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QuickView for EGFR (gene)


Gene Symbol:
EGFR Homo sapiens Homo sapiens
Full name:
epidermal growth factor receptor
Synonyms:
proto-oncogene c-ErbB-1, receptor tyrosine-protein kinase erbB-1, mENA, PIG61, epidermal growth factor receptor, ERBB, ERBB1, HER1, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, cell growth inhibiting protein 40, cell proliferation-inducing protein 61
Genomic Location:
Chr 7: 55054219-55242525
Description:
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autopho...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Gallus gallus Canis lupus familiaris Bos taurus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
miRNA binding sites
(Source: miRecords):
Cytogenetic Map:
chr 7
7p12





GO Molecular Function

actin binding | transmembrane receptor protein tyrosine kinase activity | actin filament binding | epidermal growth factor-activated receptor activity | receptor signaling protein serine/threonine kinase activity | transmembrane signaling receptor activity | enzyme binding | nucleic acid binding | ribonucleotide binding | nucleotide binding | protein serine/threonine kinase activity | binding | catalytic activity | receptor signaling protein activity | ATP binding | cytoskeletal protein binding | adenyl nucleotide binding | structure-specific DNA binding | MAP kinase kinase kinase activity | DNA binding | signaling receptor activity | purine nucleotide binding | identical protein binding | transmembrane receptor protein kinase activity | protein heterodimerization activity | organic cyclic compound binding | nucleoside phosphate binding | receptor activity | molecular transducer activity | purine ribonucleoside triphosphate binding | protein tyrosine kinase activity | protein binding | double-stranded DNA binding | protein phosphatase binding | protein dimerization activity | signal transducer activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | nitric-oxide synthase regulator activity | protein kinase activity | transferase activity | purine ribonucleotide binding | enzyme regulator activity | adenyl ribonucleotide binding | kinase activity | phosphatase binding | heterocyclic compound binding | small molecule binding | receptor signaling protein tyrosine kinase activity

