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QuickView for DRD2 (gene)


Gene Symbol:
DRD2 Homo sapiens Homo sapiens
Full name:
dopamine receptor D2
Synonyms:
D2DR, D2R, D(2) dopamine receptor, dopamine D2 receptor, dopamine receptor D2, dopamine receptor D2 isoform, seven transmembrane helix receptor
Genomic Location:
Chr 11: 112785527-112851091
Description:
This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third ...
Orthologs:
Mus musculus Rattus norvegicus C. elegans Macaca mulatta Bos taurus Danio rerio Canis lupus familiaris Gallus gallus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 11
11q23


Transcripts Names
NM_000795
NM_016574
Protein Names
Q9NZR3
Q9UPA9
P14416



GO Molecular Function

neurotransmitter receptor activity | catecholamine binding | channel regulator activity | cation binding | transmembrane signaling receptor activity | G-protein coupled receptor activity | dopamine binding | receptor binding | binding | signaling receptor activity | potassium channel regulator activity | ion binding | receptor activity | molecular transducer activity | protein binding | signal transducer activity | dopamine receptor activity | drug binding | dopamine receptor activity, coupled via Gi/Go | glutamate receptor binding | ionotropic glutamate receptor binding

GO Biological Process

negative regulation of G-protein coupled receptor protein signaling pathway | regulation of ERK1 and ERK2 cascade | brain development | long-chain fatty acid transport | response to radiation | cell morphogenesis | regulation of biological process | negative regulation of multicellular organismal process | positive regulation of macromolecule biosynthetic process | regulation of dephosphorylation | branching morphogenesis of a nerve | negative regulation of reproductive process | regulation of transmission of nerve impulse | long-term memory | positive regulation of cellular component organization | cell motility | regulation of neurogenesis | neuron projection morphogenesis | regulation of cellular localization | negative regulation of peptide secretion | intracellular signal transduction | regulation of cell development | cytosolic calcium ion transport | regulation of localization | catechol-containing compound metabolic process | response to isoquinoline alkaloid | regulation of biosynthetic process | positive regulation of cell communication | lipid transport | regulation of sodium ion transport | neurotransmitter receptor activity | auditory behavior | phosphatidylinositol metabolic process | establishment of localization | regulation of biological quality | negative regulation of cellular process | positive regulation of developmental process | negative regulation of response to external stimulus | regulation of phosphatase activity | response to metal ion | cell differentiation | cellular macromolecule metabolic process | nervous system development | response to drug | cellular chemical homeostasis | cell part morphogenesis | neurogenesis | positive regulation of phosphate metabolic process | regulation of protein modification process | negative regulation of protein secretion | prepulse inhibition | regulation of peptide hormone secretion | regulation of renal sodium excretion | generation of neurons | phospholipid metabolic process | phenol-containing compound metabolic process | multicellular organismal signaling | regulation of circadian sleep/wake cycle | regulation of response to stimulus | positive regulation of cellular biosynthetic process | cellular process | secretion | response to tropane | regulation of catecholamine secretion | response to morphine | monocarboxylic acid transport | circadian regulation of gene expression | regulation of cell motility | localization | cellular homeostasis | cell projection morphogenesis | regulation of growth hormone secretion | forebrain cell migration | negative regulation of signaling | metal ion transport | visual learning | synaptic transmission | cerebral cortex GABAergic interneuron differentiation | neuron development | regulation of neuronal synaptic plasticity | central nervous system neuron differentiation | synapse assembly | cerebral cortex neuron differentiation | learning | positive regulation of protein kinase activity | macromolecule localization | negative regulation of secretion | response to hypoxia | positive regulation of catalytic activity | regulation of multicellular organism growth | positive regulation of nitrogen compound metabolic process | negative regulation of cell migration | transmembrane signaling receptor activity | regulation of nucleobase-containing compound metabolic process | diencephalon development | negative regulation of hormone secretion | response to inorganic substance | negative regulation of cellular metabolic process | regulation of behavior | regulation of neurological system process | negative regulation of dopamine receptor signaling pathway | regulation of cell differentiation | regulation of system process | regulation of lyase activity | negative regulation of cell motility | regulation of protein kinase B signaling cascade | regulation of cellular process | cellular component organization or biogenesis | regulation of metabolic process | pituitary gland development | G-protein coupled receptor internalization | cytosolic calcium ion homeostasis | neurological system process involved in regulation of systemic arterial blood pressure | positive regulation of cellular protein metabolic process | positive regulation of renal sodium excretion | cellular aromatic compound metabolic process | smooth muscle contraction | icosanoid secretion | regulation of urine volume | cellular component organization | negative regulation of nucleotide metabolic process | cellular lipid metabolic process | calcium ion homeostasis | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway | G-protein coupled receptor activity | calcium ion transport into cytosol | regulation of peptide secretion | muscle contraction | associative learning | circadian sleep/wake cycle process | negative regulation of purine nucleotide biosynthetic process | negative regulation of lyase activity | response to stimulus | negative regulation of cell communication | negative regulation of protein transport | cell morphogenesis involved in neuron differentiation | acid secretion | response to chemical stimulus | negative regulation of cAMP biosynthetic process | transport | regulation of insulin secretion | regulation of excretion | positive regulation of protein metabolic process | response to cocaine | negative regulation of neurological system process | response to stress | regulation of macromolecule biosynthetic process | negative regulation of circadian rhythm | regulation of receptor internalization | substrate-independent telencephalic tangential migration | regulation of cell proliferation | regulation of nucleotide biosynthetic process | positive regulation of nucleobase-containing compound metabolic process | regulation of response to external stimulus | multicellular organismal homeostasis | positive regulation of neuroblast proliferation | circadian rhythm | telencephalon cell migration | peristalsis | regulation of heart rate | reproduction | divalent metal ion transport | response to alcohol | regulation of metal ion transport | regulation of neurotransmitter uptake | rhythmic process | adaptation of signaling pathway | positive regulation of hormone secretion | negative regulation of transport | regulation of protein transport | blood circulation | G-protein coupled receptor signaling pathway | response to endogenous stimulus | negative regulation of metabolic process | cellular component assembly | regulation of cAMP metabolic process | regulation of peptide transport | regulation of synaptic transmission | response to decreased oxygen levels | circadian sleep/wake cycle | positive regulation of multicellular organism growth | response to iron ion | negative regulation of purine nucleotide metabolic process | adenohypophysis development | cell-cell signaling | synaptic transmission, dopaminergic | dopamine metabolic process | activation of protein kinase activity | metal ion homeostasis | negative regulation of blood pressure | response to ethanol | positive regulation of peptide secretion | locomotion | regulation of long-term neuronal synaptic plasticity | central nervous system neuron development | response to light stimulus | response to nicotine | system development | response to oxygen levels | reproductive process | regulation of signal transduction | positive regulation of urine volume | Wnt receptor signaling pathway | multicellular organismal development | negative regulation of catalytic activity | cell migration | regulation of synaptic transmission, GABAergic | regulation of synaptic transmission, glutamatergic | positive regulation of RNA metabolic process | regulation of MAPK cascade | learning or memory | adenylate cyclase-modulating G-protein coupled receptor signaling pathway | positive regulation of multicellular organismal process | intracellular protein kinase cascade | regulation of catalytic activity | lipid metabolic process | regulation of phosphorylation | regulation of hormone secretion | arachidonic acid secretion | telencephalon development | regulation of receptor-mediated endocytosis | cerebral cortex GABAergic interneuron development | response to abiotic stimulus | positive regulation of receptor-mediated endocytosis | regulation of gene expression | fatty acid transport | cellular component biogenesis | positive regulation of secretion | rhythmic behavior | organic substance transport | neurological system process | positive regulation of neurotransmitter transport | regulation of blood pressure | adult walking behavior | diol metabolic process | organophosphate metabolic process | regulation of systemic arterial blood pressure | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of multicellular organismal development | cellular ion homeostasis | response to axon injury | adult locomotory behavior | regulation of macromolecule metabolic process | regulation of dopamine receptor signaling pathway | regulation of dopamine uptake involved in synaptic transmission | behavioral response to ethanol | regulation of transferase activity | elevation of cytosolic calcium ion concentration | signaling receptor activity | regulation of nitrogen compound metabolic process | single-organism process | regulation of cyclic nucleotide biosynthetic process | regulation of cell migration | small molecule metabolic process | negative regulation of nitrogen compound metabolic process | positive regulation of intracellular protein kinase cascade | single-organism reproductive behavior | vesicle-mediated transport | regulation of cellular component movement | regulation of transcription from RNA polymerase II promoter | pigmentation | organic acid transport | synapse organization | axonogenesis | regulation of synaptic transmission, dopaminergic | behavioral response to cocaine | positive regulation of cell differentiation | cerebral cortex GABAergic interneuron migration | cognition | negative regulation of nucleotide biosynthetic process | biological regulation | negative regulation of protein kinase B signaling cascade | locomotory behavior | regulation of primary metabolic process | negative regulation of sequestering of calcium ion | negative regulation of cyclic nucleotide biosynthetic process | cellular component movement | regulation of cellular protein metabolic process | negative regulation of peptide hormone secretion | regulation of amine transport | negative regulation of adenylate cyclase activity | startle response | positive regulation of macromolecule metabolic process | response to toxin | regulation of cyclase activity | regulation of circadian sleep/wake cycle, sleep | regulation of heart contraction | negative regulation of cAMP metabolic process | endocrine system development | cell morphogenesis involved in differentiation | cation homeostasis | positive regulation of biological process | negative regulation of synaptic transmission, glutamatergic | regulation of purine nucleotide metabolic process | regulation of cellular macromolecule biosynthetic process | negative regulation of response to stimulus | dopamine receptor signaling pathway | positive regulation of phosphorus metabolic process | negative regulation of nucleobase-containing compound metabolic process | regulation of nucleotide metabolic process | cellular cation homeostasis | cell communication | positive regulation of transferase activity | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of cAMP biosynthetic process | receptor internalization | positive regulation of catecholamine uptake involved in synaptic transmission | regulation of catecholamine uptake involved in synaptic transmission | regulation of protein metabolic process | system process | positive regulation of signal transduction | positive regulation of biosynthetic process | substrate-independent telencephalic tangential interneuron migration | cellular calcium ion homeostasis | homeostatic process | positive regulation of cell proliferation | regulation of protein phosphorylation | phospholipase C-activating dopamine receptor signaling pathway | regulation of locomotion | glycerolipid metabolic process | regulation of RNA metabolic process | positive regulation of transport | regulation of purine nucleotide biosynthetic process | positive regulation of peptide hormone secretion | response to histamine | regulation of dopamine secretion | negative adaptation of signaling pathway | regulation of potassium ion transport | positive regulation of molecular function | release of sequestered calcium ion into cytosol | neuron differentiation | cellular component organization at cellular level | regulation of establishment of protein localization | positive regulation of protein modification process | regulation of growth | response to organic substance | gland development | negative regulation of behavior | visual behavior | cellular developmental process | regulation of cellular biosynthetic process | catecholamine metabolic process | regulation of ion homeostasis | regulation of kinase activity | response to wounding | response to mechanical stimulus | regulation of intracellular protein kinase cascade | negative regulation of intracellular protein kinase cascade | anatomical structure development | elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway | regulation of multicellular organismal process | response to amine stimulus | cell surface receptor signaling pathway | positive regulation of neurogenesis | reproductive behavior | regulation of neural precursor cell proliferation | signal transducer activity | cell projection organization | metabolic process | lipid localization | positive regulation of cell development | primary metabolic process | dopamine receptor activity | regulation of homeostatic process | regulation of RNA biosynthetic process | circulatory system process | regulation of body fluid levels | regulation of vesicle-mediated transport | chemical homeostasis | calcium ion transport | endocytosis | regulation of secretion | behavior | icosanoid transport | cellular response to stimulus | single organism reproductive process | neuron projection development | organic substance metabolic process | regulation of sequestering of calcium ion | regulation of hydrolase activity | cellular component morphogenesis | positive regulation of neurotransmitter uptake | grooming behavior | neuron-neuron synaptic transmission | negative regulation of biosynthetic process | organ development | forebrain development | negative regulation of cellular component movement | regulation of