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QuickView for ERBB2 (gene)


Gene Symbol:
ERBB2 Homo sapiens Homo sapiens
Full name:
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
Synonyms:
p185erbB2, NGL, NEU, neuroblastoma/glioblastoma derived oncogene homolog, metastatic lymph node gene 19 protein, MLN 19, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog), proto-oncogene c-ErbB-2, proto-oncogene Neu, receptor tyrosine-protein kinase erbB-2, tyrosine kinase-type cell surface receptor HER2, TKR1, CD340, c-erb B2, c-erb B2/neu protein, erbB-2, HER-2, HER-2/neu, HER2, herstatin
Genomic Location:
Chr 17: 35097919-35138441
Description:
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing k...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Canis lupus familiaris Gallus gallus Pan troglodytes Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: miRecords):
Cytogenetic Map:
chr 17
17q12


Transcripts Names
NM_001005862
NM_004448



GO Molecular Function

transmembrane receptor protein tyrosine kinase activity | epidermal growth factor-activated receptor activity | RNA polymerase binding | transmembrane signaling receptor activity | enzyme binding | ribonucleotide binding | nucleotide binding | receptor binding | growth factor binding | binding | catalytic activity | ErbB-3 class receptor binding | receptor signaling protein activity | ATP binding | adenyl nucleotide binding | signaling receptor activity | purine nucleotide binding | RNA polymerase core enzyme binding | identical protein binding | transmembrane receptor protein kinase activity | protein heterodimerization activity | organic cyclic compound binding | nucleoside phosphate binding | receptor activity | molecular transducer activity | purine ribonucleoside triphosphate binding | protein tyrosine kinase activity | protein binding | RNA polymerase I core binding | protein phosphatase binding | protein dimerization activity | signal transducer activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | kinase activity | phosphatase binding | heterocyclic compound binding | protein C-terminus binding | small molecule binding | receptor signaling protein tyrosine kinase activity

