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QuickView for Dicloxacillin (compound)

Name: Dicloxacillin
PubChem Compound ID: 1548960
Description: One of the PENICILLINS which is resistant to PENICILLINASE.
Molecular formula: C19H17Cl2N3O5S
Molecular weight: 470.327 g/mol
Name: Dicloxacillin
Name (isomeric): DB00485
Drug Type: small molecule
Description: One of the PENICILLINS which is resistant to PENICILLINASE.
Dicloxacillinum [INN-Latin]; Diclossacillina [DCIT]; Dicloxacillin Sodium; Dicloxacilline [INN-French]; Dicloxacilin; Dicloxacilina [INN-Spanish]; Dicloxacycline
Brand: Pathocil, Dycill, Maclicine, Dynapen
Category: Anti-Bacterial Agents, Penicillins
CAS number: 3116-76-5
Indication: Used to treat infections caused by penicillinase-producing staphylococci which have demonstrated susceptibility to the drug.
Dicloxacillin is a beta-lactamase resistant penicillin similar to oxacillin. Dicloxacillin has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of dicloxacillin results from the inhibition of cell wall synthesis and is mediated through dicloxacillin binding to penicillin bind...
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Mechanism of Action:
Dicloxacillin exerts a bactericidal action against penicillin-susceptible microorganisms during the state of active multiplication. All penicillins inhibit the biosynthesis of the bacterial cell wall. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, dicloxacillin inhibits the third and last stage of ...
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Absorption: Absorption of the isoxazolyl penicillins after oral administration is rapid but incomplete: peak blood levels are achieved in 1-1.5 hours. Oral absorption of cloxacillin, dicloxacillin, oxacillin and nafcillin is delayed when the drugs are administered after meals.
Protein binding: Binds to serum protein, mainly albumin.
Route of elimination: Dicloxacillin sodium is rapidly excreted as unchanged drug in the urine by glomerular filtration and active tubular secretion.
Half Life: The elimination half-life for dicloxacillin is about 0.7 hour.
Toxicity: Oral LD50 in rat is 3579 mg/kg. Symptoms of overexposure include irritation, rash, labored breathing, hives, itching, wheezing, nausea, chills, and fever.
Affected organisms: Enteric bacteria and other eubacteria
Food interaction:
Take on an empty stomach, food decreases the availability.
Drug interaction:
WarfarinDicloxacillin may decrease the anticoagulant effect of warfarin.
Ethinyl EstradiolThis anti-infectious agent could decrease the effect of the oral contraceptive
MinocyclinePossible antagonism of action
MethotrexateThe penicillin increases the effect and toxicity of methotrexate
AnisindioneDicloxacillin may decrease the anticoagulant effect of anisindione.
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