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QuickView for Digoxin (compound)


PubChem
Name: Digoxin
PubChem Compound ID: 2724385
Description: A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666)
Molecular formula: C41H64O14
Molecular weight: 780.938 g/mol
Synonyms:
MLS000069819; SMR000059217; NCGC00090797-01; Digoxin; 20830-75-5; SPBio_002393; Prestwick_170; Prestwick0_000437; Prestwick1_000437
DrugBank
Identification
Name: Digoxin
Name (isomeric): DB00390
Drug Type: small molecule
Description: A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666)
Synonyms:
Digitalis Glycoside
Brand: Neodioxanin, Digoxin Pediatric, Eudigox, Cogoxin, Rougoxin, Dixina, Stillacor, Dilanacin, Dynamos, Dokim, Longdigox, Lanacrist, Davoxin, Cardoxin, Cordioxil, Lanacordin, Homolle's Digitalin, Neo-Lanicor, Digitekt, Lanoxin, Lanicor, Lenoxin, Lanoxicaps, Vanoxin, Digacin, Lenoxicaps, SK-Digoxin
Category: Cardiotonic Agents, Antiarrhythmic Agents, Enzyme Inhibitors, Anti-Arrhythmia Agents
CAS number: 20830-75-5
Pharmacology
Indication: For the treatment and management of congestive cardiac insufficiency, arrhythmias and heart failure.
Pharmacology: Digoxin, a cardiac glycoside similar to digitoxin, is used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation.
Mechanism of Action:
Digoxin inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium. The sodium calcium exchanger (NCX)in turn tries to extrude the sodium and in so doing, pumps in more calcium. Increased intracellular concentrations of calcium may promote activation of contractile proteins (e.g., actin, myosin). Digoxin also acts on t...
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Absorption: Absorption of digoxin from the elixir pediatric formulation has been demonstrated to be 70% to 85% complete (90% to 100% from the capsules, and 60% to 80% for tablets).
Protein binding: 25%
Biotransformation: Hepatic (but not dependent upon the cytochrome P-450 system). The end metabolites, which include 3 b-digoxigenin, 3-keto-digoxigenin, and their glucuronide and sulfate conjugates, are polar in nature and are postulated to be formed via hydrolysis, oxidation, and conjugation.
Route of elimination: Following intravenous administration to healthy volunteers, 50% to 70% of a digoxin dose is excreted unchanged in the urine.
Half Life: 3.5 to 5 days
Toxicity: Toxicity includes ventricular tachycardia or ventricular fibrillation, or progressive bradyarrhythmias, or heart block. LD50 = 7.8 mg/kg (orally in mice).
Affected organisms: Humans and other mammals
Interactions
Food interaction:
Avoid avocado.
Limit garlic, ginger, gingko, and horse chestnut.
Avoid milk, calcium containing dairy products, iron, antacids, or aluminum salts 2 hours before or 6 hours after using antacids while on this medication.
Avoid salt substitutes containing potassium.
Avoid bran and high fiber foods within 2 hours of taking this medication.
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Drug interaction:
DextrothyroxineThe thyroid hormone, dextrothyroxine, decreases the effect of digoxin.
GatifloxacinGatifloxacin increases the effect of digoxin
HydrochlorothiazidePossible electrolyte variations and arrhythmias
VerapamilVerapamil may increase the serum concentration of Digoxin by decreasing its metabolism and clearance. Monitor for changes in the therapeutic/adverse effects of Digoxin if Verpamail is initiated, discontinued or dose changed.
ColestipolThe resin decreases the effect of digoxin
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