protein secretion | positive regulation of G-protein coupled receptor protein signaling pathway | positive regulation of ERK1 and ERK2 cascade | desensitization of G-protein coupled receptor protein signaling pathway | positive regulation of kinase activity | negative regulation of circadian sleep/wake cycle, sleep | ion homeostasis | regulation of phosphate metabolic process | response to alkaloid | negative regulation of biological process | phospholipase C-activating G-protein coupled receptor signaling pathway | renal system process | negative regulation of transmission of nerve impulse | positive regulation of MAPK cascade | temperature homeostasis | regulation of adenylate cyclase activity | anatomical structure formation involved in morphogenesis | memory | adult behavior | sensory perception | interneuron migration from the subpallium to the cortex | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | adenylate cyclase-inhibiting dopamine receptor signaling pathway | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | negative regulation of insulin secretion | signaling | feeding behavior | positive regulation of growth | regulation of transcription, DNA-dependent | response to organic cyclic compound | negative regulation of cyclase activity | neuromuscular process | cell development | regulation of endocytosis | single-organism behavior | sensory perception of chemical stimulus | regulation of molecular function | protein localization | cellular component organization or biogenesis at cellular level | positive regulation of phosphorylation | carboxylic acid transport | morphogenesis of a branching structure | anatomical structure morphogenesis | cation transport | positive regulation of response to stimulus | cellular divalent inorganic cation homeostasis | mechanosensory behavior | positive regulation of receptor internalization | regulation of circadian rhythm | regulation of nervous system development | reduction of cytosolic calcium ion concentration | regulation of developmental process | regulation of ion transport | receptor-mediated endocytosis | glycerophospholipid metabolic process | regulation of G-protein coupled receptor protein signaling pathway | positive regulation of neural precursor cell proliferation | regulation of reproductive process | regulation of phosphoprotein phosphatase activity | developmental process | response to external stimulus | localization of cell | regulation of cyclic nucleotide metabolic process | negative regulation of cellular biosynthetic process | positive regulation of amine transport | positive regulation of cellular process | regulation of transport | positive regulation of transcription, DNA-dependent | positive regulation of dopamine uptake involved in synaptic transmission | negative regulation of cell proliferation | dopamine receptor activity, coupled via Gi/Go | circadian behavior | receptor metabolic process | response to organic nitrogen | cellular metal ion homeostasis | single-multicellular organism process | single organism signaling | positive regulation of transcription from RNA polymerase II promoter | divalent inorganic cation transport | negative regulation of cyclic nucleotide metabolic process | transmission of nerve impulse | negative regulation of synaptic transmission | central nervous system development | regulation of neurotransmitter transport | positive regulation of metabolic process | regulation of synaptic plasticity | response to amphetamine | cellular component assembly at cellular level | ion transport | phasic smooth muscle contraction | cellular metabolic process | regulation of protein localization | sensory perception of smell | positive regulation of growth hormone secretion | divalent inorganic cation homeostasis | negative regulation of locomotion | positive regulation of endocytosis | regulation of cellular component organization | muscle system process | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

secretory granule | dendritic spine | integral to membrane | dendrite | intracellular membrane-bounded organelle | synapse | plasma membrane part | neuron projection | clathrin-coated vesicle membrane | organelle membrane | clathrin-coated vesicle | cytoplasmic vesicle | cell body | cell | neuronal cell body | intrinsic to membrane | intracellular non-membrane-bounded organelle | cell projection part | cytoplasm | acrosomal vesicle | intracellular organelle | flagellum | synapse part | cell projection | endomembrane system | neuron spine | plasma membrane | perikaryon | axon part | organelle part | intracellular organelle part | dendritic spine head | vesicle | postsynaptic density | membrane part | integral to plasma membrane | synaptic vesicle | cell part | coated vesicle membrane | membrane-bounded organelle | organelle | vesicle membrane | axon terminus | cell periphery | cytoplasmic part | axon | cytoplasmic membrane-bounded vesicle | cytoplasmic vesicle part | neuron projection terminus | synaptic vesicle membrane | membrane-bounded vesicle | non-membrane-bounded organelle | cytoskeleton | intracellular part | endocytic vesicle | intracellular | lateral plasma membrane | membrane | cytoskeletal part | cytoplasmic vesicle membrane | intrinsic to plasma membrane | coated vesicle