure threshold, and to prevent the spread of seizure activity rather than to abolish the primary focus of seizure discharges. Ethotoin inhibits nerve impulses in the motor cortex by lowering sodium ion influ...
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Absorption: Fairly rapidly absorbed, however, the extent of oral absorption is not known.
Biotransformation: Hepatic. The drug exhibits saturable metabolism with respect to the formation of N-deethyl and p-hydroxyl-ethotoin, the major metabolites.
Half Life: 3 to 9 hours
Toxicity: Symptoms of overdose include drowsiness, loss of or impaired muscle coordination, nausea, visual disturbance, and, at very high doses, coma.
Affected organisms: Humans and other mammals
Interactions
Drug interaction:
AprepitantThe CYP3A4 inducer, ethotoin, may decrease the effect of aprepitant.
FluvoxamineIncreases the effect of hydantoin
MedroxyprogesteroneThe enzyme inducer, ethotoin, decreases the effect of the hormone agent, medroxyprogesterone.
Ethinyl EstradiolThis product may cause a slight decrease of contraceptive effect
CapecitabineCapecitabine increases the effect of hydantoin
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Targets


Enzymes