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PubChem
Name: Edrophonium
PubChem Compound ID: 3202
Description: A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles.
Molecular formula: C10H16NO+
Molecular weight: 166.24 g/mol
Synonyms:
NCGC00015409-02; Prestwick0_000083; NCGC00015409-01; 116-38-1; Edrophonum; Prestwick1_000083; EDR; 312-48-1; Spectrum2_001110; NINDS_000809.
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DrugBank
Identification
Name: Edrophonium
Name (isomeric): DB01010
Drug Type: small molecule
Description: A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles.
Synonyms:
Edrophone Chloride; EDR; Edrophonum; Edrophonium Ion; Edrophonium Chloride
Brand: Tensilon chloride, Reversol, Tensilon, Antirex, Enlon, Enlon Plus
Category: Cholinesterase Inhibitors, Antidotes
CAS number: 116-38-1
Pharmacology
Indication: For the differential diagnosis of myasthenia gravis and as an adjunct in the evaluation of treatment requirements in this disease. It may also be used for evaluating emergency treatment in myasthenic crises.
Pharmacology:
Edrophonium is a short and rapid-acting anticholinesterase drug. Its effect is manifest within 30 to 60 seconds after injection and lasts an average of 10 minutes. Edrophonium's pharmacologic action is due primarily to the inhibition or inactivation of acetylcholinesterase at sites of cholinergic transmission. Muscarinic receptors are found through...
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Mechanism of Action: Edrophonium works by prolonging the action acetylcholine, which is found naturally in the body. It does this by inhibiting the action of the enzyme acetylcholinesterase. Acetylcholine stimulates nicotinic and muscarinic receptors. When stimulated, these receptors have a range of effects.
Absorption: Rapidly absorbed.
Route of elimination: Edrophonium is primarily renally excreted with 67% of the dose appearing in the urine. Hepatic metabolism and biliary excretion have also been demonstrated in animals
Half Life: Distribution half-life is 7 to 12 minutes. Elimination half-life is 33 to 110 minutes.
Clearance: 6.8 +/- 2. mL/kg/min [Adults] 6.4 +/- 3.9 mL/kg/min [Children (0.08-10 yrs)] 2.9 +/- 1.9 mL/kg/min [Elderly (65-75 yrs)]
Toxicity: With drugs of this type, muscarine-like symptoms (nausea, vomiting, diarrhea, sweating, increased bronchial and salivary secretions and bradycardia) often appear with overdosage (cholinergic crisis).
Affected organisms: Humans and other mammals
Interactions
Drug interaction:
PrednisoneThe corticosteroid, prednisone, may decrease the effect of the anticholinesterase, edrophonium.
TacrineThe acetylcholinesterase inhibitor, Tacrine, may increase the adverse/toxic effects of Edrophonium, a cholinergic agonist. Monitor for increased cholinergic effects and toxicity.
FludrocortisoneThe corticosteroid, fludrocortisone, may decrease the effect of the anticholinesterase, edrophonium.
TriamcinoloneThe corticosteroid, triamcinolone, may decrease the effect of the anticholinesterase, edrophonium.
BetamethasoneThe corticosteroid, betamethasone, may decrease the effect of the anticholinesterase, edrophonium.
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Targets