GO Biological Process

RNA metabolic process | regulation of ERK1 and ERK2 cascade | cell morphogenesis | regulation of biological process | positive regulation of macromolecule biosynthetic process | neuron projection morphogenesis | intracellular signal transduction | regulation of biosynthetic process | transmembrane receptor protein tyrosine kinase activity | regulation of transcription from RNA polymerase I promoter | nucleic acid metabolic process | regulation of MAP kinase activity | cell differentiation | positive regulation of epithelial cell proliferation | cellular macromolecule metabolic process | regulation of purine nucleotide catabolic process | nervous system development | cell part morphogenesis | neurogenesis | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | regulation of protein modification process | generation of neurons | epidermal growth factor-activated receptor activity | regulation of response to stimulus | positive regulation of GTPase activity | positive regulation of cellular biosynthetic process | cellular process | positive regulation of Ras GTPase activity | cell projection morphogenesis | neuron development | positive regulation of protein kinase activity | axon guidance | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | transmembrane signaling receptor activity | regulation of nucleobase-containing compound metabolic process | regulation of transcription from RNA polymerase III promoter | regulation of angiogenesis | regulation of cellular process | cellular component organization or biogenesis | positive regulation of cell growth | regulation of metabolic process | epidermal growth factor receptor signaling pathway | organic cyclic compound metabolic process | positive regulation of translation | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | regulation of vasculature development | response to stimulus | cell morphogenesis involved in neuron differentiation | response to chemical stimulus | positive regulation of protein metabolic process | signal transduction by phosphorylation | response to stress | regulation of macromolecule biosynthetic process | posttranscriptional regulation of gene expression | regulation of cell proliferation | positive regulation of nucleobase-containing compound metabolic process | regulation of anatomical structure morphogenesis | phosphatidylinositol-mediated signaling | macromolecule biosynthetic process | positive regulation of transcription from RNA polymerase III promoter | cardiovascular system development | cellular nitrogen compound metabolic process | ERBB signaling pathway | positive regulation of protein serine/threonine kinase activity | protein modification process | regulation of cell adhesion | cellular biosynthetic process | macromolecule modification | catalytic activity | locomotion | receptor signaling protein activity | system development | nitrogen compound metabolic process | regulation of signal transduction | multicellular organismal development | positive regulation of RNA metabolic process | regulation of MAPK cascade | phosphorus metabolic process | mammary gland development | taxis | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | wound healing | regulation of small GTPase mediated signal transduction | regulation of gene expression | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of multicellular organismal development | regulation of macromolecule metabolic process | regulation of transferase activity | signaling receptor activity | protein autophosphorylation | regulation of nitrogen compound metabolic process | single-organism process | enzyme linked receptor protein signaling pathway | transmembrane receptor protein kinase activity | axonogenesis | positive regulation of hydrolase activity | regulation of Rho protein signal transduction | biological regulation | cell proliferation | biosynthetic process | regulation of primary metabolic process | regulation of cellular protein metabolic process | phosphorylation | inositol lipid-mediated signaling | positive regulation of macromolecule metabolic process | regulation of GTPase activity | protein phosphorylation | cell morphogenesis involved in differentiation | regulation of cellular catabolic process | positive regulation of biological process | phosphate-containing compound metabolic process | regulation of purine nucleotide metabolic process | regulation of cellular macromolecule biosynthetic process | positive regulation of phosphorus metabolic process | regulation of nucleotide metabolic process | cell communication | positive regulation of transferase activity | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of protein metabolic process | positive regulation of biosynthetic process | heart development | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of RNA metabolic process | regulation of microtubule-based process | regulation of catabolic process | protein tyrosine kinase activity | positive regulation of molecular function | neuron differentiation | cellular component organization at cellular level | regulation of GTP catabolic process | protein metabolic process | positive regulation of protein modification process | regulation of growth | gland development | cellular developmental process | regulation of cellular biosynthetic process | regulation of kinase activity | response to wounding | regulation of intracellular protein kinase cascade | phosphatidylinositol 3-kinase cascade | anatomical structure development | regulation of multicellular organismal process | regulation of nucleotide catabolic process | cell surface receptor signaling pathway | signal transducer activity | cell projection organization | metabolic process | transferase activity, transferring phosphorus-containing groups | primary metabolic process | regulation of RNA biosynthetic process | phosphotransferase activity, alcohol group as acceptor | positive regulation of Rho GTPase activity | cellular response to stimulus | nucleobase-containing compound metabolic process | protein kinase activity | neuron projection development | organic substance metabolic process | regulation of hydrolase activity | cellular component morphogenesis | organ development | gene expression | positive regulation of transcription from RNA polymerase I promoter | positive regulation of kinase activity | transferase activity | regulation of phosphate metabolic process | regulation of nucleoside metabolic process | transcription, DNA-dependent | anatomical structure formation involved in morphogenesis | regulation of cell communication | signaling | positive regulation of growth | regulation of transcription, DNA-dependent | cell development | regulation of molecular function | regulation of epithelial cell proliferation | cellular component organization or biogenesis at cellular level | positive regulation of phosphorylation | cellular protein metabolic process | regulation of Ras protein signal transduction | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | positive regulation of MAP kinase activity | regulation of Ras GTPase activity | regulation of developmental process | kinase activity | developmental process | response to external stimulus | regulation of cell growth | cellular protein modification process | positive regulation of cellular process | positive regulation of transcription, DNA-dependent | regulation of Rho GTPase activity | single-multicellular organism process | single organism signaling | heterocycle metabolic process | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | cellular metabolic process | regulation of translation | circulatory system development | chemotaxis | regulation of cellular component organization | signal transduction | regulation of signaling | receptor signaling protein tyrosine kinase activity | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

integral to membrane | intracellular membrane-bounded organelle | plasma membrane part | endosomal part | organelle membrane | cell | intrinsic to membrane | cytoplasm | intracellular organelle | receptor complex | endosome membrane | macromolecular complex | plasma membrane | organelle part | intracellular organelle part | perinuclear region of cytoplasm | membrane part | cell part | endosome | membrane-bounded organelle | nucleus | organelle | cell periphery | cytoplasmic part | basolateral plasma membrane | intracellular part | intracellular | membrane | protein complex