Clear Search sequence regions
Bookmark Forward

QuickView for Ethacrynic acid (compound)


PubChem
Name: Ethacrynic Acid
PubChem Compound ID: 222525
Description: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
Molecular formula: C14H16N2O4
Molecular weight: 276.288 g/mol
Synonyms:
NSC8791; 5422-28-6; Etacrynic acid
DrugBank
Identification
Name: Ethacrynic Acid
Name (isomeric): DB00903
Drug Type: small molecule
Description: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
Synonyms:
Etacrinic acid; Methylenebutyrylphenoxyacetic acid; Etakrinic acid; Ethacryinic Acid; Etacrynic acid; Ethacrynate
Brand: Endecril, Edecrina, Otacril, Uregit, Mingit, Hydromedin, Taladren, Reomax, Hidromedin, Crinuryl, Edecril, Edecrin
Category: Diuretics, Enzyme Inhibitors
CAS number: 58-54-8
Pharmacology
Indication: For the treatment of high blood pressure and edema caused by diseases like congestive heart failure, liver failure, and kidney failure.
Pharmacology:
Ethacrynic acid is a monosulfonamyl loop or high ceiling diuretic. Ethacrynic acid acts on the ascending limb of the loop of Henle and on the proximal and distal tubules. Urinary output is usually dose dependent and related to the magnitude of fluid accumulation. Water and electrolyte excretion may be increased several times over that observed with...
show more »
Mechanism of Action:
Ethacrynic acid inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. Diuretics also lower blood pressure initially by reducing plasma an...
show more »
Absorption: Onset of action is rapid, usually within 30 minutes after an oral dose of ethacrynic acid or within 5 minutes after an intravenous injection of ethacrynic acid.
Protein binding: > 98%
Biotransformation: Hepatic.
Toxicity: Overdosage may lead to excessive diuresis with electrolyte depletion.
Affected organisms: Humans and other mammals
Interactions
Food interaction:
Take with food to reduce irritation.
Drug interaction:
DigitoxinPossible electrolyte variations and arrhythmias
KanamycinIncreased ototoxicity
GinsengGinseng may decrease the therapeutic effect of diuretic, ethacrynic acid.
DigoxinPossible electrolyte variations and arrhythmias
CisplatinIncreased ototoxicity
show more »

Targets


Enzymes


Transporters


Carriers