GO Biological Process

positive regulation of cyclin-dependent protein kinase activity | brain development | molting cycle | response to radiation | cell morphogenesis | regulation of biological process | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | regulation of intracellular protein transport | positive regulation of cyclin-dependent protein kinase activity involved in G1/S | cell motility | neuron projection morphogenesis | regulation of cellular localization | intracellular signal transduction | regulation of localization | morphogenesis of an epithelium | regulation of biosynthetic process | positive regulation of cell communication | regulation of programmed cell death | transmembrane receptor protein tyrosine kinase activity | regulation of nitric oxide biosynthetic process | negative regulation of cellular process | regulation of MAP kinase activity | regulation of DNA metabolic process | cell differentiation | positive regulation of epithelial cell proliferation | positive regulation of fibroblast proliferation | cell cycle phase | cellular macromolecule metabolic process | nervous system development | positive regulation of transmembrane transport | cell part morphogenesis | neurogenesis | positive regulation of phosphate metabolic process | regulation of protein modification process | regulation of DNA replication | positive regulation of cellular component movement | generation of neurons | membrane organization | salivary gland morphogenesis | regulation of DNA repair | epidermal growth factor-activated receptor activity | regulation of response to stimulus | positive regulation of cellular biosynthetic process | cellular process | regulation of cell motility | localization | cell projection morphogenesis | forebrain cell migration | negative regulation of signaling | neuron development | positive regulation of protein kinase activity | macromolecule localization | negative regulation of apoptotic process | digestive tract morphogenesis | axon guidance | receptor signaling protein serine/threonine kinase activity | regulation of cell cycle | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | transmembrane signaling receptor activity | regulation of nucleobase-containing compound metabolic process | activation of phospholipase C activity | tissue development | regulation of protein kinase B signaling cascade | regulation of cellular process | cellular component organization or biogenesis | regulation of apoptotic process | regulation of metabolic process | epidermal growth factor receptor signaling pathway | positive regulation of cellular protein metabolic process | regulation of response to stress | epithelium development | negative regulation of epidermal growth factor receptor signaling pathway | cellular component organization | positive regulation of response to DNA damage stimulus | MAPK cascade | response to UV | response to stimulus | negative regulation of cell communication | cell morphogenesis involved in neuron differentiation | regulation of transmembrane transport | response to chemical stimulus | regulation of peptidyl-tyrosine phosphorylation | positive regulation of protein metabolic process | signal transduction by phosphorylation | activation of phospholipase A2 activity | gland morphogenesis | response to stress | regulation of macromolecule biosynthetic process | regulation of cell proliferation | positive regulation of nucleobase-containing compound metabolic process | telencephalon cell migration | protein serine/threonine kinase activity | activation of phospholipase A2 activity by calcium-mediated signaling | cellular localization | positive regulation of lipase activity | ERBB signaling pathway | regulation of protein transport | negative regulation of metabolic process | positive regulation of protein serine/threonine kinase activity | protein modification process | embryo development | macromolecule modification | activation of protein kinase activity | regulation of intracellular transport | catalytic activity | embryonic placenta development | regulation of cellular response to stress | locomotion | positive regulation of phospholipase C activity | receptor signaling protein activity | response to light stimulus | system development | regulation of cyclin-dependent protein kinase activity | regulation of signal transduction | multicellular organismal development | cell migration | response to UV-A | positive regulation of DNA replication | regulation of MAPK cascade | phosphorus metabolic process | cell cycle process | taxis | positive regulation of protein kinase B signaling cascade | intracellular protein kinase cascade | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | cellular membrane organization | regulation of nitric-oxide synthase activity | localization within membrane | telencephalon development | response to abiotic stimulus | positive regulation of cell cycle | interphase | cell cycle | positive regulation of intracellular protein transport | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of macromolecule metabolic process | MAP kinase kinase kinase activity | regulation of protein localization to nucleus | regulation of transferase activity | signaling receptor activity | protein autophosphorylation | regulation of nitrogen compound metabolic process | single-organism process | regulation of cell migration | enzyme linked receptor protein signaling pathway | positive regulation of intracellular protein kinase cascade | regulation of cellular component movement | morphogenesis of an epithelial fold | negative regulation of catabolic process | transmembrane receptor protein kinase activity | axonogenesis | positive regulation of hydrolase activity | second-messenger-mediated signaling | positive regulation of phospholipase A2 activity | positive regulation of cell migration | biological regulation | cell proliferation | regulation of primary metabolic process | cellular component movement | regulation of cellular protein metabolic process | protein insertion into membrane | phosphorylation | interphase of mitotic cell cycle | digestive tract development | regulation of phospholipase activity | positive regulation of macromolecule metabolic process | epidermis development | cerebral cortex cell migration | molting cycle process | protein phosphorylation | cell morphogenesis involved in differentiation | positive regulation of biological process | phosphate-containing compound metabolic process | regulation of cellular macromolecule biosynthetic process | negative regulation of response to stimulus | positive regulation of phosphorus metabolic process | chordate embryonic development | cell communication | positive regulation of transferase activity | regulation of cellular metabolic process | regulation of protein kinase activity | activation of MAPKK activity | regulation of protein metabolic process | positive regulation of signal transduction | positive regulation of biosynthetic process | G1/S transition of mitotic cell cycle | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of locomotion | embryo development ending in birth or egg hatching | positive regulation of transport | cerebral cortex development | regulation of catabolic process | protein tyrosine kinase activity | regulation of phospholipase C activity | positive regulation of molecular function | regulation of nucleocytoplasmic transport | calcium-mediated signaling | neuron differentiation | cellular component organization at cellular level | protein metabolic process | regulation of fibroblast proliferation | regulation of establishment of protein localization | positive regulation of catenin import into nucleus | positive regulation of protein modification process | hair cycle | gland development | regulation of cyclin-dependent protein kinase activity involved in G1/S | tissue morphogenesis | regulation of protein import into nucleus | digestive system development | cellular developmental process | regulation of cellular biosynthetic process | regulation of kinase activity | regulation of intracellular protein kinase cascade | anatomical structure development | mitotic cell cycle | cell surface receptor signaling pathway | signal transducer activity | cell projection organization | metabolic process | transferase activity, transferring phosphorus-containing groups | primary metabolic process | regulation of protein catabolic process | negative regulation of programmed cell death | embryonic organ development | cellular protein localization | phosphotransferase activity, alcohol group as acceptor | nitric-oxide synthase regulator activity | hair cycle process | cell adhesion | regulation of response to DNA damage stimulus | cellular response to stimulus | negative regulation of ERBB signaling pathway | protein kinase activity | neuron projection development | regulation of epidermal growth factor receptor signaling pathway | regulation of hydrolase activity | cellular component morphogenesis | organ development | forebrain development | pallium development | regulation of lipase activity | positive regulation of kinase activity | transferase activity | regulation of phosphate metabolic process | negative regulation of biological process | cell-cell adhesion | positive regulation of intracellular transport | positive regulation of phospholipase activity | regulation of monooxygenase activity | positive regulation of protein transport | anatomical structure formation involved in morphogenesis | negative regulation of protein catabolic process | negative regulation of protein metabolic process | regulation of cell communication | negative regulation of signal transduction | signaling | regulation of oxidoreductase activity | negative regulation of macromolecule metabolic process | cell development | regulation of ERBB signaling pathway | regulation of molecular function | protein localization | regulation of epithelial cell proliferation | cellular component organization or biogenesis at cellular level | positive regulation of phosphorylation | regulation of phospholipase A2 activity | cellular protein metabolic process | enzyme regulator activity | anatomical structure morphogenesis | cellular macromolecule localization | positive regulation of response to stimulus | positive regulation of MAP kinase activity | positive regulation of protein import into nucleus | positive regulation of DNA metabolic process | kinase activity | developmental process | response to external stimulus | localization of cell | cellular protein modification process | positive regulation of cellular process | regulation of transport | single-multicellular organism process | single organism signaling | positive regulation of nitric oxide biosynthetic process | central nervous system development | transmembrane receptor protein tyrosine kinase signaling pathway | in utero embryonic development | positive regulation of metabolic process | ossification | cellular metabolic process | placenta development | regulation of protein localization | exocrine system development | regulation of cell death | positive regulation of cell motility | salivary gland development | negative regulation of cell death | regulation of catenin import into nucleus | chemotaxis | biological adhesion | positive regulation of nucleocytoplasmic transport | positive regulation of signaling | hair follicle development | signal transduction | regulation of signaling | receptor signaling protein tyrosine kinase activity | positive regulation of DNA repair | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

endoplasmic reticulum part | clathrin coat of endocytic vesicle | integral to membrane | intracellular membrane-bounded organelle | plasma membrane part | endosomal part | clathrin-coated endocytic vesicle membrane | coated membrane | endocytic vesicle membrane | clathrin-coated vesicle membrane | organelle membrane | vesicle coat | clathrin-coated vesicle | nuclear membrane | clathrin coat of coated pit | cytoplasmic vesicle | cell | Shc-EGFR complex | intrinsic to membrane | Golgi apparatus part | AP-2 adaptor complex | cytoplasm | clathrin-coated endocytic vesicle | intracellular organelle | endoplasmic reticulum | AP-type membrane coat adaptor complex | endosome membrane | Golgi apparatus | nuclear outer membrane-endoplasmic reticulum membrane network | macromolecular complex | clathrin adaptor complex | endomembrane system | nuclear part | endoplasmic reticulum membrane | plasma membrane | nuclear envelope | organelle part | intracellular organelle part | membrane raft | vesicle | envelope | perinuclear region of cytoplasm | coated pit | organelle envelope | membrane part | cell part | Golgi membrane | endosome | extracellular region | coated vesicle membrane | membrane-bounded organelle | clathrin coat | nucleus | organelle | vesicle membrane | extracellular space | cell periphery | extracellular region part | cytoplasmic part | clathrin vesicle coat | basolateral plasma membrane | cytoplasmic membrane-bounded vesicle | cytoplasmic vesicle part | membrane-bounded vesicle | intracellular part | endocytic vesicle | intracellular | membrane | cytoplasmic vesicle membrane | protein complex | membrane coat | coated vesicle